goiter Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A thyroid gland disease that involves an abnormal enlargement of the thyroid gland. (Human Disease Ontology, DOID_12176)
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Genes

285 genes co-occuring with the disease goiter in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TG thyroglobulin 2.94864
TRH thyrotropin-releasing hormone 2.29774
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.26744
TPO thyroid peroxidase 2.25478
TSHR thyroid stimulating hormone receptor 2.0581
THRB thyroid hormone receptor, beta 1.76864
TXNRD2 thioredoxin reductase 2 1.73687
CALCA calcitonin-related polypeptide alpha 1.68453
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.51062
PTH parathyroid hormone 1.46891
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 1.33807
LGALS3 lectin, galactoside-binding, soluble, 3 1.33109
TSHB thyroid stimulating hormone, beta 1.17121
IYD iodotyrosine deiodinase 1.1588
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.10931
DUOX2 dual oxidase 2 1.08076
IGF1 insulin-like growth factor 1 (somatomedin C) 1.0753
RET ret proto-oncogene 1.07194
DUOXA2 dual oxidase maturation factor 2 0.986428
PRL prolactin 0.944521
BGLAP bone gamma-carboxyglutamate (gla) protein 0.870415
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 0.817565
PAX8 paired box 8 0.815924
ALPP alkaline phosphatase, placental 0.784755
NKX2-1 NK2 homeobox 1 0.778204
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.778204
ALPPL2 alkaline phosphatase, placental-like 2 0.770844
ALPL alkaline phosphatase, liver/bone/kidney 0.769618
SERINC5 serine incorporator 5 0.766351
SHBG sex hormone-binding globulin 0.764718
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.743547
KRT19 keratin 19, type I 0.695103
SST somatostatin 0.684692
DICER1 dicer 1, ribonuclease type III 0.671527
GJB2 gap junction protein, beta 2, 26kDa 0.653276
ICAM1 intercellular adhesion molecule 1 0.622575
DYNLT1 dynein, light chain, Tctex-type 1 0.615529
RNH1 ribonuclease/angiogenin inhibitor 1 0.612792
PTEN phosphatase and tensin homolog 0.606543
LYPD1 LY6/PLAUR domain containing 1 0.605762
CCDC6 coiled-coil domain containing 6 0.59991
RGS12 regulator of G-protein signaling 12 0.59874
QPCTL glutaminyl-peptide cyclotransferase-like 0.59874
FASLG Fas ligand (TNF superfamily, member 6) 0.595623
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.594843
ZCCHC12 zinc finger, CCHC domain containing 12 0.58433
PAAF1 proteasomal ATPase-associated factor 1 0.579272
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.57305
PCNA proliferating cell nuclear antigen 0.56722
DIO2 deiodinase, iodothyronine, type II 0.565277
IL1B interleukin 1, beta 0.551686
LPO lactoperoxidase 0.543542
ALB albumin 0.514571
RHPN2 rhophilin, Rho GTPase binding protein 2 0.502675
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.502675
LRP2 low density lipoprotein receptor-related protein 2 0.499997
IL6 interleukin 6 0.495793
TGFB1 transforming growth factor, beta 1 0.489311
CERS5 ceramide synthase 5 0.485505
DUOXA1 dual oxidase maturation factor 1 0.475255
GPX1 glutathione peroxidase 1 0.474119
BMP8A bone morphogenetic protein 8a 0.471468
GPX5 glutathione peroxidase 5 0.454093
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 0.452962
GPX4 glutathione peroxidase 4 0.451078
CLIC6 chloride intracellular channel 6 0.450701
GNAS GNAS complex locus 0.449947
TTR transthyretin 0.448441
IRX5 iroquois homeobox 5 0.445052
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.4443
UNG uracil-DNA glycosylase 0.443547
CD4 CD4 molecule 0.443547
HLA-C major histocompatibility complex, class I, C 0.435651
SNAI3 snail family zinc finger 3 0.431894
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.42739
ABR active BCR-related 0.42139
LIN52 lin-52 DREAM MuvB core complex component 0.419142
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.41727
ADCY2 adenylate cyclase 2 (brain) 0.415773
TDG thymine-DNA glycosylase 0.415398
IRX4 iroquois homeobox 4 0.410161
THRA thyroid hormone receptor, alpha 0.403811
PICALM phosphatidylinositol binding clathrin assembly protein 0.393374
INS insulin 0.392257
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.389281
EFTUD1 elongation factor Tu GTP binding domain containing 1 0.385565
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 0.382966
GMPS guanine monphosphate synthase 0.381852
AUH AU RNA binding protein/enoyl-CoA hydratase 0.38111
LRRN1 leucine rich repeat neuronal 1 0.374809
THEM5 thioesterase superfamily member 5 0.374809
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.370368
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.364824
IL1A interleukin 1, alpha 0.362978
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.360395
C8ORF4 chromosome 8 open reading frame 4 0.359657
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.357077
LGALS1 lectin, galactoside-binding, soluble, 1 0.356341
POMC proopiomelanocortin 0.352291
VILL villin-like 0.342372
ABHD16A abhydrolase domain containing 16A 0.337975
B3GAT1 beta-1,3-glucuronyltransferase 1 0.335046
CYS1 cystin 1 0.332487
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 0.332121
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.327375
DUOX1 dual oxidase 1 0.32373
TNS1 tensin 1 0.322637
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.321545
HBA2 hemoglobin, alpha 2 0.318635
GPR39 G protein-coupled receptor 39 0.316819
ADAT2 adenosine deaminase, tRNA-specific 2 0.312464
GCOM1 GRINL1A complex locus 1 0.311739
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 0.307033
RLN2 relaxin 2 0.305587
FOS FBJ murine osteosarcoma viral oncogene homolog 0.304864
CXCL10 chemokine (C-X-C motif) ligand 10 0.304503
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.300533
VEGFA vascular endothelial growth factor A 0.298731
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.298371
MEN1 multiple endocrine neoplasia I 0.297291
KALRN kalirin, RhoGEF kinase 0.292975
CPSF3L cleavage and polyadenylation specific factor 3-like 0.291898
IL2 interleukin 2 0.289744
GHRL ghrelin/obestatin prepropeptide 0.287593
IRX1 iroquois homeobox 1 0.287235
CP ceruloplasmin (ferroxidase) 0.286519
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.286519
PRSS3 protease, serine, 3 0.286519
HRAS Harvey rat sarcoma viral oncogene homolog 0.278654
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.277227
F8 coagulation factor VIII, procoagulant component 0.276514
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.274376
PRAMEF12 PRAME family member 12 0.271174
TF transferrin 0.264785
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.264431
FLNB filamin B, beta 0.261599
SNN stannin 0.25983
CD79A CD79a molecule, immunoglobulin-associated alpha 0.256652
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.256299
FOXI1 forkhead box I1 0.254888
SERP1 stress-associated endoplasmic reticulum protein 1 0.252774
SOD2 superoxide dismutase 2, mitochondrial 0.252422
TSPAN1 tetraspanin 1 0.24996
SAV1 salvador family WW domain containing protein 1 0.244345
CCND1 cyclin D1 0.243645
LYZ lysozyme 0.242945
INSL3 insulin-like 3 (Leydig cell) 0.240847
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.235268
CD40 CD40 molecule, TNF receptor superfamily member 5 0.235268
PMF1 polyamine-modulated factor 1 0.23353
GNPDA1 glucosamine-6-phosphate deaminase 1 0.231795
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.231448
NCAM1 neural cell adhesion molecule 1 0.227297
OPTC opticin 0.225229
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.224884
CD84 CD84 molecule 0.213621
ESR1 estrogen receptor 1 0.208579
RAB2A RAB2A, member RAS oncogene family 0.207578
IGFBP3 insulin-like growth factor binding protein 3 0.202946
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.201635
C7ORF49 chromosome 7 open reading frame 49 0.197099
CD226 CD226 molecule 0.193915
CD34 CD34 molecule 0.190786
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.189551
FBN2 fibrillin 2 0.188326
MIR222 microRNA 222 0.187719
CTSB cathepsin B 0.186811
PRDX2 peroxiredoxin 2 0.18621
SLC30A2 solute carrier family 30 (zinc transporter), member 2 0.185016
SECISBP2 SECIS binding protein 2 0.18472
RNASEH2A ribonuclease H2, subunit A 0.180937
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.180652
MMP23B matrix metallopeptidase 23B 0.178403
RXRB retinoid X receptor, beta 0.176485
CD19 CD19 molecule 0.175411
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.172291
KRT20 keratin 20, type I 0.169812
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.168617
SRRM2 serine/arginine repetitive matrix 2 0.167682
TP53 tumor protein p53 0.166995
GHRH growth hormone releasing hormone 0.166544
PROK1 prokineticin 1 0.165874
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.165217
FGFR1 fibroblast growth factor receptor 1 0.165001
GAGE1 G antigen 1 0.164359
IFNA1 interferon, alpha 1 0.164359
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.164359
ERP29 endoplasmic reticulum protein 29 0.163317
GHSR growth hormone secretagogue receptor 0.163111
CAT catalase 0.160387
TRIM37 tripartite motif containing 37 0.15948
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.141457
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.133958
RAB3D RAB3D, member RAS oncogene family 0.133669
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.133412
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.133329
LNPEP leucyl/cystinyl aminopeptidase 0.133138
NLRP12 NLR family, pyrin domain containing 12 0.133084
SIX4 SIX homeobox 4 0.13183
PGD phosphogluconate dehydrogenase 0.131781
FRS2 fibroblast growth factor receptor substrate 2 0.131173
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 0.129724
NOTCH1 notch 1 0.129513
GAGE12I G antigen 12I 0.129129
SPAG7 sperm associated antigen 7 0.129082
MCM3 minichromosome maintenance complex component 3 0.12894
ASPH aspartate beta-hydroxylase 0.128715
PCSK2 proprotein convertase subtilisin/kexin type 2 0.128537
TRIB1 tribbles pseudokinase 1 0.128537
LGALS7B lectin, galactoside-binding, soluble, 7B 0.128086
PDGFA platelet-derived growth factor alpha polypeptide 0.127966
HAT1 histone acetyltransferase 1 0.127547
TMEM127 transmembrane protein 127 0.127351
NGDN neuroguidin, EIF4E binding protein 0.126726
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.126688
HECA headcase homolog (Drosophila) 0.126011
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.125529
UST uronyl-2-sulfotransferase 0.125467
GP2 glycoprotein 2 (zymogen granule membrane) 0.124297
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.124163
CD3D CD3d molecule, delta (CD3-TCR complex) 0.123666
MGAM maltase-glucoamylase 0.12341
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.123106
TOX thymocyte selection-associated high mobility group box 0.122817
RXRA retinoid X receptor, alpha 0.122793
CRABP1 cellular retinoic acid binding protein 1 0.122624
HES2 hes family bHLH transcription factor 2 0.122228
COL3A1 collagen, type III, alpha 1 0.121389
PRDM16 PR domain containing 16 0.121363
OSCAR osteoclast associated, immunoglobulin-like receptor 0.121098
TSPY3 testis specific protein, Y-linked 3 0.120832
TSPY10 testis specific protein, Y-linked 10 0.120832
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.120453
ANKRD11 ankyrin repeat domain 11 0.119332
IL16 interleukin 16 0.119039
PROK2 prokineticin 2 0.119039
MRAP melanocortin 2 receptor accessory protein 0.118206
CLEC4C C-type lectin domain family 4, member C 0.117963
CD276 CD276 molecule 0.117716
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.117685
CCL13 chemokine (C-C motif) ligand 13 0.117372
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.117122
CXCL14 chemokine (C-X-C motif) ligand 14 0.117058
CFD complement factor D (adipsin) 0.116929
CHGA chromogranin A 0.116606
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.116149
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.116116
MMP11 matrix metallopeptidase 11 0.114692
CYB5A cytochrome b5 type A (microsomal) 0.114692
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.11441
UROD uroporphyrinogen decarboxylase 0.113661
HNMT histamine N-methyltransferase 0.113333
RPSA ribosomal protein SA 0.113004
VCAM1 vascular cell adhesion molecule 1 0.112743
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.112706
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.112668
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.111448
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.110981
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.110423
NID1 nidogen 1 0.10994
VEGFC vascular endothelial growth factor C 0.109325
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.108783
CASQ2 calsequestrin 2 (cardiac muscle) 0.108614
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.108192
CD58 CD58 molecule 0.108066
PTMS parathymosin 0.107589
MCM8 minichromosome maintenance complex component 8 0.107372
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.107112
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.106581
OAT ornithine aminotransferase 0.106403
AMELY amelogenin, Y-linked 0.106269
IL22 interleukin 22 0.106136
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.105868
PHB prohibitin 0.105273
TPT1 tumor protein, translationally-controlled 1 0.105228
CLEC3A C-type lectin domain family 3, member A 0.105091
CLEC2B C-type lectin domain family 2, member B 0.104489
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.104395
LAMA2 laminin, alpha 2 0.103356
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.10326
GAS6 growth arrest-specific 6 0.10302
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.102492
AMELX amelogenin, X-linked 0.102393
MIR221 microRNA 221 0.102344
NDRG1 N-myc downstream regulated 1 0.10195