glycopyrronium bromide-4709 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the glycopyrronium bromide-4709 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT11 acyl-CoA thioesterase 11
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
ANKFY1 ankyrin repeat and FYVE domain containing 1
AQP3 aquaporin 3 (Gill blood group)
ASPH aspartate beta-hydroxylase
ATXN2L ataxin 2-like
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBX2 chromobox homolog 2
CCDC40 coiled-coil domain containing 40
CD22 CD22 molecule
CEP162 centrosomal protein 162kDa
CEP164 centrosomal protein 164kDa
CLEC4A C-type lectin domain family 4, member A
CPQ carboxypeptidase Q
CRMP1 collapsin response mediator protein 1
CTSZ cathepsin Z
DGKE diacylglycerol kinase, epsilon 64kDa
DMXL2 Dmx-like 2
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUSP1 dual specificity phosphatase 1
EFCAB11 EF-hand calcium binding domain 11
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ERO1LB ERO1-like beta (S. cerevisiae)
ETV6 ets variant 6
FBLN1 fibulin 1
FGFR1 fibroblast growth factor receptor 1
FRMD1 FERM domain containing 1
FST follistatin
GID4 GID complex subunit 4
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPATCH4 G patch domain containing 4
GRB10 growth factor receptor-bound protein 10
GRIP2 glutamate receptor interacting protein 2
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIST1H2BC histone cluster 1, H2bc
HNRNPM heterogeneous nuclear ribonucleoprotein M
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IDUA iduronidase, alpha-L-
IRS4 insulin receptor substrate 4
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KIAA1024 KIAA1024
LAMA2 laminin, alpha 2
LAMC2 laminin, gamma 2
LARP7 La ribonucleoprotein domain family, member 7
LIG3 ligase III, DNA, ATP-dependent
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOXL2 lysyl oxidase-like 2
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPK14 mitogen-activated protein kinase 14
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MNDA myeloid cell nuclear differentiation antigen
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYO15A myosin XVA
NME5 NME/NM23 family member 5
NNMT nicotinamide N-methyltransferase
OSMR oncostatin M receptor
PCDHA6 protocadherin alpha 6
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PGAM2 phosphoglycerate mutase 2 (muscle)
PHTF2 putative homeodomain transcription factor 2
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCE protein kinase C, epsilon
PTCRA pre T-cell antigen receptor alpha
PXN paxillin
RAB6A RAB6A, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNGTT RNA guanylyltransferase and 5'-phosphatase
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SAP30 Sin3A-associated protein, 30kDa
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIM2 single-minded family bHLH transcription factor 2
SIX3 SIX homeobox 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SORT1 sortilin 1
SPRED2 sprouty-related, EVH1 domain containing 2
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
STRN3 striatin, calmodulin binding protein 3
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCF3 transcription factor 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM259 transmembrane protein 259
VCAN versican
XIST X inactive specific transcript (non-protein coding)
ZIC3 Zic family member 3

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADCY6 adenylate cyclase 6
ADRBK2 adrenergic, beta, receptor kinase 2
AIM1 absent in melanoma 1
ARL15 ADP-ribosylation factor-like 15
ASAP1-IT1 ASAP1 intronic transcript 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BHLHE41 basic helix-loop-helix family, member e41
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC69 coiled-coil domain containing 69
CCP110 centriolar coiled coil protein 110kDa
CEL carboxyl ester lipase
CISH cytokine inducible SH2-containing protein
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COL4A5 collagen, type IV, alpha 5
CORO7 coronin 7
CORT cortistatin
CRY2 cryptochrome circadian clock 2
CSTA cystatin A (stefin A)
DCAF13 DDB1 and CUL4 associated factor 13
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGFL7 EGF-like-domain, multiple 7
ENO2 enolase 2 (gamma, neuronal)
ERCC6 excision repair cross-complementation group 6
FAM155A family with sequence similarity 155, member A
FAM63A family with sequence similarity 63, member A
FLJ21369 uncharacterized protein FLJ21369
GLI3 GLI family zinc finger 3
GMPR guanosine monophosphate reductase
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR87 G protein-coupled receptor 87
HIST1H2BN histone cluster 1, H2bn
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOXC8 homeobox C8
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IL12RB1 interleukin 12 receptor, beta 1
IRF1 interferon regulatory factor 1
KDM5C lysine (K)-specific demethylase 5C
KDM7A lysine (K)-specific demethylase 7A
KIAA0895 KIAA0895
KPNA5 karyopherin alpha 5 (importin alpha 6)
KRT13 keratin 13, type I
KRT31 keratin 31, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LHX6 LIM homeobox 6
LRRC20 leucine rich repeat containing 20
LYPLA2P1 lysophospholipase II pseudogene 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MED15 mediator complex subunit 15
MFAP2 microfibrillar-associated protein 2
MRPL52 mitochondrial ribosomal protein L52
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKX3-2 NK3 homeobox 2
NXPH4 neurexophilin 4
PARP12 poly (ADP-ribose) polymerase family, member 12
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PLAT plasminogen activator, tissue
PMCH pro-melanin-concentrating hormone
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRF1 perforin 1 (pore forming protein)
PRSS53 protease, serine, 53
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRE protein tyrosine phosphatase, receptor type, E
RBM41 RNA binding motif protein 41
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RNF39 ring finger protein 39
SCML2 sex comb on midleg-like 2 (Drosophila)
SGMS1 sphingomyelin synthase 1
SIK1 salt-inducible kinase 1
SKI SKI proto-oncogene
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPAG4 sperm associated antigen 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SYT17 synaptotagmin XVII
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMC5 transmembrane channel-like 5
TMEM212 transmembrane protein 212
TMEM254 transmembrane protein 254
TMEM53 transmembrane protein 53
TMPRSS3 transmembrane protease, serine 3
TUBB2B tubulin, beta 2B class IIb
VASH1 vasohibin 1
VGF VGF nerve growth factor inducible
XK X-linked Kx blood group
ZNF10 zinc finger protein 10
ZNF350 zinc finger protein 350