glycocholic acid-2454 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the glycocholic acid-2454 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADCY9 adenylate cyclase 9
AGGF1 angiogenic factor with G patch and FHA domains 1
ANGPTL2 angiopoietin-like 2
ANK1 ankyrin 1, erythrocytic
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
AQP4 aquaporin 4
ARHGAP32 Rho GTPase activating protein 32
ARMCX4 armadillo repeat containing, X-linked 4
BAIAP2 BAI1-associated protein 2
BCAP29 B-cell receptor-associated protein 29
BEGAIN brain-enriched guanylate kinase-associated
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCDC85B coiled-coil domain containing 85B
CCR2 chemokine (C-C motif) receptor 2
CD59 CD59 molecule, complement regulatory protein
CDC14A cell division cycle 14A
CDH10 cadherin 10, type 2 (T2-cadherin)
CFLAR CASP8 and FADD-like apoptosis regulator
COL18A1 collagen, type XVIII, alpha 1
COL4A1 collagen, type IV, alpha 1
CREBZF CREB/ATF bZIP transcription factor
CTRL chymotrypsin-like
CTSE cathepsin E
DEAF1 DEAF1 transcription factor
ECE1 endothelin converting enzyme 1
EIF1 eukaryotic translation initiation factor 1
FAM131A family with sequence similarity 131, member A
FAM182B family with sequence similarity 182, member B
FASLG Fas ligand (TNF superfamily, member 6)
FCMR Fc fragment of IgM receptor
FGF12 fibroblast growth factor 12
GABARAPL1 GABA(A) receptor-associated protein like 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GVINP1 GTPase, very large interferon inducible pseudogene 1
HNRNPM heterogeneous nuclear ribonucleoprotein M
IGFBP4 insulin-like growth factor binding protein 4
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INCENP inner centromere protein antigens 135/155kDa
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDM4B lysine (K)-specific demethylase 4B
LAMB3 laminin, beta 3
MAOA monoamine oxidase A
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
METTL16 methyltransferase like 16
NEBL nebulette
NFYA nuclear transcription factor Y, alpha
NOTCH2 notch 2
NPC1 Niemann-Pick disease, type C1
NRF1 nuclear respiratory factor 1
NUP188 nucleoporin 188kDa
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PARP12 poly (ADP-ribose) polymerase family, member 12
PDE4C phosphodiesterase 4C, cAMP-specific
PDIA2 protein disulfide isomerase family A, member 2
PLA2G3 phospholipase A2, group III
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PNPLA3 patatin-like phospholipase domain containing 3
POU2F2 POU class 2 homeobox 2
PQLC2 PQ loop repeat containing 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RNF6 ring finger protein (C3H2C3 type) 6
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS28 ribosomal protein S28
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SFTPC surfactant protein C
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC17A2 solute carrier family 17, member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SMAD5 SMAD family member 5
SNX13 sorting nexin 13
SOCS1 suppressor of cytokine signaling 1
SPPL2B signal peptide peptidase like 2B
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STS steroid sulfatase (microsomal), isozyme S
SYCP2 synaptonemal complex protein 2
SYT2 synaptotagmin II
SYT5 synaptotagmin V
TBX5 T-box 5
TEC tec protein tyrosine kinase
TEX40 testis expressed 40
TFF2 trefoil factor 2
TMEM140 transmembrane protein 140
TPM3 tropomyosin 3
TRD T cell receptor delta locus
TRIM23 tripartite motif containing 23
UCN urocortin
VAV2 vav 2 guanine nucleotide exchange factor
WHSC1 Wolf-Hirschhorn syndrome candidate 1
ZER1 zyg-11 related, cell cycle regulator
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF235 zinc finger protein 235
ZNF492 zinc finger protein 492
ZNF507 zinc finger protein 507
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ADTRP androgen-dependent TFPI-regulating protein
ANXA2P2 annexin A2 pseudogene 2
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP7B ATPase, Cu++ transporting, beta polypeptide
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTF3P12 basic transcription factor 3 pseudogene 12
C22ORF46 chromosome 22 open reading frame 46
CA11 carbonic anhydrase XI
CBX7 chromobox homolog 7
CD79A CD79a molecule, immunoglobulin-associated alpha
CD82 CD82 molecule
CDK3 cyclin-dependent kinase 3
CDKL3 cyclin-dependent kinase-like 3
CDR2L cerebellar degeneration-related protein 2-like
CENPT centromere protein T
CHML choroideremia-like (Rab escort protein 2)
CLCF1 cardiotrophin-like cytokine factor 1
COL9A2 collagen, type IX, alpha 2
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
DOK3 docking protein 3
EFNA3 ephrin-A3
EPHA4 EPH receptor A4
EXOSC1 exosome component 1
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FGF23 fibroblast growth factor 23
GIPC1 GIPC PDZ domain containing family, member 1
GJA8 gap junction protein, alpha 8, 50kDa
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAMP hepcidin antimicrobial peptide
HDAC7 histone deacetylase 7
HIST1H2AE histone cluster 1, H2ae
HIST1H2AJ histone cluster 1, H2aj
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA5 homeobox A5
HOXC8 homeobox C8
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGSF6 immunoglobulin superfamily, member 6
IL18 interleukin 18
IL24 interleukin 24
INF2 inverted formin, FH2 and WH2 domain containing
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KLHL21 kelch-like family member 21
KLHL28 kelch-like family member 28
LIMD2 LIM domain containing 2
LNPEP leucyl/cystinyl aminopeptidase
LOC257152 uncharacterized LOC257152
LRP3 low density lipoprotein receptor-related protein 3
LY6D lymphocyte antigen 6 complex, locus D
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK10 mitogen-activated protein kinase 10
MRAS muscle RAS oncogene homolog
MRPL52 mitochondrial ribosomal protein L52
MYBPH myosin binding protein H
NCALD neurocalcin delta
NCKAP1L NCK-associated protein 1-like
NINJ2 ninjurin 2
NIPAL2 NIPA-like domain containing 2
NPFFR1 neuropeptide FF receptor 1
NXPH4 neurexophilin 4
OCEL1 occludin/ELL domain containing 1
OLAH oleoyl-ACP hydrolase
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI1 peptidyl arginine deiminase, type I
PADI2 peptidyl arginine deiminase, type II
PDGFD platelet derived growth factor D
PER3 period circadian clock 3
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
QPCTL glutaminyl-peptide cyclotransferase-like
QSER1 glutamine and serine rich 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHOB ras homolog family member B
SMYD5 SMYD family member 5
SPIN1 spindlin 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM180 transmembrane protein 180
TMEM209 transmembrane protein 209
TMOD3 tropomodulin 3 (ubiquitous)
TRAIP TRAF interacting protein
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBTD1 ubiquitin domain containing 1
VEGFC vascular endothelial growth factor C
VNN1 vanin 1
YPEL1 yippee-like 1 (Drosophila)
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF10 zinc finger protein 10
ZNF155 zinc finger protein 155
ZNF493 zinc finger protein 493
ZNF506 zinc finger protein 506
ZNF528 zinc finger protein 528
ZNF552 zinc finger protein 552
ZNF747 zinc finger protein 747