glutathione metabolism Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. (Gene Ontology, GO_0006749)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa00480.html
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Genes

37 proteins participating in the glutathione metabolism pathway from the KEGG Pathways dataset.

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GGT1 gamma-glutamyltransferase 1
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GPX5 glutathione peroxidase 5
GPX6 glutathione peroxidase 6
GPX7 glutathione peroxidase 7
GSR glutathione reductase
GSS glutathione synthetase
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
GSTA4 glutathione S-transferase alpha 4
GSTA5 glutathione S-transferase alpha 5
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GSTZ1 glutathione S-transferase zeta 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
MGST1 microsomal glutathione S-transferase 1
MGST2 microsomal glutathione S-transferase 2
MGST3 microsomal glutathione S-transferase 3
OPLAH 5-oxoprolinase (ATP-hydrolysing)
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum)