glucose intolerance Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

334 genes co-occuring with the disease glucose intolerance in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
INS insulin 3.01927
LEP leptin 1.9638
GCG glucagon 1.94501
INSR insulin receptor 1.83274
IRS1 insulin receptor substrate 1 1.56622
GCK glucokinase (hexokinase 4) 1.50096
GIP gastric inhibitory polypeptide 1.39826
RETN resistin 1.39083
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.36902
NNT nicotinamide nucleotide transhydrogenase 1.36727
IGF1 insulin-like growth factor 1 (somatomedin C) 1.32498
PPARG peroxisome proliferator-activated receptor gamma 1.3193
IRS2 insulin receptor substrate 2 1.30401
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.29615
G6PC glucose-6-phosphatase, catalytic subunit 1.16949
FOXO1 forkhead box O1 1.16606
LEPR leptin receptor 1.14093
NPY neuropeptide Y 1.1367
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.12698
SST somatostatin 1.09461
HMX1 H6 family homeobox 1 1.09377
SREBF1 sterol regulatory element binding transcription factor 1 1.06858
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.05261
APOB apolipoprotein B 1.04167
LIPE lipase, hormone-sensitive 1.03872
FASN fatty acid synthase 1.02144
PPARA peroxisome proliferator-activated receptor alpha 1.02018
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.0071
SH2B1 SH2B adaptor protein 1 0.964567
AGRP agouti related neuropeptide 0.954943
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.942858
CRP C-reactive protein, pentraxin-related 0.927519
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.90321
RBP4 retinol binding protein 4, plasma 0.889668
ACE angiotensin I converting enzyme 0.882292
GLS2 glutaminase 2 (liver, mitochondrial) 0.872462
ALB albumin 0.869187
CHKB choline kinase beta 0.865912
SHBG sex hormone-binding globulin 0.863865
SYT7 synaptotagmin VII 0.863046
ADIPOR1 adiponectin receptor 1 0.858134
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.852811
POMC proopiomelanocortin 0.850764
NAMPT nicotinamide phosphoribosyltransferase 0.843392
DOC2B double C2-like domains, beta 0.836017
PPY pancreatic polypeptide 0.834378
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.826999
GLP1R glucagon-like peptide 1 receptor 0.818385
LPL lipoprotein lipase 0.817565
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.817155
SIDT2 SID1 transmembrane family, member 2 0.816745
CPT1A carnitine palmitoyltransferase 1A (liver) 0.811821
DGAT1 diacylglycerol O-acyltransferase 1 0.811411
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.808129
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.801974
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.800744
GPRC6A G protein-coupled receptor, class C, group 6, member A 0.800333
JUN jun proto-oncogene 0.794181
GIPR gastric inhibitory polypeptide receptor 0.793361
FFAR1 free fatty acid receptor 1 0.771661
TCEAL8 transcription elongation factor A (SII)-like 8 0.762678
HBA2 hemoglobin, alpha 2 0.762271
STX4 syntaxin 4 0.759008
HBA1 hemoglobin, alpha 1 0.751271
GHRL ghrelin/obestatin prepropeptide 0.750457
MOGAT2 monoacylglycerol O-acyltransferase 2 0.74761
IGFBP1 insulin-like growth factor binding protein 1 0.741111
CCL2 chemokine (C-C motif) ligand 2 0.730976
SIRT1 sirtuin 1 0.721673
CMKLR1 chemerin chemokine-like receptor 1 0.72127
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.718443
ADIPOR2 adiponectin receptor 2 0.717232
STXBP3 syntaxin binding protein 3 0.709572
DGAT2 diacylglycerol O-acyltransferase 2 0.703938
IAPP islet amyloid polypeptide 0.695905
XBP1 X-box binding protein 1 0.694702
PRKCE protein kinase C, epsilon 0.691896
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.691495
SOCS3 suppressor of cytokine signaling 3 0.690694
ERN1 endoplasmic reticulum to nucleus signaling 1 0.687091
ZDHHC23 zinc finger, DHHC-type containing 23 0.662784
CD36 CD36 molecule (thrombospondin receptor) 0.656837
COG2 component of oligomeric golgi complex 2 0.65288
HK1 hexokinase 1 0.649323
MOGAT1 monoacylglycerol O-acyltransferase 1 0.642615
CRTC2 CREB regulated transcription coactivator 2 0.635135
ERO1LB ERO1-like beta (S. cerevisiae) 0.633169
CNR1 cannabinoid receptor 1 (brain) 0.631991
FGF21 fibroblast growth factor 21 0.62885
PRG4 proteoglycan 4 0.621008
ACE2 angiotensin I converting enzyme 2 0.61866
DPP4 dipeptidyl-peptidase 4 0.610838
IL6 interleukin 6 0.60186
PNPLA2 patatin-like phospholipase domain containing 2 0.597961
PDX1 pancreatic and duodenal homeobox 1 0.596012
PYCR1 pyrroline-5-carboxylate reductase 1 0.595623
MC3R melanocortin 3 receptor 0.590948
IDE insulin-degrading enzyme 0.587444
GLP2R glucagon-like peptide 2 receptor 0.582773
PLSCR4 phospholipid scramblase 4 0.582384
SCARB1 scavenger receptor class B, member 1 0.58005
VPREB1 pre-B lymphocyte 1 0.578883
NEUROD1 neuronal differentiation 1 0.578883
TNF tumor necrosis factor 0.572662
PTH parathyroid hormone 0.572662
NWD1 NACHT and WD repeat domain containing 1 0.563723
SCARB2 scavenger receptor class B, member 2 0.563335
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.560227
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.555568
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.554403
C21ORF2 chromosome 21 open reading frame 2 0.551298
TBC1D4 TBC1 domain family, member 4 0.545093
GPR1 G protein-coupled receptor 1 0.540442
INPPL1 inositol polyphosphate phosphatase-like 1 0.535796
REN renin 0.531928
DOC2A double C2-like domains, alpha 0.529994
GPR26 G protein-coupled receptor 26 0.527676
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.52729
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.525746
BARHL2 BarH-like homeobox 2 0.525746
RICTOR RPTOR independent companion of MTOR, complex 2 0.525746
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.522659
CS citrate synthase 0.521888
CERS1 ceramide synthase 1 0.517649
APOC3 apolipoprotein C-III 0.516494
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.508041
PLSCR3 phospholipid scramblase 3 0.505356
RNF24 ring finger protein 24 0.501144
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.498849
HSDL1 hydroxysteroid dehydrogenase like 1 0.495793
MLXIPL MLX interacting protein-like 0.490072
MAPK8 mitogen-activated protein kinase 8 0.484744
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 0.484364
SH2B2 SH2B adaptor protein 2 0.482084
SCLY selenocysteine lyase 0.479807
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 0.477151
GJD2 gap junction protein, delta 2, 36kDa 0.476772
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 0.476772
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.474119
ITLN1 intelectin 1 (galactofuranose binding) 0.47374
TLR4 toll-like receptor 4 0.470711
MLX MLX, MAX dimerization protein 0.469197
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 0.468441
UNC13A unc-13 homolog A (C. elegans) 0.468063
NCOA5 nuclear receptor coactivator 5 0.467684
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.463905
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.461639
ASIC3 acid sensing (proton gated) ion channel 3 0.457864
ADGRF5 adhesion G protein-coupled receptor F5 0.457109
LIPC lipase, hepatic 0.452585
FAM3B family with sequence similarity 3, member B 0.444676
GH1 growth hormone 1 0.444676
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.440538
NPS neuropeptide S 0.424389
PCSK1 proprotein convertase subtilisin/kexin type 1 0.42139
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.42139
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.413901
PRL prolactin 0.413901
GAL galanin/GMAP prepropeptide 0.412031
FABP4 fatty acid binding protein 4, adipocyte 0.410909
SOD2 superoxide dismutase 2, mitochondrial 0.409787
GGT1 gamma-glutamyltransferase 1 0.407545
FAM64A family with sequence similarity 64, member A 0.403438
MBOAT4 membrane bound O-acyltransferase domain containing 4 0.401945
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.400826
FTO fat mass and obesity associated 0.398962
GFM2 G elongation factor, mitochondrial 2 0.398216
CCDC80 coiled-coil domain containing 80 0.397098
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.39598
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.390025
PYY peptide YY 0.388166
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.386679
CRH corticotropin releasing hormone 0.385565
NOS3 nitric oxide synthase 3 (endothelial cell) 0.385193
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.383708
TAS1R2 taste receptor, type 1, member 2 0.380368
IRG1 immunoresponsive 1 homolog (mouse) 0.378514
KIF12 kinesin family member 12 0.377773
PKLR pyruvate kinase, liver and RBC 0.372958
BGLAP bone gamma-carboxyglutamate (gla) protein 0.372587
PKM pyruvate kinase, muscle 0.372587
LGALS12 lectin, galactoside-binding, soluble, 12 0.371847
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.369997
CHIA chitinase, acidic 0.368888
MTMR9 myotubularin related protein 9 0.368518
PLIN1 perilipin 1 0.36704
GCGR glucagon receptor 0.365193
BRS3 bombesin-like receptor 3 0.357446
KLF3 Kruppel-like factor 3 (basic) 0.356709
GHR growth hormone receptor 0.352659
APOA1 apolipoprotein A-I 0.350084
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.34384
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.341272
CABIN1 calcineurin binding protein 1 0.341272
RIMS2 regulating synaptic membrane exocytosis 2 0.333583
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.333218
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.332487
BRD2 bromodomain containing 2 0.324094
WFS1 Wolfram syndrome 1 (wolframin) 0.321545
GGCT gamma-glutamylcyclotransferase 0.321181
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.318999
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.316456
CCK cholecystokinin 0.316456
FTL ferritin, light polypeptide 0.315366
FTH1 ferritin, heavy polypeptide 1 0.315366
GRP gastrin-releasing peptide 0.31464
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.312102
SESN3 sestrin 3 0.310652
PIR pirin (iron-binding nuclear protein) 0.30631
HCRT hypocretin (orexin) neuropeptide precursor 0.305948
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 0.305587
HNF1A HNF1 homeobox A 0.304503
ADRB3 adrenoceptor beta 3 0.303781
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.300533
NAGK N-acetylglucosamine kinase 0.299092
IGFBP3 insulin-like growth factor binding protein 3 0.296571
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.28616
PRKCD protein kinase C, delta 0.27794
MFN2 mitofusin 2 0.277584
NPAT nuclear protein, ataxia-telangiectasia locus 0.276514
LPA lipoprotein, Lp(a) 0.276158
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 0.274732
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.274021
APOE apolipoprotein E 0.273664
ATF6 activating transcription factor 6 0.272597
LYPLA1 lysophospholipase I 0.270819
RXFP4 relaxin/insulin-like family peptide receptor 4 0.269753
LDLR low density lipoprotein receptor 0.269753
TPCN2 two pore segment channel 2 0.267977
FOXM1 forkhead box M1 0.266203
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.26514
NSF N-ethylmaleimide-sensitive factor 0.264431
HAND2 heart and neural crest derivatives expressed 2 0.264077
CPT1C carnitine palmitoyltransferase 1C 0.261599
MLYCD malonyl-CoA decarboxylase 0.25983
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.259124
PLG plasminogen 0.258417
LMNA lamin A/C 0.257711
INSL5 insulin-like 5 0.255946
BTC betacellulin 0.255946
FNDC5 fibronectin type III domain containing 5 0.255946
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.253479
TCF19 transcription factor 19 0.251718
IGF2 insulin-like growth factor 2 0.251366
ESR1 estrogen receptor 1 0.251015
ERO1L ERO1-like (S. cerevisiae) 0.250663
CERS6 ceramide synthase 6 0.249257
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.246098
PYGB phosphorylase, glycogen; brain 0.245747
PYGL phosphorylase, glycogen, liver 0.242945
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.239101
FGF16 fibroblast growth factor 16 0.237706
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.237357
ALX3 ALX homeobox 3 0.235616
STK11 serine/threonine kinase 11 0.235268
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0.233183
NMB neuromedin B 0.232142
GHRH growth hormone releasing hormone 0.230063
DOCK7 dedicator of cytokinesis 7 0.229716
USF1 upstream transcription factor 1 0.227297
PRKX protein kinase, X-linked 0.226607
GUCA2B guanylate cyclase activator 2B (uroguanylin) 0.225917
CD68 CD68 molecule 0.222136
RAB3A RAB3A, member RAS oncogene family 0.221793
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.21974
PYGM phosphorylase, glycogen, muscle 0.219057
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.219057
VIP vasoactive intestinal peptide 0.218715
DNAH8 dynein, axonemal, heavy chain 8 0.218374
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.217693
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.215314
CCND2 cyclin D2 0.212608
USP2 ubiquitin specific peptidase 2 0.212608
SSTR5 somatostatin receptor 5 0.212271
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.211597
IGF1R insulin-like growth factor 1 receptor 0.210253
MGAM maltase-glucoamylase 0.207912
FBP1 fructose-1,6-bisphosphatase 1 0.207578
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.205916
OXR1 oxidation resistance 1 0.205254
GPR83 G protein-coupled receptor 83 0.204593
RGN regucalcin 0.202618
DDIT3 DNA-damage-inducible transcript 3 0.202618
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.201635
LPIN1 lipin 1 0.200982
OXT oxytocin/neurophysin I prepropeptide 0.200006
HSH2D hematopoietic SH2 domain containing 0.199356
TXN thioredoxin 0.197742
GPX1 glutathione peroxidase 1 0.197099
HNF1B HNF1 homeobox B 0.19582
DUSP9 dual specificity phosphatase 9 0.19582
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.195501
CAPN10 calpain 10 0.195183
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.195183
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.194865
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.194865
CRY1 cryptochrome circadian clock 1 0.1936
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.192971
ACACA acetyl-CoA carboxylase alpha 0.192344
CAT catalase 0.192031
ATG7 autophagy related 7 0.189859
RANBP3 RAN binding protein 3 0.189551
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.188326
RHOQ ras homolog family member Q 0.187113
SFRP5 secreted frizzled-related protein 5 0.18621
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 0.18591
ACADL acyl-CoA dehydrogenase, long chain 0.185612
CSN1S1 casein alpha s1 0.18472
PPARD peroxisome proliferator-activated receptor delta 0.184424
PLA2G16 phospholipase A2, group XVI 0.184128
GHSR growth hormone secretagogue receptor 0.183541
NKX2-2 NK2 homeobox 2 0.179239
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.179239
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 0.174617
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 0.173314
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.171785
GGTLC2 gamma-glutamyltransferase light chain 2 0.171785
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 0.171785
FOXD3 forkhead box D3 0.171286
GPR39 G protein-coupled receptor 39 0.170544
FOXP2 forkhead box P2 0.169812
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.169812
FOXO6 forkhead box O6 0.167452
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.167224
AFF2 AF4/FMR2 family, member 2 0.166319
SCG5 secretogranin V 0.166319
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2 0.166319
ACLY ATP citrate lyase 0.165655
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.163111
PLIN2 perilipin 2 0.161716
MTF1 metal-regulatory transcription factor 1 0.160761
GAST gastrin 0.160387
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 0.160203
SAR1A secretion associated, Ras related GTPase 1A 0.158778