glipizide-4991 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the glipizide-4991 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOB aldolase B, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ART1 ADP-ribosyltransferase 1
ATN1 atrophin 1
ATP10B ATPase, class V, type 10B
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BANK1 B-cell scaffold protein with ankyrin repeats 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C14ORF1 chromosome 14 open reading frame 1
C21ORF2 chromosome 21 open reading frame 2
CD58 CD58 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHN2 chimerin 2
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CUL7 cullin 7
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DAPK2 death-associated protein kinase 2
DFNB31 deafness, autosomal recessive 31
DGCR6L DiGeorge syndrome critical region gene 6-like
DMRT1 doublesex and mab-3 related transcription factor 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EDNRA endothelin receptor type A
FSCN1 fascin actin-bundling protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAS GNAS complex locus
GRPR gastrin-releasing peptide receptor
HAMP hepcidin antimicrobial peptide
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IL11 interleukin 11
IL1B interleukin 1, beta
IL2 interleukin 2
ITGA7 integrin, alpha 7
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNK10 potassium channel, two pore domain subfamily K, member 10
KRT19P2 keratin 19 pseudogene 2
LENEP lens epithelial protein
LGALS2 lectin, galactoside-binding, soluble, 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMF1 lipase maturation factor 1
LMF2 lipase maturation factor 2
LMX1B LIM homeobox transcription factor 1, beta
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPRE3 microtubule-associated protein, RP/EB family, member 3
METTL7A methyltransferase like 7A
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NAT6 N-acetyltransferase 6 (GCN5-related)
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PLXNB3 plexin B3
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRUNE2 prune homolog 2 (Drosophila)
RAPSN receptor-associated protein of the synapse
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RGS20 regulator of G-protein signaling 20
RHOBTB2 Rho-related BTB domain containing 2
RYR2 ryanodine receptor 2 (cardiac)
SCAND2P SCAN domain containing 2 pseudogene
SCN11A sodium channel, voltage gated, type XI alpha subunit
SECTM1 secreted and transmembrane 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERHL2 serine hydrolase-like 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SIX3 SIX homeobox 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SMC1A structural maintenance of chromosomes 1A
SPAG8 sperm associated antigen 8
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STAB2 stabilin 2
STATH statherin
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TK2 thymidine kinase 2, mitochondrial
TTLL3 tubulin tyrosine ligase-like family member 3
TYMS thymidylate synthetase
USP22 ubiquitin specific peptidase 22
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WIPF1 WAS/WASL interacting protein family, member 1
XAF1 XIAP associated factor 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF440 zinc finger protein 440
ZNF552 zinc finger protein 552
ZNF614 zinc finger protein 614
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTG2 actin, gamma 2, smooth muscle, enteric
ANKRD36 ankyrin repeat domain 36
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BAGE B melanoma antigen
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPRIN2 caprin family member 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CD302 CD302 molecule
CHD8 chromodomain helicase DNA binding protein 8
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIDEB cell death-inducing DFFA-like effector b
CRELD1 cysteine-rich with EGF-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF13 DDB1 and CUL4 associated factor 13
ECHDC3 enoyl CoA hydratase domain containing 3
FAM184A family with sequence similarity 184, member A
FBXO22 F-box protein 22
FCF1 FCF1 rRNA-processing protein
FEM1C fem-1 homolog c (C. elegans)
FER fer (fps/fes related) tyrosine kinase
FRK fyn-related Src family tyrosine kinase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLCE glucuronic acid epimerase
GPR1 G protein-coupled receptor 1
IL15RA interleukin 15 receptor, alpha
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5C lysine (K)-specific demethylase 5C
KIF13B kinesin family member 13B
KLHL9 kelch-like family member 9
LAMA3 laminin, alpha 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL2B methyltransferase like 2B
METTL8 methyltransferase like 8
MRPL2 mitochondrial ribosomal protein L2
MTA2 metastasis associated 1 family, member 2
N4BP3 NEDD4 binding protein 3
NME5 NME/NM23 family member 5
NPIPB3 nuclear pore complex interacting protein family, member B3
NPM3 nucleophosmin/nucleoplasmin 3
NT5E 5'-nucleotidase, ecto (CD73)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PROS1 protein S (alpha)
PYCRL pyrroline-5-carboxylate reductase-like
RAB3A RAB3A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RASA2 RAS p21 protein activator 2
RFTN1 raftlin, lipid raft linker 1
RNF122 ring finger protein 122
RNF146 ring finger protein 146
RNF170 ring finger protein 170
RNF25 ring finger protein 25
ROM1 retinal outer segment membrane protein 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRAGB Ras-related GTP binding B
SHROOM2 shroom family member 2
SIRT6 sirtuin 6
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TET3 tet methylcytosine dioxygenase 3
TOM1 target of myb1 (chicken)
TRIM66 tripartite motif containing 66
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN1 tetraspanin 1
TTBK2 tau tubulin kinase 2
TUBG2 tubulin, gamma 2
UBXN6 UBX domain protein 6
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR19 WD repeat domain 19
XK X-linked Kx blood group
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBED1 zinc finger, BED-type containing 1
ZBTB25 zinc finger and BTB domain containing 25
ZNF573 zinc finger protein 573
ZNF639 zinc finger protein 639
ZNF675 zinc finger protein 675
ZNF74 zinc finger protein 74
ZNF778 zinc finger protein 778
ZNF8 zinc finger protein 8
ZNRD1-AS1 ZNRD1 antisense RNA 1