glimepiride-6628 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the glimepiride-6628 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AIM2 absent in melanoma 2
ANGPTL4 angiopoietin-like 4
ARHGAP35 Rho GTPase activating protein 35
ARTN artemin
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BDKRB2 bradykinin receptor B2
BGN biglycan
C1QL1 complement component 1, q subcomponent-like 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CCDC181 coiled-coil domain containing 181
CD47 CD47 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CERS4 ceramide synthase 4
CHI3L2 chitinase 3-like 2
COBL cordon-bleu WH2 repeat protein
COL5A1 collagen, type V, alpha 1
CYTH3 cytohesin 3
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFNA3 ephrin-A3
EHD2 EH-domain containing 2
EXOC7 exocyst complex component 7
FABP4 fatty acid binding protein 4, adipocyte
FBXO41 F-box protein 41
FGFR1 fibroblast growth factor receptor 1
FLT1 fms-related tyrosine kinase 1
FUBP1 far upstream element (FUSE) binding protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GP6 glycoprotein VI (platelet)
GPR21 G protein-coupled receptor 21
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIK1 glutamate receptor, ionotropic, kainate 1
GSTTP1 glutathione S-transferase theta pseudogene 1
HAP1 huntingtin-associated protein 1
HIPK3 homeodomain interacting protein kinase 3
HIST1H3I histone cluster 1, H3i
HRG histidine-rich glycoprotein
HSF1 heat shock transcription factor 1
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDS iduronate 2-sulfatase
IFT122 intraflagellar transport 122
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCTD14 potassium channel tetramerization domain containing 14
KIF25 kinesin family member 25
KITLG KIT ligand
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LOC57399 uncharacterized gastric protein ZA52P
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAB21L1 mab-21-like 1 (C. elegans)
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NRCAM neuronal cell adhesion molecule
NRTN neurturin
NTNG1 netrin G1
PAPPA2 pappalysin 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PLCH2 phospholipase C, eta 2
PLIN2 perilipin 2
PLXNB2 plexin B2
POMT2 protein-O-mannosyltransferase 2
PPARD peroxisome proliferator-activated receptor delta
PRDM1 PR domain containing 1, with ZNF domain
PRKCA protein kinase C, alpha
PSG4 pregnancy specific beta-1-glycoprotein 4
PTCRA pre T-cell antigen receptor alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRB protein tyrosine phosphatase, receptor type, B
RASAL2 RAS protein activator like 2
RBM34 RNA binding motif protein 34
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS5 regulator of G-protein signaling 5
RPA4 replication protein A4, 30kDa
RPL35A ribosomal protein L35a
SAGE1 sarcoma antigen 1
SGK2 serum/glucocorticoid regulated kinase 2
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SSTR5 somatostatin receptor 5
STRA6 stimulated by retinoic acid 6
TFEB transcription factor EB
TGM4 transglutaminase 4
THOC5 THO complex 5
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRD T cell receptor delta locus
TRIM29 tripartite motif containing 29
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VGF VGF nerve growth factor inducible
ZNF280A zinc finger protein 280A
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ALPK1 alpha-kinase 1
ALS2CL ALS2 C-terminal like
AMPD2 adenosine monophosphate deaminase 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ANXA2P3 annexin A2 pseudogene 3
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BDNF brain-derived neurotrophic factor
C14ORF79 chromosome 14 open reading frame 79
CDON cell adhesion associated, oncogene regulated
CIDEB cell death-inducing DFFA-like effector b
CLCN5 chloride channel, voltage-sensitive 5
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CST1 cystatin SN
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DNAH17 dynein, axonemal, heavy chain 17
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM184A family with sequence similarity 184, member A
FLT4 fms-related tyrosine kinase 4
GALK1 galactokinase 1
GEMIN8 gem (nuclear organelle) associated protein 8
GIPC1 GIPC PDZ domain containing family, member 1
GRAMD1C GRAM domain containing 1C
HCFC2 host cell factor C2
HIST1H2AK histone cluster 1, H2ak
HIST1H2AM histone cluster 1, H2am
HIST1H3C histone cluster 1, H3c
HSPA1L heat shock 70kDa protein 1-like
IDI2-AS1 IDI2 antisense RNA 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIAA0895 KIAA0895
KIAA1456 KIAA1456
KIF1B kinesin family member 1B
LPAR4 lysophosphatidic acid receptor 4
MFSD12 major facilitator superfamily domain containing 12
MGP matrix Gla protein
MILR1 mast cell immunoglobulin-like receptor 1
MT1H metallothionein 1H
MYOZ3 myozenin 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDRG4 NDRG family member 4
NKX3-2 NK3 homeobox 2
NSUN6 NOP2/Sun domain family, member 6
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE8B phosphodiesterase 8B
PICK1 protein interacting with PRKCA 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLD2 phospholipase D2
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRF1 perforin 1 (pore forming protein)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF39 ring finger protein 39
SFMBT1 Scm-like with four mbt domains 1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC46A3 solute carrier family 46, member 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SP140L SP140 nuclear body protein-like
STARD13 StAR-related lipid transfer (START) domain containing 13
STIM1 stromal interaction molecule 1
SYNPO synaptopodin
TCTN2 tectonic family member 2
TKFC triokinase/FMN cyclase
TMEM183A transmembrane protein 183A
TMSB15A thymosin beta 15a
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM45 tripartite motif containing 45
TUBA4B tubulin, alpha 4b
ULBP2 UL16 binding protein 2
UNC119 unc-119 homolog (C. elegans)
WBP2 WW domain binding protein 2
XYLT2 xylosyltransferase II
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZFHX3 zinc finger homeobox 3
ZFP69B ZFP69 zinc finger protein B
ZNF141 zinc finger protein 141
ZNF227 zinc finger protein 227
ZNF276 zinc finger protein 276
ZNF282 zinc finger protein 282
ZNF286A zinc finger protein 286A
ZNF358 zinc finger protein 358
ZNF37BP zinc finger protein 37B, pseudogene
ZNF446 zinc finger protein 446