glimepiride-4973 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the glimepiride-4973 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARNT aryl hydrocarbon receptor nuclear translocator
BAIAP3 BAI1-associated protein 3
BMP5 bone morphogenetic protein 5
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCKAR cholecystokinin A receptor
CCNO cyclin O
CD52 CD52 molecule
CD82 CD82 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CEP250 centrosomal protein 250kDa
CNTFR ciliary neurotrophic factor receptor
CRY2 cryptochrome circadian clock 2
CSF1R colony stimulating factor 1 receptor
DCT dopachrome tautomerase
DNAI2 dynein, axonemal, intermediate chain 2
DOCK10 dedicator of cytokinesis 10
EFR3B EFR3 homolog B (S. cerevisiae)
ELAC2 elaC ribonuclease Z 2
FAM131A family with sequence similarity 131, member A
FAM46C family with sequence similarity 46, member C
FAM76A family with sequence similarity 76, member A
FBLN1 fibulin 1
FBN1 fibrillin 1
FOXI1 forkhead box I1
FYB FYN binding protein
GJB3 gap junction protein, beta 3, 31kDa
GLYAT glycine-N-acyltransferase
GPER1 G protein-coupled estrogen receptor 1
GPR153 G protein-coupled receptor 153
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGSF6 immunoglobulin superfamily, member 6
ITGA8 integrin, alpha 8
JAK3 Janus kinase 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK14 mitogen-activated protein kinase 14
MBNL3 muscleblind-like splicing regulator 3
MEGF6 multiple EGF-like-domains 6
MFGE8 milk fat globule-EGF factor 8 protein
MIER2 mesoderm induction early response 1, family member 2
MSX2 msh homeobox 2
MUC3A mucin 3A, cell surface associated
N4BP2L2-IT2 N4BPL2 intronic transcript 2
PAX5 paired box 5
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKNOX2 PBX/knotted 1 homeobox 2
PLAC4 placenta-specific 4
PLAU plasminogen activator, urokinase
PML promyelocytic leukemia
PTGIS prostaglandin I2 (prostacyclin) synthase
PVR poliovirus receptor
PVT1 Pvt1 oncogene (non-protein coding)
RAB6A RAB6A, member RAS oncogene family
RAD51 RAD51 recombinase
RANBP3 RAN binding protein 3
RPL10L ribosomal protein L10-like
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SAPCD1 suppressor APC domain containing 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SGK2 serum/glucocorticoid regulated kinase 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A16 solute carrier family 6, member 16
SMC4 structural maintenance of chromosomes 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPON1 spondin 1, extracellular matrix protein
STIM1 stromal interaction molecule 1
STMN4 stathmin-like 4
STON1 stonin 1
STX7 syntaxin 7
TBCD tubulin folding cofactor D
TCP11L1 t-complex 11, testis-specific-like 1
TESK1 testis-specific kinase 1
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TOR4A torsin family 4, member A
TREM1 triggering receptor expressed on myeloid cells 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPC5 transient receptor potential cation channel, subfamily C, member 5
UBE2I ubiquitin-conjugating enzyme E2I
VCAN versican
VIPR1 vasoactive intestinal peptide receptor 1
XYLB xylulokinase homolog (H. influenzae)
ZNF287 zinc finger protein 287
ZNF589 zinc finger protein 589
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BTBD2 BTB (POZ) domain containing 2
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX4 chromobox homolog 4
CD34 CD34 molecule
CD83 CD83 molecule
CGA glycoprotein hormones, alpha polypeptide
CHRM3 cholinergic receptor, muscarinic 3
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRIP1 cysteine-rich protein 1 (intestinal)
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DOC2A double C2-like domains, alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNA3 ephrin-A3
ELMO3 engulfment and cell motility 3
FAM155B family with sequence similarity 155, member B
FBXO4 F-box protein 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMD1 FERM domain containing 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNL1 guanine nucleotide binding protein-like 1
HDAC5 histone deacetylase 5
HIST1H2AI histone cluster 1, H2ai
HIST1H3E histone cluster 1, H3e
HOXA4 homeobox A4
HOXC10 homeobox C10
IFI27 interferon, alpha-inducible protein 27
IGSF1 immunoglobulin superfamily, member 1
IL1B interleukin 1, beta
ITGA10 integrin, alpha 10
JUNB jun B proto-oncogene
KIAA0125 KIAA0125
KIAA0754 KIAA0754
KIAA0922 KIAA0922
LMCD1 LIM and cysteine-rich domains 1
MAMLD1 mastermind-like domain containing 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MON1B MON1 secretory trafficking family member B
MVP major vault protein
MYF5 myogenic factor 5
NOL12 nucleolar protein 12
NPIPB3 nuclear pore complex interacting protein family, member B3
ONECUT2 one cut homeobox 2
PCDHB8 protocadherin beta 8
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCD1 phospholipase C, delta 1
PNPLA6 patatin-like phospholipase domain containing 6
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS53 protease, serine, 53
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRS protein tyrosine phosphatase, receptor type, S
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBM38 RNA binding motif protein 38
RCAN3 RCAN family member 3
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
S100A9 S100 calcium binding protein A9
SAA4 serum amyloid A4, constitutive
SAMD9 sterile alpha motif domain containing 9
SETD1A SET domain containing 1A
SLC12A8 solute carrier family 12, member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLMO1 slowmo homolog 1 (Drosophila)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
STX1A syntaxin 1A (brain)
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TBC1D19 TBC1 domain family, member 19
TMEM53 transmembrane protein 53
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRAIP TRAF interacting protein
TRIM25 tripartite motif containing 25
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VPS9D1 VPS9 domain containing 1
WLS wntless Wnt ligand secretion mediator
ZBTB22 zinc finger and BTB domain containing 22
ZBTB44 zinc finger and BTB domain containing 44