generalized anxiety disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation. (Human Disease Ontology, DOID_14320)
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Genes

117 genes co-occuring with the disease generalized anxiety disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 2.02159
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.54716
USP39 ubiquitin specific peptidase 39 1.42279
CRH corticotropin releasing hormone 1.18539
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.15666
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.12024
ADAD2 adenosine deaminase domain containing 2 1.11856
CRHR1 corticotropin releasing hormone receptor 1 1.09335
CAPS2 calcyphosine 2 0.997392
OIT3 oncoprotein induced transcript 3 0.982215
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.968761
ZDHHC9 zinc finger, DHHC-type containing 9 0.967083
GRM2 glutamate receptor, metabotropic 2 0.946603
MEA1 male-enhanced antigen 1 0.941611
PLXNA2 plexin A2 0.901567
RGS2 regulator of G-protein signaling 2 0.880243
PDLIM4 PDZ and LIM domain 4 0.878195
CCKBR cholecystokinin B receptor 0.877376
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.848716
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.846669
PAWR PRKC, apoptosis, WT1, regulator 0.819616
NUCB2 nucleobindin 2 0.819206
ADAT2 adenosine deaminase, tRNA-specific 2 0.818385
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.816334
MAOA monoamine oxidase A 0.815104
MYDGF myeloid-derived growth factor 0.805667
DCXR dicarbonyl/L-xylulose reductase 0.762271
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.761454
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.740299
TAS1R3 taste receptor, type 1, member 3 0.71078
LOR loricrin 0.706351
TOR1A torsin family 1, member A (torsin A) 0.693098
FAIM2 Fas apoptotic inhibitory molecule 2 0.692697
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.685891
BDNF brain-derived neurotrophic factor 0.672722
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.647743
AMY1B amylase, alpha 1B (salivary) 0.639857
AMY1A amylase, alpha 1A (salivary) 0.639857
AMY1C amylase, alpha 1C (salivary) 0.639857
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.623751
CORT cortistatin 0.604981
BPI bactericidal/permeability-increasing protein 0.604201
THAP1 THAP domain containing, apoptosis associated protein 1 0.60225
ARTN artemin 0.594064
CTNND2 catenin (cadherin-associated protein), delta 2 0.592895
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.589779
WRAP73 WD repeat containing, antisense to TP73 0.579272
AADACL3 arylacetamide deacetylase-like 3 0.576161
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.550911
NMS neuromedin S 0.545093
CUTA cutA divalent cation tolerance homolog (E. coli) 0.541992
TPH1 tryptophan hydroxylase 1 0.538118
TPRG1L tumor protein p63 regulated 1-like 0.529222
DRD2 dopamine receptor D2 0.525746
TACR1 tachykinin receptor 1 0.525746
TMEM51 transmembrane protein 51 0.521502
ATAD3A ATPase family, AAA domain containing 3A 0.499231
PPCS phosphopantothenoylcysteine synthetase 0.496557
POMC proopiomelanocortin 0.48893
SGCE sarcoglycan, epsilon 0.487788
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.482844
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.480566
COMT catechol-O-methyltransferase 0.471089
PSAP prosaposin 0.462772
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.453716
OPRK1 opioid receptor, kappa 1 0.452208
DRD1 dopamine receptor D1 0.448817
HARS histidyl-tRNA synthetase 0.440914
SIX5 SIX homeobox 5 0.434899
CRHR2 corticotropin releasing hormone receptor 2 0.430768
ASIC1 acid sensing (proton gated) ion channel 1 0.42814
FXYD1 FXYD domain containing ion transport regulator 1 0.421016
C6ORF25 chromosome 6 open reading frame 25 0.421016
ZAK sterile alpha motif and leucine zipper containing kinase AZK 0.415773
IVL involucrin 0.410161
LPP LIM domain containing preferred translocation partner in lipoma 0.409787
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.401945
JMJD6 jumonji domain containing 6 0.385565
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.377031
PHGDH phosphoglycerate dehydrogenase 0.371847
PDYN prodynorphin 0.370737
ALAD aminolevulinate dehydratase 0.365193
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.35892
OPRM1 opioid receptor, mu 1 0.337975
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 0.325187
PADI4 peptidyl arginine deiminase, type IV 0.317909
MAOB monoamine oxidase B 0.313552
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.311014
GP1BA glycoprotein Ib (platelet), alpha polypeptide 0.307033
NPY neuropeptide Y 0.303059
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.301254
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.300173
TAC1 tachykinin, precursor 1 0.298011
MARS methionyl-tRNA synthetase 0.294772
ICK intestinal cell (MAK-like) kinase 0.28151
SP6 Sp6 transcription factor 0.274732
LATS1 large tumor suppressor kinase 1 0.270464
EPHA4 EPH receptor A4 0.265849
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.258417
GRM1 glutamate receptor, metabotropic 1 0.250663
ADORA1 adenosine A1 receptor 0.247852
CCNA2 cyclin A2 0.246448
GSR glutathione reductase 0.244696
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.238403
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.235964
CCK cholecystokinin 0.233183
DRD3 dopamine receptor D3 0.227642
DRD4 dopamine receptor D4 0.222479
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.213621
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.202618
GCH1 GTP cyclohydrolase 1 0.199033
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 0.198709
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.180937
WDFY2 WD repeat and FYVE domain containing 2 0.17896
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.167452
PYY peptide YY 0.166095
GRM5 glutamate receptor, metabotropic 5 0.164786