geldanamycin-972 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the geldanamycin-972 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY7 adenylate cyclase 7
ADM adrenomedullin
AKAP17A A kinase (PRKA) anchor protein 17A
ANG angiogenin, ribonuclease, RNase A family, 5
ANXA1 annexin A1
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ATG13 autophagy related 13
BAG2 BCL2-associated athanogene 2
BMP4 bone morphogenetic protein 4
CACYBP calcyclin binding protein
CCNG2 cyclin G2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD1 cysteine-rich with EGF-like domains 1
CRELD2 cysteine-rich with EGF-like domains 2
CRY2 cryptochrome circadian clock 2
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EDRF1 erythroid differentiation regulatory factor 1
ERP44 endoplasmic reticulum protein 44
ETV5 ets variant 5
EXT1 exostosin glycosyltransferase 1
FBXO11 F-box protein 11
FGFR2 fibroblast growth factor receptor 2
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GOLGB1 golgin B1
GOLPH3L golgi phosphoprotein 3-like
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDM5A lysine (K)-specific demethylase 5A
LDLR low density lipoprotein receptor
LZTFL1 leucine zipper transcription factor-like 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MBNL2 muscleblind-like splicing regulator 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MON1B MON1 secretory trafficking family member B
NAP1L2 nucleosome assembly protein 1-like 2
NF2 neurofibromin 2 (merlin)
NUCB2 nucleobindin 2
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDIA4 protein disulfide isomerase family A, member 4
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLA2G3 phospholipase A2, group III
PPID peptidylprolyl isomerase D
PRSS16 protease, serine, 16 (thymus)
QKI QKI, KH domain containing, RNA binding
RGS2 regulator of G-protein signaling 2
RHOQ ras homolog family member Q
RNASE4 ribonuclease, RNase A family, 4
RRBP1 ribosome binding protein 1
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMG5 SMG5 nonsense mediated mRNA decay factor
TES testin LIM domain protein
TMEM50B transmembrane protein 50B
TRIM2 tripartite motif containing 2
TSPYL2 TSPY-like 2
ULBP2 UL16 binding protein 2
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF230 zinc finger protein 230
ZNF329 zinc finger protein 329

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD36B ankyrin repeat domain 36B
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP10 Rho GTPase activating protein 10
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
BIK BCL2-interacting killer (apoptosis-inducing)
C12ORF4 chromosome 12 open reading frame 4
C5ORF45 chromosome 5 open reading frame 45
C9ORF3 chromosome 9 open reading frame 3
CAPN15 calpain 15
CINP cyclin-dependent kinase 2 interacting protein
CLEC16A C-type lectin domain family 16, member A
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCAF16 DDB1 and CUL4 associated factor 16
DHRS3 dehydrogenase/reductase (SDR family) member 3
E2F8 E2F transcription factor 8
EFCAB2 EF-hand calcium binding domain 2
EFNA3 ephrin-A3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPHA4 EPH receptor A4
ERCC4 excision repair cross-complementation group 4
ETAA1 Ewing tumor-associated antigen 1
FAM160B2 family with sequence similarity 160, member B2
FAN1 FANCD2/FANCI-associated nuclease 1
FCHSD2 FCH and double SH3 domains 2
FKBP5 FK506 binding protein 5
FLJ10038 uncharacterized protein FLJ10038
FOXC1 forkhead box C1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GOLGA8B golgin A8 family, member B
GPR19 G protein-coupled receptor 19
HAUS2 HAUS augmin-like complex, subunit 2
HIST1H2BI histone cluster 1, H2bi
HPS6 Hermansky-Pudlak syndrome 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
JUNB jun B proto-oncogene
LIAS lipoic acid synthetase
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYPD1 LY6/PLAUR domain containing 1
MDM4 MDM4, p53 regulator
METTL2B methyltransferase like 2B
MNX1 motor neuron and pancreas homeobox 1
MTA2 metastasis associated 1 family, member 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
NECAB3 N-terminal EF-hand calcium binding protein 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPM3 nucleophosmin/nucleoplasmin 3
NPY5R neuropeptide Y receptor Y5
NR1D2 nuclear receptor subfamily 1, group D, member 2
OGFRL1 opioid growth factor receptor-like 1
OSMR oncostatin M receptor
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PARD6B par-6 family cell polarity regulator beta
PCF11 PCF11 cleavage and polyadenylation factor subunit
PLCG1 phospholipase C, gamma 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
RAB33B RAB33B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RCOR3 REST corepressor 3
RECQL4 RecQ protein-like 4
RGS16 regulator of G-protein signaling 16
RGS19 regulator of G-protein signaling 19
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RIBC2 RIB43A domain with coiled-coils 2
RPGR retinitis pigmentosa GTPase regulator
SCO2 SCO2 cytochrome c oxidase assembly protein
SETD6 SET domain containing 6
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNORA21 small nucleolar RNA, H/ACA box 21
SP140L SP140 nuclear body protein-like
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK16 serine/threonine kinase 16
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM159 transmembrane protein 159
TMEM260 transmembrane protein 260
TNRC6B trinucleotide repeat containing 6B
TPTE transmembrane phosphatase with tensin homology
TRAPPC12 trafficking protein particle complex 12
TRIM66 tripartite motif containing 66
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN15 tetraspanin 15
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF124 zinc finger protein 124
ZNF639 zinc finger protein 639
ZNF721 zinc finger protein 721
ZXDC ZXD family zinc finger C