geldanamycin-6187 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the geldanamycin-6187 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACAN aggrecan
ANXA6 annexin A6
AREG amphiregulin
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
BAG3 BCL2-associated athanogene 3
BAIAP2 BAI1-associated protein 2
CA5B carbonic anhydrase VB, mitochondrial
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP135 centrosomal protein 135kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CIITA class II, major histocompatibility complex, transactivator
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COL4A2 collagen, type IV, alpha 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRELD2 cysteine-rich with EGF-like domains 2
CREM cAMP responsive element modulator
CRYZ crystallin, zeta (quinone reductase)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP4 dual specificity phosphatase 4
EWSR1 EWS RNA-binding protein 1
FAM13A family with sequence similarity 13, member A
FAS Fas cell surface death receptor
FCAR Fc fragment of IgA receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGFR1 fibroblast growth factor receptor 1
FKBP4 FK506 binding protein 4, 59kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
GPR65 G protein-coupled receptor 65
GRAMD1B GRAM domain containing 1B
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IL7R interleukin 7 receptor
IQSEC1 IQ motif and Sec7 domain 1
KYNU kynureninase
MAGT1 magnesium transporter 1
MBNL2 muscleblind-like splicing regulator 2
MCTP2 multiple C2 domains, transmembrane 2
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSRB2 methionine sulfoxide reductase B2
MST1L macrophage stimulating 1-like
MT1HL1 metallothionein 1H-like 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OPTN optineurin
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PDIA4 protein disulfide isomerase family A, member 4
PHTF1 putative homeodomain transcription factor 1
PIR pirin (iron-binding nuclear protein)
PKN2 protein kinase N2
PPID peptidylprolyl isomerase D
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RPL10L ribosomal protein L10-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SMIM14 small integral membrane protein 14
SNAP23 synaptosomal-associated protein, 23kDa
SPAG5 sperm associated antigen 5
SPATS2L spermatogenesis associated, serine-rich 2-like
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
THBS1 thrombospondin 1
THEMIS2 thymocyte selection associated family member 2
TMEM50B transmembrane protein 50B
TPP1 tripeptidyl peptidase I
UGDH UDP-glucose 6-dehydrogenase
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APOL6 apolipoprotein L, 6
ARID5A AT rich interactive domain 5A (MRF1-like)
ARRB1 arrestin, beta 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C22ORF46 chromosome 22 open reading frame 46
C5ORF28 chromosome 5 open reading frame 28
C5ORF30 chromosome 5 open reading frame 30
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD3EAP CD3e molecule, epsilon associated protein
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COA7 cytochrome c oxidase assembly factor 7 (putative)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDN dendrin
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHRS1 dehydrogenase/reductase (SDR family) member 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENDOG endonuclease G
FAM127B family with sequence similarity 127, member B
FAM86B1 family with sequence similarity 86, member B1
FHOD1 formin homology 2 domain containing 1
FJX1 four jointed box 1 (Drosophila)
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLCE glucuronic acid epimerase
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HYAL3 hyaluronoglucosaminidase 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL24 interleukin 24
KIF21B kinesin family member 21B
KLF11 Kruppel-like factor 11
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP5 low density lipoprotein receptor-related protein 5
LTB lymphotoxin beta (TNF superfamily, member 3)
MAK16 MAK16 homolog (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NXT1 nuclear transport factor 2-like export factor 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEC plectin
PNO1 partner of NOB1 homolog (S. cerevisiae)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PQLC2 PQ loop repeat containing 2
PRAMEF11 PRAME family member 11
PRDM13 PR domain containing 13
PRICKLE3 prickle homolog 3 (Drosophila)
PROCR protein C receptor, endothelial
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTRH2 peptidyl-tRNA hydrolase 2
PUS1 pseudouridylate synthase 1
PUS7 pseudouridylate synthase 7 (putative)
PYCRL pyrroline-5-carboxylate reductase-like
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFXAP regulatory factor X-associated protein
RGS16 regulator of G-protein signaling 16
RGS19 regulator of G-protein signaling 19
RPP25 ribonuclease P/MRP 25kDa subunit
RRP1 ribosomal RNA processing 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SETD6 SET domain containing 6
SLC12A9 solute carrier family 12, member 9
SLC16A6 solute carrier family 16, member 6
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SURF2 surfeit 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
THRAP3 thyroid hormone receptor associated protein 3
TICAM1 toll-like receptor adaptor molecule 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNF tumor necrosis factor
UBIAD1 UbiA prenyltransferase domain containing 1
UNG uracil-DNA glycosylase
UPK3A uroplakin 3A
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XYLT2 xylosyltransferase II
ZBED8 zinc finger, BED-type containing 8
ZNF493 zinc finger protein 493