geldanamycin-4452 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the geldanamycin-4452 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI3BP ABI family, member 3 (NESH) binding protein
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACE2 angiotensin I converting enzyme 2
ACTN2 actinin, alpha 2
ADCY7 adenylate cyclase 7
ADRA1D adrenoceptor alpha 1D
ALPK3 alpha-kinase 3
ARHGAP28 Rho GTPase activating protein 28
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BTN3A1 butyrophilin, subfamily 3, member A1
C10ORF10 chromosome 10 open reading frame 10
C14ORF79 chromosome 14 open reading frame 79
CBS cystathionine-beta-synthase
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
COPE coatomer protein complex, subunit epsilon
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CRY2 cryptochrome circadian clock 2
CSNK1G1 casein kinase 1, gamma 1
CTH cystathionine gamma-lyase
DGKE diacylglycerol kinase, epsilon 64kDa
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EDRF1 erythroid differentiation regulatory factor 1
ERO1LB ERO1-like beta (S. cerevisiae)
ERP44 endoplasmic reticulum protein 44
F5 coagulation factor V (proaccelerin, labile factor)
FBN2 fibrillin 2
FLOT1 flotillin 1
FOXG1 forkhead box G1
GRAMD1B GRAM domain containing 1B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
HYOU1 hypoxia up-regulated 1
IFI44 interferon-induced protein 44
IL11 interleukin 11
IL7R interleukin 7 receptor
LIPG lipase, endothelial
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1B microtubule-associated protein 1B
MATN3 matrilin 3
MED25 mediator complex subunit 25
NCAPH2 non-SMC condensin II complex, subunit H2
NNMT nicotinamide N-methyltransferase
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDIA4 protein disulfide isomerase family A, member 4
PDZD2 PDZ domain containing 2
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
POU6F1 POU class 6 homeobox 1
PTPRR protein tyrosine phosphatase, receptor type, R
REEP2 receptor accessory protein 2
RFPL3 ret finger protein-like 3
RGCC regulator of cell cycle
SCN11A sodium channel, voltage gated, type XI alpha subunit
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETX senataxin
SF1 splicing factor 1
SIRPG signal-regulatory protein gamma
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMG7 SMG7 nonsense mediated mRNA decay factor
SNAP23 synaptosomal-associated protein, 23kDa
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
STK17B serine/threonine kinase 17b
TCP11L1 t-complex 11, testis-specific-like 1
TGFB2 transforming growth factor, beta 2
TMEM50B transmembrane protein 50B
TREM2 triggering receptor expressed on myeloid cells 2
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VWA5A von Willebrand factor A domain containing 5A
WIPF1 WAS/WASL interacting protein family, member 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFHX2 zinc finger homeobox 2
ZIC3 Zic family member 3
ZNF165 zinc finger protein 165
ZNF516 zinc finger protein 516
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ANKH ANKH inorganic pyrophosphate transport regulator
ANKZF1 ankyrin repeat and zinc finger domain containing 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BMP4 bone morphogenetic protein 4
BMPR1B bone morphogenetic protein receptor, type IB
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF68 chromosome 11 open reading frame 68
C17ORF53 chromosome 17 open reading frame 53
C1QTNF3 C1q and tumor necrosis factor related protein 3
CCNE1 cyclin E1
CCNE2 cyclin E2
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDT1 chromatin licensing and DNA replication factor 1
CENPT centromere protein T
CGREF1 cell growth regulator with EF-hand domain 1
CHAF1B chromatin assembly factor 1, subunit B (p60)
CNTLN centlein, centrosomal protein
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DDN dendrin
DENND2D DENN/MADD domain containing 2D
DEPDC5 DEP domain containing 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO1 exonuclease 1
FAM111A family with sequence similarity 111, member A
FBXL7 F-box and leucine-rich repeat protein 7
FBXO31 F-box protein 31
FKBP5 FK506 binding protein 5
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJC1 gap junction protein, gamma 1, 45kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC11 histone deacetylase 11
HIST1H3B histone cluster 1, H3b
HOXA4 homeobox A4
HOXA6 homeobox A6
HOXB2 homeobox B2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITGA10 integrin, alpha 10
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0319L KIAA0319-like
KLF4 Kruppel-like factor 4 (gut)
LIME1 Lck interacting transmembrane adaptor 1
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP5L low density lipoprotein receptor-related protein 5-like
MCC mutated in colorectal cancers
MCM10 minichromosome maintenance complex component 10
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDRG4 NDRG family member 4
NRTN neurturin
OLFML2B olfactomedin-like 2B
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
ORC1 origin recognition complex, subunit 1
OSMR oncostatin M receptor
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLA1A phospholipase A1 member A
PLD2 phospholipase D2
PLXNB3 plexin B3
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLL polymerase (DNA directed), lambda
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKG2 protein kinase, cGMP-dependent, type II
PTPRS protein tyrosine phosphatase, receptor type, S
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SCARA3 scavenger receptor class A, member 3
SH2B2 SH2B adaptor protein 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
STON1 stonin 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
THRAP3 thyroid hormone receptor associated protein 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM206 transmembrane protein 206
TOM1 target of myb1 (chicken)
TRIM9 tripartite motif containing 9
TRPV1 transient receptor potential cation channel, subfamily V, member 1
WNT16 wingless-type MMTV integration site family, member 16
ZBED8 zinc finger, BED-type containing 8
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF574 zinc finger protein 574
ZNF652 zinc finger protein 652