gamma-secretase complex Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. (Gene Ontology, GO_0070765)
External Link http://amigo.geneontology.org/amigo/term/GO:0070765
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Genes

3 proteins localized to the gamma-secretase complex cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
PSEN1 presenilin 1
PSENEN presenilin enhancer gamma secretase subunit
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)