gamma-secretase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. (Gene Ontology, GO_0070765)
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180 proteins co-occuring with the gamma-secretase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
NOTCH1 notch 1 3.42019
PSEN1 presenilin 1 3.13114
NCSTN nicastrin 3.10133
APH1A APH1A gamma secretase subunit 2.89153
PSENEN presenilin enhancer gamma secretase subunit 2.75966
BACE1 beta-site APP-cleaving enzyme 1 2.66913
APP amyloid beta (A4) precursor protein 2.58122
PSEN2 presenilin 2 1.95653
JAG1 jagged 1 1.81983
BACE2 beta-site APP-cleaving enzyme 2 1.65032
NOTCH2 notch 2 1.63658
ADAM10 ADAM metallopeptidase domain 10 1.62827
NOTCH2NL notch 2 N-terminal like 1.62768
HM13 histocompatibility (minor) 13 1.58852
NOTCH4 notch 4 1.56446
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 1.53218
DLL4 delta-like 4 (Drosophila) 1.39796
NOTCH3 notch 3 1.32817
HES5 hes family bHLH transcription factor 5 1.2809
ERBB4 erb-b2 receptor tyrosine kinase 4 1.27346
DLL1 delta-like 1 (Drosophila) 1.26974
RBPJ recombination signal binding protein for immunoglobulin kappa J region 1.26868
IDE insulin-degrading enzyme 1.25601
ADAM17 ADAM metallopeptidase domain 17 1.24341
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 1.1952
APLP1 amyloid beta (A4) precursor-like protein 1 1.16901
APLP2 amyloid beta (A4) precursor-like protein 2 1.1199
NCLN nicalin 1.07613
ZAK sterile alpha motif and leucine zipper containing kinase AZK 1.06498
JAG2 jagged 2 1.04431
MME membrane metallo-endopeptidase 1.01436
MAML1 mastermind-like 1 (Drosophila) 1.01387
APOE apolipoprotein E 0.997595
SPPL3 signal peptide peptidase like 3 0.995632
ICK intestinal cell (MAK-like) kinase 0.93785
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.935016
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.931716
SPPL2B signal peptide peptidase like 2B 0.925135
UBQLN1 ubiquilin 1 0.879633
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.830466
HEYL hes-related family bHLH transcription factor with YRPW motif-like 0.829089
ITM2B integral membrane protein 2B 0.825877
NGFR nerve growth factor receptor 0.8245
ADAM9 ADAM metallopeptidase domain 9 0.770907
DLK1 delta-like 1 homolog (Drosophila) 0.749999
APEH acylaminoacyl-peptide hydrolase 0.735115
LRP1B low density lipoprotein receptor-related protein 1B 0.73287
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.713682
KAT5 K(lysine) acetyltransferase 5 0.680719
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.679413
DLL3 delta-like 3 (Drosophila) 0.660345
DTX1 deltex 1, E3 ubiquitin ligase 0.65001
LDLR low density lipoprotein receptor 0.584686
FURIN furin (paired basic amino acid cleaving enzyme) 0.583849
EFNB2 ephrin-B2 0.5568
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.555145
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 0.52675
SPINK4 serine peptidase inhibitor, Kazal type 4 0.526341
CTSB cathepsin B 0.51327
CTSD cathepsin D 0.512862
LGALS4 lectin, galactoside-binding, soluble, 4 0.493775
TMEM102 transmembrane protein 102 0.482467
CRB2 crumbs family member 2 0.478843
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.471208
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.462798
NUMB numb homolog (Drosophila) 0.462798
ZMYM5 zinc finger, MYM-type 5 0.459602
TMEM147 transmembrane protein 147 0.458404
HES7 hes family bHLH transcription factor 7 0.457208
BSG basigin (Ok blood group) 0.454418
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.431435
CD44 CD44 molecule (Indian blood group) 0.429859
FLT1 fms-related tyrosine kinase 1 0.429072
DHCR24 24-dehydrocholesterol reductase 0.425138
ICAM5 intercellular adhesion molecule 5, telencephalin 0.423174
NGF nerve growth factor (beta polypeptide) 0.423174
POFUT1 protein O-fucosyltransferase 1 0.41886
NRG1 neuregulin 1 0.414555
TSPAN33 tetraspanin 33 0.408309
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 0.402859
NEUROG3 neurogenin 3 0.398199
MAPT microtubule-associated protein tau 0.395485
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.386979
TFCP2 transcription factor CP2 0.386593
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.37966
LAP3 leucine aminopeptidase 3 0.377354
ITM2C integral membrane protein 2C 0.372749
QPCT glutaminyl-peptide cyclotransferase 0.370067
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 0.36204
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 0.359752
SPON1 spondin 1, extracellular matrix protein 0.357086
ACHE acetylcholinesterase (Yt blood group) 0.351382
TNF tumor necrosis factor 0.347587
TP53 tumor protein p53 0.334733
SPPL2A signal peptide peptidase like 2A 0.329837
EGFR epidermal growth factor receptor 0.326078
GSK3B glycogen synthase kinase 3 beta 0.325327
PRNP prion protein 0.32195
MSX2 msh homeobox 2 0.320451
CFD complement factor D (adipsin) 0.314465
CTF1 cardiotrophin 1 0.313344
CD82 CD82 molecule 0.312597
VEGFA vascular endothelial growth factor A 0.311851
PTEN phosphatase and tensin homolog 0.309613
HES1 hes family bHLH transcription factor 1 0.309613
BCHE butyrylcholinesterase 0.302168
KLF4 Kruppel-like factor 4 (gut) 0.298455
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.29586
MAPK8 mitogen-activated protein kinase 8 0.294748
NRXN3 neurexin 3 0.292897
PROM1 prominin 1 0.289569
GPS1 G protein pathway suppressor 1 0.285138
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.285138
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.276671
NLE1 notchless homolog 1 (Drosophila) 0.2708
MMP25 matrix metallopeptidase 25 0.270068
SOX8 SRY (sex determining region Y)-box 8 0.265677
NOV nephroblastoma overexpressed 0.256197
MTCH1 mitochondrial carrier 1 0.252927
TAL1 T-cell acute lymphocytic leukemia 1 0.248216
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.247854
PREP prolyl endopeptidase 0.246046
CD4 CD4 molecule 0.240996
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 0.235249
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.232386
ATOH1 atonal homolog 1 (Drosophila) 0.231315
EPHB2 EPH receptor B2 0.229176
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.227041
LRP2 low density lipoprotein receptor-related protein 2 0.225622
CCND1 cyclin D1 0.225267
KRTCAP2 keratinocyte associated protein 2 0.22385
PTCRA pre T-cell antigen receptor alpha 0.220321
CH25H cholesterol 25-hydroxylase 0.214366
CHD3 chromodomain helicase DNA binding protein 3 0.212974
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.210894
RER1 retention in endoplasmic reticulum sorting receptor 1 0.209858
JUN jun proto-oncogene 0.208825
RELN reelin 0.205059
ALG3 ALG3, alpha-1,3- mannosyltransferase 0.199659
COL25A1 collagen, type XXV, alpha 1 0.199325
PICALM phosphatidylinositol binding clathrin assembly protein 0.197662
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.196669
CCR3 chemokine (C-C motif) receptor 3 0.18516
SDC3 syndecan 3 0.184241
HELT helt bHLH transcription factor 0.183935
HIST1H4D histone cluster 1, H4d 0.182723
HIST2H4A histone cluster 2, H4a 0.182723
HIST1H4H histone cluster 1, H4h 0.182723
HIST1H4I histone cluster 1, H4i 0.182723
HIST1H4J histone cluster 1, H4j 0.182723
HIST1H4K histone cluster 1, H4k 0.182723
HIST1H4A histone cluster 1, H4a 0.182723
HIST1H4F histone cluster 1, H4f 0.182723
HIST1H4E histone cluster 1, H4e 0.182723
HIST1H4C histone cluster 1, H4c 0.182723
HIST1H4B histone cluster 1, H4b 0.182723
HIST2H4B histone cluster 2, H4b 0.182723
HIST1H4L histone cluster 1, H4l 0.182422
HIST4H4 histone cluster 4, H4 0.182422
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.180045
NUMBL numb homolog (Drosophila)-like 0.178588
GPR3 G protein-coupled receptor 3 0.178011
NRG2 neuregulin 2 0.177724
EPHB4 EPH receptor B4 0.176587
CTNND2 catenin (cadherin-associated protein), delta 2 0.174911
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.172468
ATOH7 atonal homolog 7 (Drosophila) 0.171673
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.171149
CNTN2 contactin 2 (axonal) 0.171149
LMO1 LIM domain only 1 (rhombotin 1) 0.171149
VLDLR very low density lipoprotein receptor 0.170371
FGF20 fibroblast growth factor 20 0.16935
SELM selenoprotein M 0.167611
OLIG2 oligodendrocyte lineage transcription factor 2 0.167611
SREBF1 sterol regulatory element binding transcription factor 1 0.165697
AGER advanced glycosylation end product-specific receptor 0.159268
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.158315
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 0.157397
EGFL7 EGF-like-domain, multiple 7 0.157397
CTNND1 catenin (cadherin-associated protein), delta 1 0.156342