gamma chain deficiency Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A severe combined immunodeficiency that is a X-linked SCID caused by mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells. (Human Disease Ontology, DOID_0060013)
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Genes

67 genes co-occuring with the disease gamma chain deficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
IL2RG interleukin 2 receptor, gamma 2.92878
LMO2 LIM domain only 2 (rhombotin-like 1) 2.30033
JAK3 Janus kinase 3 1.63814
CD34 CD34 molecule 1.51677
ADA adenosine deaminase 1.49306
IL2RA interleukin 2 receptor, alpha 1.47989
IL2 interleukin 2 1.43947
IL7R interleukin 7 receptor 1.14433
CHD9 chromodomain helicase DNA binding protein 9 1.10006
PGK1 phosphoglycerate kinase 1 1.01723
BTK Bruton agammaglobulinemia tyrosine kinase 0.956196
JAK1 Janus kinase 1 0.94577
IL15RA interleukin 15 receptor, alpha 0.796642
IL21 interleukin 21 0.784755
SH2D1A SH2 domain containing 1A 0.773705
MECOM MDS1 and EVI1 complex locus 0.749237
TAL1 T-cell acute lymphocytic leukemia 1 0.732596
CD4 CD4 molecule 0.714408
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.694702
CD40LG CD40 ligand 0.67551
CBX3 chromobox homolog 3 0.650903
RAG1 recombination activating gene 1 0.634742
SLAMF6 SLAM family member 6 0.632777
IL15 interleukin 15 0.632384
USP6 ubiquitin specific peptidase 6 0.619442
RAG2 recombination activating gene 2 0.614747
FER fer (fps/fes related) tyrosine kinase 0.612792
CD40 CD40 molecule, TNF receptor superfamily member 5 0.59874
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.562558
IL4 interleukin 4 0.540829
DUSP5 dual specificity phosphatase 5 0.496175
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 0.495793
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.49274
LY6E lymphocyte antigen 6 complex, locus E 0.475634
ARAF A-Raf proto-oncogene, serine/threonine kinase 0.472604
STIL SCL/TAL1 interrupting locus 0.469954
WNT2B wingless-type MMTV integration site family, member 2B 0.455978
HOXB4 homeobox B4 0.43941
IL7 interleukin 7 0.43753
CFP complement factor properdin 0.430017
NCAM1 neural cell adhesion molecule 1 0.394491
TSLP thymic stromal lymphopoietin 0.373328
PRDM16 PR domain containing 16 0.349717
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.34384
CD19 CD19 molecule 0.327375
CRLF2 cytokine receptor-like factor 2 0.313552
AR androgen receptor 0.313552
CCND2 cyclin D2 0.304503
IL13 interleukin 13 0.303781
IL4R interleukin 4 receptor 0.291539
NOTCH1 notch 1 0.291539
CD27 CD27 molecule 0.26514
PKLR pyruvate kinase, liver and RBC 0.255594
PTPRC protein tyrosine phosphatase, receptor type, C 0.251015
IRAK1 interleukin-1 receptor-associated kinase 1 0.243995
HLA-C major histocompatibility complex, class I, C 0.237706
MEF2C myocyte enhancer factor 2C 0.235616
CRLF1 cytokine receptor-like factor 1 0.235268
VAV1 vav 1 guanine nucleotide exchange factor 0.227642
SOCS1 suppressor of cytokine signaling 1 0.215992
CD70 CD70 molecule 0.199033
PKM pyruvate kinase, muscle 0.196139
STAT5B signal transducer and activator of transcription 5B 0.194232
F9 coagulation factor IX 0.175679
MBL2 mannose-binding lectin (protein C) 2, soluble 0.172799
OTC ornithine carbamoyltransferase 0.172291
IRS1 insulin receptor substrate 1 0.164359