gabapentin-7229 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the gabapentin-7229 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
AIF1 allograft inflammatory factor 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARL4C ADP-ribosylation factor-like 4C
ARNT aryl hydrocarbon receptor nuclear translocator
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCDC57 coiled-coil domain containing 57
CCHCR1 coiled-coil alpha-helical rod protein 1
CDC25C cell division cycle 25C
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTSE cathepsin E
DIO2 deiodinase, iodothyronine, type II
DOK4 docking protein 4
DSTYK dual serine/threonine and tyrosine protein kinase
EGFR epidermal growth factor receptor
EXOC6B exocyst complex component 6B
FAM182B family with sequence similarity 182, member B
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF6 fibroblast growth factor 6
FLOT1 flotillin 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAS7 growth arrest-specific 7
GJA8 gap junction protein, alpha 8, 50kDa
GRIP2 glutamate receptor interacting protein 2
GRM8 glutamate receptor, metabotropic 8
HCRP1 hepatocellular carcinoma-related HCRP1
HFE hemochromatosis
HIST1H1E histone cluster 1, H1e
HIST1H2BN histone cluster 1, H2bn
HNF1A HNF1 homeobox A
HOXB6 homeobox B6
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFT122 intraflagellar transport 122
IFT22 intraflagellar transport 22
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IRS2 insulin receptor substrate 2
ITGA10 integrin, alpha 10
KDM4C lysine (K)-specific demethylase 4C
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAT2 linker for activation of T cells family, member 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOXL3 lysyl oxidase-like 3
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MCAM melanoma cell adhesion molecule
MMP25 matrix metallopeptidase 25
MMRN2 multimerin 2
MORN1 MORN repeat containing 1
MTA2 metastasis associated 1 family, member 2
NAAA N-acylethanolamine acid amidase
NEB nebulin
NEK9 NIMA-related kinase 9
NIPAL2 NIPA-like domain containing 2
NPR2 natriuretic peptide receptor 2
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PAX5 paired box 5
PCDHGA10 protocadherin gamma subfamily A, 10
PCM1 pericentriolar material 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PEX5 peroxisomal biogenesis factor 5
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK4 polo-like kinase 4
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRODH proline dehydrogenase (oxidase) 1
PRUNE2 prune homolog 2 (Drosophila)
PTPRA protein tyrosine phosphatase, receptor type, A
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RPL18 ribosomal protein L18
SCAPER S-phase cyclin A-associated protein in the ER
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SOX15 SRY (sex determining region Y)-box 15
SPN sialophorin
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYT5 synaptotagmin V
TK2 thymidine kinase 2, mitochondrial
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIB2 tribbles pseudokinase 2
TTC38 tetratricopeptide repeat domain 38
USP29 ubiquitin specific peptidase 29
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF117 zinc finger protein 117
ZNF136 zinc finger protein 136
ZNF362 zinc finger protein 362
ZNF407 zinc finger protein 407
ZNF749 zinc finger protein 749
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACAD10 acyl-CoA dehydrogenase family, member 10
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP13A2 ATPase type 13A2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAHD1 bromo adjacent homology domain containing 1
C4ORF29 chromosome 4 open reading frame 29
C5 complement component 5
CAMKMT calmodulin-lysine N-methyltransferase
CAMTA1 calmodulin binding transcription activator 1
CBX7 chromobox homolog 7
CBY1 chibby homolog 1 (Drosophila)
CCDC130 coiled-coil domain containing 130
CDKL3 cyclin-dependent kinase-like 3
CFAP69 cilia and flagella associated protein 69
CHIC2 cysteine-rich hydrophobic domain 2
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COL4A5 collagen, type IV, alpha 5
CRLF1 cytokine receptor-like factor 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERMAP erythroblast membrane-associated protein (Scianna blood group)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM169A family with sequence similarity 169, member A
FAM50B family with sequence similarity 50, member B
FAM63A family with sequence similarity 63, member A
FANCE Fanconi anemia, complementation group E
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FMO4 flavin containing monooxygenase 4
GLI3 GLI family zinc finger 3
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
IGSF1 immunoglobulin superfamily, member 1
IL15RA interleukin 15 receptor, alpha
IL17RB interleukin 17 receptor B
INF2 inverted formin, FH2 and WH2 domain containing
IRF7 interferon regulatory factor 7
KDM5C lysine (K)-specific demethylase 5C
KREMEN2 kringle containing transmembrane protein 2
LMNB1 lamin B1
LRRC20 leucine rich repeat containing 20
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAST3 microtubule associated serine/threonine kinase 3
METTL21B methyltransferase like 21B
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MORC3 MORC family CW-type zinc finger 3
NBEAL2 neurobeachin-like 2
NDE1 nudE neurodevelopment protein 1
NES nestin
OGFRL1 opioid growth factor receptor-like 1
PARD6A par-6 family cell polarity regulator alpha
PELI1 pellino E3 ubiquitin protein ligase 1
PGP phosphoglycolate phosphatase
PILRB paired immunoglobin-like type 2 receptor beta
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRKX protein kinase, X-linked
PYCRL pyrroline-5-carboxylate reductase-like
RASAL1 RAS protein activator like 1 (GAP1 like)
RBL1 retinoblastoma-like 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SAMD9 sterile alpha motif domain containing 9
SCAI suppressor of cancer cell invasion
SCAP SREBF chaperone
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC2A4RG SLC2A4 regulator
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STARD3 StAR-related lipid transfer (START) domain containing 3
SYNGR3 synaptogyrin 3
SYT17 synaptotagmin XVII
TBX19 T-box 19
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM104 transmembrane protein 104
TMEM132A transmembrane protein 132A
TMEM180 transmembrane protein 180
TMSB15A thymosin beta 15a
TOM1 target of myb1 (chicken)
TSPAN15 tetraspanin 15
TUBA3D tubulin, alpha 3d
UBXN6 UBX domain protein 6
UPP1 uridine phosphorylase 1
USB1 U6 snRNA biogenesis 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WBP1L WW domain binding protein 1-like
ZBTB48 zinc finger and BTB domain containing 48
ZNF14 zinc finger protein 14
ZNF16 zinc finger protein 16
ZNF268 zinc finger protein 268
ZNF492 zinc finger protein 492
ZNF552 zinc finger protein 552