furosemide-4503 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the furosemide-4503 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AMN amnion associated transmembrane protein
ANGPTL2 angiopoietin-like 2
ANKH ANKH inorganic pyrophosphate transport regulator
ANP32A-IT1 ANP32A intronic transcript 1
APAF1 apoptotic peptidase activating factor 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF7IP activating transcription factor 7 interacting protein
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BMP7 bone morphogenetic protein 7
C1ORF61 chromosome 1 open reading frame 61
CACFD1 calcium channel flower domain containing 1
CALD1 caldesmon 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC170 coiled-coil domain containing 170
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD68 CD68 molecule
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CLEC3B C-type lectin domain family 3, member B
CLEC4E C-type lectin domain family 4, member E
CRTC1 CREB regulated transcription coactivator 1
DCTN1 dynactin 1
DIAPH2 diaphanous-related formin 2
DLC1 DLC1 Rho GTPase activating protein
ELOVL2 ELOVL fatty acid elongase 2
ESR1 estrogen receptor 1
ETV1 ets variant 1
FAM63A family with sequence similarity 63, member A
FGF23 fibroblast growth factor 23
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GHRHR growth hormone releasing hormone receptor
GLB1L galactosidase, beta 1-like
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GRIK5 glutamate receptor, ionotropic, kainate 5
GRM7 glutamate receptor, metabotropic 7
HCRP1 hepatocellular carcinoma-related HCRP1
HFE hemochromatosis
HIST1H1D histone cluster 1, H1d
HPX hemopexin
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IFT122 intraflagellar transport 122
ING1 inhibitor of growth family, member 1
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDR kinase insert domain receptor
LRRC37A3 leucine rich repeat containing 37, member A3
MED18 mediator complex subunit 18
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MMP10 matrix metallopeptidase 10
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MSL3 male-specific lethal 3 homolog (Drosophila)
MYEF2 myelin expression factor 2
NLE1 notchless homolog 1 (Drosophila)
NOS1 nitric oxide synthase 1 (neuronal)
NPY neuropeptide Y
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PKP4 plakophilin 4
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRTN3 proteinase 3
PTPRJ protein tyrosine phosphatase, receptor type, J
RAD51B RAD51 paralog B
RAP1GAP RAP1 GTPase activating protein
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL35A ribosomal protein L35a
RPLP2 ribosomal protein, large, P2
SAYSD1 SAYSVFN motif domain containing 1
SEMG2 semenogelin II
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMG6 SMG6 nonsense mediated mRNA decay factor
SNAP25 synaptosomal-associated protein, 25kDa
SPHK2 sphingosine kinase 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN5 spectrin, beta, non-erythrocytic 5
SRSF6 serine/arginine-rich splicing factor 6
STAB2 stabilin 2
STK24 serine/threonine kinase 24
STRN3 striatin, calmodulin binding protein 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TET3 tet methylcytosine dioxygenase 3
TEX14 testis expressed 14
THNSL1 threonine synthase-like 1 (S. cerevisiae)
THSD4 thrombospondin, type I, domain containing 4
TMEM246 transmembrane protein 246
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
WSB1 WD repeat and SOCS box containing 1
ZBED4 zinc finger, BED-type containing 4
ZCCHC11 zinc finger, CCHC domain containing 11
ZFPM2 zinc finger protein, FOG family member 2
ZNF652 zinc finger protein 652
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
AADAC arylacetamide deacetylase
ABHD8 abhydrolase domain containing 8
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AHDC1 AT hook, DNA binding motif, containing 1
ANXA2P1 annexin A2 pseudogene 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BBC3 BCL2 binding component 3
BFSP1 beaded filament structural protein 1, filensin
C22ORF29 chromosome 22 open reading frame 29
C7ORF43 chromosome 7 open reading frame 43
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CCDC130 coiled-coil domain containing 130
CCNO cyclin O
CD70 CD70 molecule
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPT centromere protein T
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CIDEC cell death-inducing DFFA-like effector c
CISH cytokine inducible SH2-containing protein
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAGLA diacylglycerol lipase, alpha
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DGKD diacylglycerol kinase, delta 130kDa
DMTN dematin actin binding protein
EGF epidermal growth factor
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1LB ERO1-like beta (S. cerevisiae)
FAM110B family with sequence similarity 110, member B
FAM155A family with sequence similarity 155, member A
FRMD1 FERM domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAL3ST4 galactose-3-O-sulfotransferase 4
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GPATCH3 G patch domain containing 3
GPR19 G protein-coupled receptor 19
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRTP1 growth hormone regulated TBC protein 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
H1F0 H1 histone family, member 0
HDAC11 histone deacetylase 11
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KLHL36 kelch-like family member 36
LIN7B lin-7 homolog B (C. elegans)
LRP1 low density lipoprotein receptor-related protein 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYRM9 LYR motif containing 9
MAGEH1 melanoma antigen family H1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MMRN2 multimerin 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NID2 nidogen 2 (osteonidogen)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PLA2G1B phospholipase A2, group IB (pancreas)
PLD3 phospholipase D family, member 3
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLXNB3 plexin B3
PMPCA peptidase (mitochondrial processing) alpha
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
PTPRS protein tyrosine phosphatase, receptor type, S
RIBC2 RIB43A domain with coiled-coils 2
RNF122 ring finger protein 122
RPL13P5 ribosomal protein L13 pseudogene 5
SDC3 syndecan 3
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC46A3 solute carrier family 46, member 3
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMAD7 SMAD family member 7
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMO smoothened, frizzled class receptor
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STARD5 StAR-related lipid transfer (START) domain containing 5
SUN2 Sad1 and UNC84 domain containing 2
SYNGR3 synaptogyrin 3
TBXAS1 thromboxane A synthase 1 (platelet)
TMEM132A transmembrane protein 132A
USP20 ubiquitin specific peptidase 20
VARS valyl-tRNA synthetase
XYLT2 xylosyltransferase II
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF408 zinc finger protein 408
ZNF428 zinc finger protein 428
ZNF76 zinc finger protein 76