fumarate reductase complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). (Gene Ontology, GO_0045283)
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4 proteins localized to the fumarate reductase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.237908
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.237908
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.237908
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.237908