fulvestrant-7495 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the fulvestrant-7495 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
AASS aminoadipate-semialdehyde synthase
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4
ADCK2 aarF domain containing kinase 2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOC1 apolipoprotein C-I
ARRB2 arrestin, beta 2
ASB7 ankyrin repeat and SOCS box containing 7
ASIC1 acid sensing (proton gated) ion channel 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C9ORF156 chromosome 9 open reading frame 156
CA9 carbonic anhydrase IX
CALD1 caldesmon 1
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CIB2 calcium and integrin binding family member 2
CLU clusterin
CNTNAP1 contactin associated protein 1
COL3A1 collagen, type III, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
DHODH dihydroorotate dehydrogenase (quinone)
DMPK dystrophia myotonica-protein kinase
DMTN dematin actin binding protein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EN1 engrailed homeobox 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ETAA1 Ewing tumor-associated antigen 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FKBP10 FK506 binding protein 10, 65 kDa
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GALK1 galactokinase 1
GEMIN8 gem (nuclear organelle) associated protein 8
GLS2 glutaminase 2 (liver, mitochondrial)
HEMK1 HemK methyltransferase family member 1
HIF3A hypoxia inducible factor 3, alpha subunit
HOXC8 homeobox C8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IRS2 insulin receptor substrate 2
ISL1 ISL LIM homeobox 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD15 potassium channel tetramerization domain containing 15
KDM6A lysine (K)-specific demethylase 6A
KIAA0754 KIAA0754
KLF12 Kruppel-like factor 12
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
KRT6B keratin 6B, type II
LAMP1 lysosomal-associated membrane protein 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MDFIC MyoD family inhibitor domain containing
MEIS3P1 Meis homeobox 3 pseudogene 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAAA N-acylethanolamine acid amidase
NAT6 N-acetyltransferase 6 (GCN5-related)
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPY1R neuropeptide Y receptor Y1
PDE4DIP phosphodiesterase 4D interacting protein
PDZD2 PDZ domain containing 2
PKP2 plakophilin 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLL polymerase (DNA directed), lambda
PPP6R2 protein phosphatase 6, regulatory subunit 2
PTCRA pre T-cell antigen receptor alpha
PXMP4 peroxisomal membrane protein 4, 24kDa
RERE arginine-glutamic acid dipeptide (RE) repeats
RNASEH2B ribonuclease H2, subunit B
RWDD2A RWD domain containing 2A
S100A11 S100 calcium binding protein A11
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMR3A submaxillary gland androgen regulated protein 3A
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRT serrate, RNA effector molecule
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
ST7 suppression of tumorigenicity 7
STMN1 stathmin 1
SYNGR1 synaptogyrin 1
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TCTN1 tectonic family member 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM231 transmembrane protein 231
TMPRSS4 transmembrane protease, serine 4
UBTD1 ubiquitin domain containing 1
USP34 ubiquitin specific peptidase 34
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDHD1 WD repeat and HMG-box DNA binding protein 1
ZFX zinc finger protein, X-linked
ZNF639 zinc finger protein 639
ZNF778 zinc finger protein 778
ZNF783 zinc finger family member 783
ZNF84 zinc finger protein 84

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AMH anti-Mullerian hormone
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARRB1 arrestin, beta 1
ATG10 autophagy related 10
ATG2B autophagy related 2B
BAHCC1 BAH domain and coiled-coil containing 1
BBC3 BCL2 binding component 3
BMP4 bone morphogenetic protein 4
BSPRY B-box and SPRY domain containing
C2ORF54 chromosome 2 open reading frame 54
C8ORF44 chromosome 8 open reading frame 44
C9ORF40 chromosome 9 open reading frame 40
CARD9 caspase recruitment domain family, member 9
CCDC71 coiled-coil domain containing 71
CD70 CD70 molecule
CD82 CD82 molecule
CENPJ centromere protein J
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLSTN3 calsyntenin 3
CNTD2 cyclin N-terminal domain containing 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DAPK3 death-associated protein kinase 3
DEAF1 DEAF1 transcription factor
DEPDC5 DEP domain containing 5
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DOK2 docking protein 2, 56kDa
DUSP13 dual specificity phosphatase 13
DUSP2 dual specificity phosphatase 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKBP6 FK506 binding protein 6, 36kDa
FLT3 fms-related tyrosine kinase 3
FRMD1 FERM domain containing 1
FRMPD1 FERM and PDZ domain containing 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GDAP1 ganglioside induced differentiation associated protein 1
GMIP GEM interacting protein
GREB1L growth regulation by estrogen in breast cancer-like
HHLA1 HERV-H LTR-associating 1
HIST1H4B histone cluster 1, H4b
HOMER2 homer scaffolding protein 2
HOXA7 homeobox A7
HOXC4 homeobox C4
HSF4 heat shock transcription factor 4
INE1 inactivation escape 1 (non-protein coding)
IQCC IQ motif containing C
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KPNA4 karyopherin alpha 4 (importin alpha 3)
KREMEN2 kringle containing transmembrane protein 2
LGALS4 lectin, galactoside-binding, soluble, 4
LIPG lipase, endothelial
LRRK1 leucine-rich repeat kinase 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MARK1 MAP/microtubule affinity-regulating kinase 1
MMRN2 multimerin 2
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
NABP1 nucleic acid binding protein 1
NARFL nuclear prelamin A recognition factor-like
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPPA natriuretic peptide A
NR1I3 nuclear receptor subfamily 1, group I, member 3
OR7A10 olfactory receptor, family 7, subfamily A, member 10
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIP prolactin-induced protein
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLG plasminogen
PPEF1 protein phosphatase, EF-hand calcium binding domain 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPL10L ribosomal protein L10-like
RUSC2 RUN and SH3 domain containing 2
S100A5 S100 calcium binding protein A5
SCRG1 stimulator of chondrogenesis 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SETD8 SET domain containing (lysine methyltransferase) 8
SGPP1 sphingosine-1-phosphate phosphatase 1
SHPK sedoheptulokinase
SP4 Sp4 transcription factor
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SUGCT succinyl-CoA:glutarate-CoA transferase
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TENM1 teneurin transmembrane protein 1
TM4SF5 transmembrane 4 L six family member 5
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
WDR33 WD repeat domain 33
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF222 zinc finger protein 222
ZSCAN2 zinc finger and SCAN domain containing 2