fulvestrant-7096 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the fulvestrant-7096 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN4 actinin, alpha 4
ADD1 adducin 1 (alpha)
ATG3 autophagy related 3
ATP5SL ATP5S-like
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
C1ORF27 chromosome 1 open reading frame 27
C20ORF27 chromosome 20 open reading frame 27
C5ORF28 chromosome 5 open reading frame 28
CAMTA2 calmodulin binding transcription activator 2
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCDC93 coiled-coil domain containing 93
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CPT2 carnitine palmitoyltransferase 2
CRY1 cryptochrome circadian clock 1
CTSD cathepsin D
CUL9 cullin 9
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DUS2 dihydrouridine synthase 2
E2F1 E2F transcription factor 1
ECSIT ECSIT signalling integrator
FAIM Fas apoptotic inhibitory molecule
FAM127B family with sequence similarity 127, member B
FOXD1 forkhead box D1
FUBP1 far upstream element (FUSE) binding protein 1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GCFC2 GC-rich sequence DNA-binding factor 2
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
HAUS6 HAUS augmin-like complex, subunit 6
HDAC4 histone deacetylase 4
HEATR6 HEAT repeat containing 6
HNMT histamine N-methyltransferase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IL33 interleukin 33
IL6R interleukin 6 receptor
ISCA1 iron-sulfur cluster assembly 1
ITFG2 integrin alpha FG-GAP repeat containing 2
ITM2B integral membrane protein 2B
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KLF12 Kruppel-like factor 12
MANSC1 MANSC domain containing 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4 microtubule-associated protein 4
MDC1 mediator of DNA-damage checkpoint 1
MSRB2 methionine sulfoxide reductase B2
MTG1 mitochondrial ribosome-associated GTPase 1
N4BP2L2 NEDD4 binding protein 2-like 2
NDE1 nudE neurodevelopment protein 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NELFA negative elongation factor complex member A
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP50 nucleoporin 50kDa
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PELI1 pellino E3 ubiquitin protein ligase 1
PEX11A peroxisomal biogenesis factor 11 alpha
PLCE1 phospholipase C, epsilon 1
PLSCR1 phospholipid scramblase 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSPH phosphoserine phosphatase
PTCD2 pentatricopeptide repeat domain 2
PTHLH parathyroid hormone-like hormone
RAB29 RAB29, member RAS oncogene family
RANGAP1 Ran GTPase activating protein 1
RC3H2 ring finger and CCCH-type domains 2
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS19 regulator of G-protein signaling 19
RNF31 ring finger protein 31
RPS9 ribosomal protein S9
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
SCAF4 SR-related CTD-associated factor 4
SDHAF3 succinate dehydrogenase complex assembly factor 3
SETD6 SET domain containing 6
SIPA1 signal-induced proliferation-associated 1
SIX2 SIX homeobox 2
SLC25A44 solute carrier family 25, member 44
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNX24 sorting nexin 24
SPDEF SAM pointed domain containing ETS transcription factor
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SUGP2 SURP and G patch domain containing 2
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TCF12 transcription factor 12
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGM2 transglutaminase 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMED2 transmembrane emp24 domain trafficking protein 2
TSPAN31 tetraspanin 31
TTC33 tetratricopeptide repeat domain 33
UBE2I ubiquitin-conjugating enzyme E2I
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR82 WD repeat domain 82
WWTR1 WW domain containing transcription regulator 1
ZBTB44 zinc finger and BTB domain containing 44
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APOO apolipoprotein O
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATP13A2 ATPase type 13A2
ATXN2 ataxin 2
AXIN1 axin 1
BIK BCL2-interacting killer (apoptosis-inducing)
BSPRY B-box and SPRY domain containing
C16ORF59 chromosome 16 open reading frame 59
C2ORF42 chromosome 2 open reading frame 42
C9ORF91 chromosome 9 open reading frame 91
CFAP44 cilia and flagella associated protein 44
CHPF chondroitin polymerizing factor
CLSPN claspin
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COMMD9 COMM domain containing 9
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUTC cutC copper transporter
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DET1 de-etiolated homolog 1 (Arabidopsis)
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DTWD1 DTW domain containing 1
DUSP9 dual specificity phosphatase 9
ELP3 elongator acetyltransferase complex subunit 3
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FBXO46 F-box protein 46
FCHO1 FCH domain only 1
GAMT guanidinoacetate N-methyltransferase
GMPPB GDP-mannose pyrophosphorylase B
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HPS6 Hermansky-Pudlak syndrome 6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HYI hydroxypyruvate isomerase (putative)
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IRF9 interferon regulatory factor 9
KIAA1549L KIAA1549-like
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT4 keratin 4, type II
LMBR1L limb development membrane protein 1-like
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAPK3 mitogen-activated protein kinase 3
MCMBP minichromosome maintenance complex binding protein
MED9 mediator complex subunit 9
MFSD11 major facilitator superfamily domain containing 11
MGC12488
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MOSPD3 motile sperm domain containing 3
MPDU1 mannose-P-dolichol utilization defect 1
MTMR14 myotubularin related protein 14
NINJ1 ninjurin 1
NOL6 nucleolar protein 6 (RNA-associated)
OVGP1 oviductal glycoprotein 1, 120kDa
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAX6 paired box 6
PLCD1 phospholipase C, delta 1
PLD3 phospholipase D family, member 3
POM121 POM121 transmembrane nucleoporin
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PTCD1 pentatricopeptide repeat domain 1
RAB3A RAB3A, member RAS oncogene family
RNF113A ring finger protein 113A
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPL13P5 ribosomal protein L13 pseudogene 5
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNIP1 Smad nuclear interacting protein 1
SNORA21 small nucleolar RNA, H/ACA box 21
STARD13 StAR-related lipid transfer (START) domain containing 13
TAOK1 TAO kinase 1
TBC1D19 TBC1 domain family, member 19
TESK1 testis-specific kinase 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THBS3 thrombospondin 3
THOP1 thimet oligopeptidase 1
TICAM1 toll-like receptor adaptor molecule 1
TMEM104 transmembrane protein 104
TMEM53 transmembrane protein 53
TMEM62 transmembrane protein 62
TPK1 thiamin pyrophosphokinase 1
TRABD TraB domain containing
TRIM21 tripartite motif containing 21
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
VEZT vezatin, adherens junctions transmembrane protein
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZBTB25 zinc finger and BTB domain containing 25
ZFYVE16 zinc finger, FYVE domain containing 16
ZMAT5 zinc finger, matrin-type 5
ZNF136 zinc finger protein 136
ZNF350 zinc finger protein 350
ZNF654 zinc finger protein 654