fulvestrant-7091 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the fulvestrant-7091 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABR active BCR-related
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ARFRP1 ADP-ribosylation factor related protein 1
ATXN2L ataxin 2-like
BICD1 bicaudal D homolog 1 (Drosophila)
BTG2 BTG family, member 2
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
CA11 carbonic anhydrase XI
CCNG2 cyclin G2
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLCN7 chloride channel, voltage-sensitive 7
COL1A1 collagen, type I, alpha 1
CPQ carboxypeptidase Q
CST6 cystatin E/M
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EPHA3 EPH receptor A3
EPOR erythropoietin receptor
EPS8L1 EPS8-like 1
EXPH5 exophilin 5
F2R coagulation factor II (thrombin) receptor
FAM131A family with sequence similarity 131, member A
GDAP1 ganglioside induced differentiation associated protein 1
GLRX glutaredoxin (thioltransferase)
GRB7 growth factor receptor-bound protein 7
HDAC11 histone deacetylase 11
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ING1 inhibitor of growth family, member 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDM6A lysine (K)-specific demethylase 6A
KIF1C kinesin family member 1C
KIF22 kinesin family member 22
KRIT1 KRIT1, ankyrin repeat containing
LGALS8 lectin, galactoside-binding, soluble, 8
LMF2 lipase maturation factor 2
LONP2 lon peptidase 2, peroxisomal
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MTUS1 microtubule associated tumor suppressor 1
MXD4 MAX dimerization protein 4
NEK2 NIMA-related kinase 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OASL 2'-5'-oligoadenylate synthetase-like
OBSL1 obscurin-like 1
PARPBP PARP1 binding protein
PCDH1 protocadherin 1
PCDH7 protocadherin 7
PDE4DIP phosphodiesterase 4D interacting protein
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PEX14 peroxisomal biogenesis factor 14
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PML promyelocytic leukemia
PMP22 peripheral myelin protein 22
PNRC1 proline-rich nuclear receptor coactivator 1
POFUT1 protein O-fucosyltransferase 1
POGZ pogo transposable element with ZNF domain
PRUNE prune exopolyphosphatase
PTCD2 pentatricopeptide repeat domain 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PVT1 Pvt1 oncogene (non-protein coding)
RAB27B RAB27B, member RAS oncogene family
RBM8A RNA binding motif protein 8A
RECQL5 RecQ protein-like 5
RGS10 regulator of G-protein signaling 10
RNF25 ring finger protein 25
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SETD8 SET domain containing (lysine methyltransferase) 8
SF3A2 splicing factor 3a, subunit 2, 66kDa
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SPAG9 sperm associated antigen 9
SREBF2 sterol regulatory element binding transcription factor 2
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TBC1D22A TBC1 domain family, member 22A
TGM2 transglutaminase 2
TNK1 tyrosine kinase, non-receptor, 1
TRAF4 TNF receptor-associated factor 4
TRAIP TRAF interacting protein
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
UBXN1 UBX domain protein 1
ZNF16 zinc finger protein 16
ZNF350 zinc finger protein 350
ZNF467 zinc finger protein 467
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
ATF7IP2 activating transcription factor 7 interacting protein 2
BBS7 Bardet-Biedl syndrome 7
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L13 BCL2-like 13 (apoptosis facilitator)
C6ORF47 chromosome 6 open reading frame 47
C9ORF91 chromosome 9 open reading frame 91
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCDC57 coiled-coil domain containing 57
CCDC88C coiled-coil domain containing 88C
CCND1 cyclin D1
CD3EAP CD3e molecule, epsilon associated protein
CES3 carboxylesterase 3
CHUK conserved helix-loop-helix ubiquitous kinase
CISH cytokine inducible SH2-containing protein
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CUEDC1 CUE domain containing 1
CXCL12 chemokine (C-X-C motif) ligand 12
DSCAM Down syndrome cell adhesion molecule
DUSP13 dual specificity phosphatase 13
EGR3 early growth response 3
FAM102A family with sequence similarity 102, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXO22 F-box protein 22
FHL2 four and a half LIM domains 2
FOXC1 forkhead box C1
GBAS glioblastoma amplified sequence
GJA1 gap junction protein, alpha 1, 43kDa
GRTP1 growth hormone regulated TBC protein 1
GRWD1 glutamate-rich WD repeat containing 1
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IL15RA interleukin 15 receptor, alpha
IL17RB interleukin 17 receptor B
IREB2 iron-responsive element binding protein 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KREMEN2 kringle containing transmembrane protein 2
KRT13 keratin 13, type I
MANSC1 MANSC domain containing 1
METTL8 methyltransferase like 8
MICB MHC class I polypeptide-related sequence B
MITF microphthalmia-associated transcription factor
MPPED2 metallophosphoesterase domain containing 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NLK nemo-like kinase
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PPT2 palmitoyl-protein thioesterase 2
PRR3 proline rich 3
PTPRE protein tyrosine phosphatase, receptor type, E
PUS1 pseudouridylate synthase 1
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RHOBTB1 Rho-related BTB domain containing 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDCCAG3 serologically defined colon cancer antigen 3
SFMBT1 Scm-like with four mbt domains 1
SGK1 serum/glucocorticoid regulated kinase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SMAD7 SMAD family member 7
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNHG3 small nucleolar RNA host gene 3
SOAT1 sterol O-acyltransferase 1
SOX3 SRY (sex determining region Y)-box 3
SPAG4 sperm associated antigen 4
STARD13 StAR-related lipid transfer (START) domain containing 13
STC2 stanniocalcin 2
STK25 serine/threonine kinase 25
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM120B transmembrane protein 120B
TMEM121 transmembrane protein 121
TMEM164 transmembrane protein 164
TNRC6B trinucleotide repeat containing 6B
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TTC26 tetratricopeptide repeat domain 26
UBIAD1 UbiA prenyltransferase domain containing 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR3 WD repeat domain 3
XBP1 X-box binding protein 1
XK X-linked Kx blood group
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB39 zinc finger and BTB domain containing 39
ZBTB48 zinc finger and BTB domain containing 48
ZBTB6 zinc finger and BTB domain containing 6
ZFP30 ZFP30 zinc finger protein