fulvestrant-6997 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the fulvestrant-6997 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFAP1 actin filament associated protein 1
AHI1 Abelson helper integration site 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOLD1 apolipoprotein L domain containing 1
APOM apolipoprotein M
BGN biglycan
BTG2 BTG family, member 2
C19ORF73 chromosome 19 open reading frame 73
CAPN9 calpain 9
CCDC71 coiled-coil domain containing 71
CCDC93 coiled-coil domain containing 93
CCNG2 cyclin G2
CCP110 centriolar coiled coil protein 110kDa
CLCA1 chloride channel accessory 1
COL1A1 collagen, type I, alpha 1
COL8A1 collagen, type VIII, alpha 1
DLG5 discs, large homolog 5 (Drosophila)
DRD1 dopamine receptor D1
DSCR3 Down syndrome critical region 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EXTL3 exostosin-like glycosyltransferase 3
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FAM53B family with sequence similarity 53, member B
FBXL8 F-box and leucine-rich repeat protein 8
FER fer (fps/fes related) tyrosine kinase
FER1L4 fer-1-like family member 4, pseudogene (functional)
FLT4 fms-related tyrosine kinase 4
GK glycerol kinase
GOSR2 golgi SNAP receptor complex member 2
GPR137 G protein-coupled receptor 137
HAND1 heart and neural crest derivatives expressed 1
HIST1H2AI histone cluster 1, H2ai
HLA-E major histocompatibility complex, class I, E
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IL1R1 interleukin 1 receptor, type I
JMJD6 jumonji domain containing 6
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KLHL22 kelch-like family member 22
KRT83 keratin 83, type II
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LYN LYN proto-oncogene, Src family tyrosine kinase
MED12 mediator complex subunit 12
MED6 mediator complex subunit 6
MTM1 myotubularin 1
NCOA2 nuclear receptor coactivator 2
NDRG2 NDRG family member 2
NEBL nebulette
NIPAL2 NIPA-like domain containing 2
NUMA1 nuclear mitotic apparatus protein 1
ONECUT2 one cut homeobox 2
PAQR6 progestin and adipoQ receptor family member VI
PCDH9 protocadherin 9
PDE4C phosphodiesterase 4C, cAMP-specific
PHC3 polyhomeotic homolog 3 (Drosophila)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLG plasminogen
PLIN2 perilipin 2
PLN phospholamban
PRR4 proline rich 4 (lacrimal)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
QKI QKI, KH domain containing, RNA binding
RAB33B RAB33B, member RAS oncogene family
RBM19 RNA binding motif protein 19
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RND2 Rho family GTPase 2
RRBP1 ribosome binding protein 1
RTEL1 regulator of telomere elongation helicase 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCN10A sodium channel, voltage gated, type X alpha subunit
SH2B1 SH2B adaptor protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SNED1 sushi, nidogen and EGF-like domains 1
SOX2 SRY (sex determining region Y)-box 2
SPAG8 sperm associated antigen 8
SSPN sarcospan
TACC1 transforming, acidic coiled-coil containing protein 1
TMEM63A transmembrane protein 63A
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNK1 tyrosine kinase, non-receptor, 1
TPM1 tropomyosin 1 (alpha)
WSCD1 WSC domain containing 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF419 zinc finger protein 419
ZNF606 zinc finger protein 606

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ADCK3 aarF domain containing kinase 3
ADGRA3 adhesion G protein-coupled receptor A3
AEN apoptosis enhancing nuclease
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ATAD3A ATPase family, AAA domain containing 3A
ATF3 activating transcription factor 3
BPHL biphenyl hydrolase-like (serine hydrolase)
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C1ORF106 chromosome 1 open reading frame 106
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CDK3 cyclin-dependent kinase 3
CDR2L cerebellar degeneration-related protein 2-like
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CISH cytokine inducible SH2-containing protein
CLSPN claspin
CUEDC1 CUE domain containing 1
CXCL12 chemokine (C-X-C motif) ligand 12
DUSP5 dual specificity phosphatase 5
EFCAB2 EF-hand calcium binding domain 2
EGR3 early growth response 3
EXTL2 exostosin-like glycosyltransferase 2
FAM102A family with sequence similarity 102, member A
FAM155B family with sequence similarity 155, member B
FHL2 four and a half LIM domains 2
FMO4 flavin containing monooxygenase 4
FOSL1 FOS-like antigen 1
FRS2 fibroblast growth factor receptor substrate 2
GJA1 gap junction protein, alpha 1, 43kDa
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRWD1 glutamate-rich WD repeat containing 1
HAUS6 HAUS augmin-like complex, subunit 6
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IFT140 intraflagellar transport 140
IGFBP4 insulin-like growth factor binding protein 4
IGSF1 immunoglobulin superfamily, member 1
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIF16B kinesin family member 16B
KLF3 Kruppel-like factor 3 (basic)
KLHL21 kelch-like family member 21
KRT8P12 keratin 8 pseudogene 12
LOC100272216 uncharacterized LOC100272216
LZTR1 leucine-zipper-like transcription regulator 1
MBTD1 mbt domain containing 1
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MSX1 msh homeobox 1
MUM1 melanoma associated antigen (mutated) 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBEAL2 neurobeachin-like 2
NEK11 NIMA-related kinase 11
NES nestin
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
OXR1 oxidation resistance 1
P3H1 prolyl 3-hydroxylase 1
PACS1 phosphofurin acidic cluster sorting protein 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGP phosphoglycolate phosphatase
POLH polymerase (DNA directed), eta
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS1 pseudouridylate synthase 1
RAI14 retinoic acid induced 14
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
REPS2 RALBP1 associated Eps domain containing 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SIAH2 siah E3 ubiquitin protein ligase 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMAD7 SMAD family member 7
SPRYD7 SPRY domain containing 7
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM104 transmembrane protein 104
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSKU tsukushi, small leucine rich proteoglycan
TTC4 tetratricopeptide repeat domain 4
UNC119 unc-119 homolog (C. elegans)
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP18 ubiquitin specific peptidase 18
WDR62 WD repeat domain 62
YEATS2 YEATS domain containing 2
ZFP30 ZFP30 zinc finger protein
ZNF211 zinc finger protein 211
ZNF219 zinc finger protein 219
ZNF350 zinc finger protein 350
ZNF592 zinc finger protein 592