fulvestrant-6197 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the fulvestrant-6197 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABLIM1 actin binding LIM protein 1
ACAN aggrecan
ADCY9 adenylate cyclase 9
ADRA2C adrenoceptor alpha 2C
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOE apolipoprotein E
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BICD1 bicaudal D homolog 1 (Drosophila)
BMP10 bone morphogenetic protein 10
BMP8B bone morphogenetic protein 8b
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BTNL3 butyrophilin-like 3
C7ORF69 chromosome 7 open reading frame 69
C9ORF9 chromosome 9 open reading frame 9
CA5B carbonic anhydrase VB, mitochondrial
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CD200 CD200 molecule
CD68 CD68 molecule
CLTA clathrin, light chain A
CTSF cathepsin F
CYLD cylindromatosis (turban tumor syndrome)
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DMC1 DNA meiotic recombinase 1
DNAAF1 dynein, axonemal, assembly factor 1
DPP4 dipeptidyl-peptidase 4
DVL2 dishevelled segment polarity protein 2
ETV7 ets variant 7
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM134B family with sequence similarity 134, member B
FRMD8 FERM domain containing 8
FRS3 fibroblast growth factor receptor substrate 3
GDF5 growth differentiation factor 5
GJA4 gap junction protein, alpha 4, 37kDa
GJA8 gap junction protein, alpha 8, 50kDa
GLYAT glycine-N-acyltransferase
GRM8 glutamate receptor, metabotropic 8
HFE hemochromatosis
HIST1H2AJ histone cluster 1, H2aj
HIST1H3B histone cluster 1, H3b
HNF4A hepatocyte nuclear factor 4, alpha
HOXA3 homeobox A3
HOXA4 homeobox A4
HOXC11 homeobox C11
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IGF2-AS IGF2 antisense RNA
IGHD immunoglobulin heavy constant delta
INE1 inactivation escape 1 (non-protein coding)
IQSEC1 IQ motif and Sec7 domain 1
KDM4B lysine (K)-specific demethylase 4B
KEL Kell blood group, metallo-endopeptidase
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LMTK2 lemur tyrosine kinase 2
LOC730101 uncharacterized LOC730101
LRP1 low density lipoprotein receptor-related protein 1
MAN1A2 mannosidase, alpha, class 1A, member 2
MET MET proto-oncogene, receptor tyrosine kinase
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MLXIPL MLX interacting protein-like
MTUS1 microtubule associated tumor suppressor 1
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPRL1 opiate receptor-like 1
OSGIN2 oxidative stress induced growth inhibitor family member 2
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PCSK6 proprotein convertase subtilisin/kexin type 6
PLSCR3 phospholipid scramblase 3
PNPLA4 patatin-like phospholipase domain containing 4
PRB4 proline-rich protein BstNI subfamily 4
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGS12 regulator of G-protein signaling 12
RHBDD3 rhomboid domain containing 3
RHOBTB3 Rho-related BTB domain containing 3
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BP2 SH3-domain binding protein 2
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLIT2 slit homolog 2 (Drosophila)
SPTBN5 spectrin, beta, non-erythrocytic 5
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TSC22D4 TSC22 domain family, member 4
VEGFC vascular endothelial growth factor C
VPS13B vacuolar protein sorting 13 homolog B (yeast)
XYLB xylulokinase homolog (H. influenzae)
ZBTB17 zinc finger and BTB domain containing 17
ZBTB20 zinc finger and BTB domain containing 20
ZEB1 zinc finger E-box binding homeobox 1
ZNF444 zinc finger protein 444
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ADTRP androgen-dependent TFPI-regulating protein
AGBL5 ATP/GTP binding protein-like 5
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
APOL6 apolipoprotein L, 6
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATAT1 alpha tubulin acetyltransferase 1
BAHD1 bromo adjacent homology domain containing 1
BTBD18 BTB (POZ) domain containing 18
C2ORF54 chromosome 2 open reading frame 54
CAPN15 calpain 15
CBX7 chromobox homolog 7
CCDC71 coiled-coil domain containing 71
CCDC85C coiled-coil domain containing 85C
CCL21 chemokine (C-C motif) ligand 21
CDK3 cyclin-dependent kinase 3
COL9A2 collagen, type IX, alpha 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CORT cortistatin
CPA4 carboxypeptidase A4
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA4 ephrin-A4
EHD3 EH-domain containing 3
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPHB6 EPH receptor B6
EXD3 exonuclease 3'-5' domain containing 3
FAM120C family with sequence similarity 120C
FRMD1 FERM domain containing 1
GPR20 G protein-coupled receptor 20
HDAC11 histone deacetylase 11
HIST1H1T histone cluster 1, H1t
HIST1H2BJ histone cluster 1, H2bj
HIST1H4A histone cluster 1, H4a
HTRA1 HtrA serine peptidase 1
HYAL3 hyaluronoglucosaminidase 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFT81 intraflagellar transport 81
IGFBP4 insulin-like growth factor binding protein 4
IL12RB1 interleukin 12 receptor, beta 1
IL24 interleukin 24
INO80D INO80 complex subunit D
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
L2HGDH L-2-hydroxyglutarate dehydrogenase
LAMB3 laminin, beta 3
LINC00597 long intergenic non-protein coding RNA 597
LOC100286895 cell division cycle 27 homolog pseudogene
LRP5 low density lipoprotein receptor-related protein 5
MCOLN1 mucolipin 1
MEGF8 multiple EGF-like-domains 8
MPZ myelin protein zero
MRAS muscle RAS oncogene homolog
MYO15A myosin XVA
MYOZ1 myozenin 1
NPFFR1 neuropeptide FF receptor 1
PCBP4 poly(rC) binding protein 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE12 phosphodiesterase 12
PFN2 profilin 2
PGP phosphoglycolate phosphatase
PHOX2A paired-like homeobox 2a
POM121 POM121 transmembrane nucleoporin
PRICKLE3 prickle homolog 3 (Drosophila)
PRKCE protein kinase C, epsilon
PRY PTPN13-like, Y-linked
PSG4 pregnancy specific beta-1-glycoprotein 4
PYGB phosphorylase, glycogen; brain
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REPS2 RALBP1 associated Eps domain containing 2
RFXAP regulatory factor X-associated protein
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCD5 stearoyl-CoA desaturase 5
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC35F6 solute carrier family 35, member F6
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAOK1 TAO kinase 1
TBKBP1 TBK1 binding protein 1
TCTN1 tectonic family member 1
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TMEM246 transmembrane protein 246
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TRAF1 TNF receptor-associated factor 1
TTC4 tetratricopeptide repeat domain 4
TUBA3C tubulin, alpha 3c
TUBB2A tubulin, beta 2A class IIa
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR25 WD repeat domain 25
XYLT2 xylosyltransferase II
ZBTB25 zinc finger and BTB domain containing 25
ZNF177 zinc finger protein 177
ZNF862 zinc finger protein 862