fulvestrant-4429 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the fulvestrant-4429 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTA1 actin, alpha 1, skeletal muscle
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALOX15B arachidonate 15-lipoxygenase, type B
ANK2 ankyrin 2, neuronal
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APCS amyloid P component, serum
ARSA arylsulfatase A
ARTN artemin
C10ORF10 chromosome 10 open reading frame 10
CABP1 calcium binding protein 1
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CLCA1 chloride channel accessory 1
CLCN7 chloride channel, voltage-sensitive 7
CLSTN3 calsyntenin 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTTN cortactin
CYB5A cytochrome b5 type A (microsomal)
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DGKE diacylglycerol kinase, epsilon 64kDa
EDN3 endothelin 3
ELSPBP1 epididymal sperm binding protein 1
EMILIN2 elastin microfibril interfacer 2
ENG endoglin
EPHB1 EPH receptor B1
FAM135A family with sequence similarity 135, member A
FBXO2 F-box protein 2
FGF1 fibroblast growth factor 1 (acidic)
FGF9 fibroblast growth factor 9
FOXN2 forkhead box N2
GSPT1 G1 to S phase transition 1
GTPBP1 GTP binding protein 1
HDAC6 histone deacetylase 6
HFE hemochromatosis
HNF4A hepatocyte nuclear factor 4, alpha
HPSE2 heparanase 2 (inactive)
HSPG2 heparan sulfate proteoglycan 2
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGHMBP2 immunoglobulin mu binding protein 2
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
KALRN kalirin, RhoGEF kinase
KCNIP1 Kv channel interacting protein 1
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KSR1 kinase suppressor of ras 1
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LEF1 lymphoid enhancer-binding factor 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC157562 uncharacterized LOC157562
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP2BP LRP2 binding protein
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MEF2D myocyte enhancer factor 2D
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MST1 macrophage stimulating 1
MUC6 mucin 6, oligomeric mucus/gel-forming
NDRG2 NDRG family member 2
NPTX2 neuronal pentraxin II
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRL neural retina leucine zipper
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OLFM1 olfactomedin 1
OR7E24 olfactory receptor, family 7, subfamily E, member 24
PADI2 peptidyl arginine deiminase, type II
PCDHGB6 protocadherin gamma subfamily B, 6
PDPN podoplanin
PGK2 phosphoglycerate kinase 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLK3 polo-like kinase 3
PNPLA3 patatin-like phospholipase domain containing 3
PODNL1 podocan-like 1
PTAFR platelet-activating factor receptor
RAB33A RAB33A, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RUNX1 runt-related transcription factor 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SOX21 SRY (sex determining region Y)-box 21
TCP11L1 t-complex 11, testis-specific-like 1
TEF thyrotrophic embryonic factor
THSD4 thrombospondin, type I, domain containing 4
TJAP1 tight junction associated protein 1 (peripheral)
TPM3 tropomyosin 3
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TTC38 tetratricopeptide repeat domain 38
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR1 WD repeat domain 1
WNT6 wingless-type MMTV integration site family, member 6
ZFP2 ZFP2 zinc finger protein
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF334 zinc finger protein 334

decreased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
AGMAT agmatine ureohydrolase (agmatinase)
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALPK1 alpha-kinase 1
ARPIN actin-related protein 2/3 complex inhibitor
ATAD5 ATPase family, AAA domain containing 5
BMPR1B bone morphogenetic protein receptor, type IB
BTC betacellulin
BTF3P12 basic transcription factor 3 pseudogene 12
C16ORF45 chromosome 16 open reading frame 45
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1S complement component 1, s subcomponent
CA8 carbonic anhydrase VIII
CCDC186 coiled-coil domain containing 186
CHM choroideremia (Rab escort protein 1)
CLCN5 chloride channel, voltage-sensitive 5
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYB5R2 cytochrome b5 reductase 2
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DEPDC5 DEP domain containing 5
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP8 dual specificity phosphatase 8
ELP6 elongator acetyltransferase complex subunit 6
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FANCC Fanconi anemia, complementation group C
GINS4 GINS complex subunit 4 (Sld5 homolog)
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
HOXA4 homeobox A4
HOXA6 homeobox A6
HOXC4 homeobox C4
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INF2 inverted formin, FH2 and WH2 domain containing
INPPL1 inositol polyphosphate phosphatase-like 1
LIME1 Lck interacting transmembrane adaptor 1
LINS lines homolog (Drosophila)
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LRRC6 leucine rich repeat containing 6
MANBA mannosidase, beta A, lysosomal
MED18 mediator complex subunit 18
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MICALL2 MICAL-like 2
MILR1 mast cell immunoglobulin-like receptor 1
MMP13 matrix metallopeptidase 13
MTA2 metastasis associated 1 family, member 2
MX1 MX dynamin-like GTPase 1
NOTCH1 notch 1
NT5DC3 5'-nucleotidase domain containing 3
OLFML2B olfactomedin-like 2B
OVGP1 oviductal glycoprotein 1, 120kDa
PCBP4 poly(rC) binding protein 4
PCDHGB5 protocadherin gamma subfamily B, 5
PHEX phosphate regulating endopeptidase homolog, X-linked
PLXNA3 plexin A3
PODXL2 podocalyxin-like 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKG2 protein kinase, cGMP-dependent, type II
PRSS22 protease, serine, 22
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QSER1 glutamine and serine rich 1
RNF122 ring finger protein 122
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SKIL SKI-like proto-oncogene
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPIDR scaffolding protein involved in DNA repair
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNPO synaptopodin
SYT17 synaptotagmin XVII
TAOK1 TAO kinase 1
TEP1 telomerase-associated protein 1
THRB thyroid hormone receptor, beta
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TMEM180 transmembrane protein 180
TMEM53 transmembrane protein 53
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
VAV1 vav 1 guanine nucleotide exchange factor
VN1R1 vomeronasal 1 receptor 1
WNT16 wingless-type MMTV integration site family, member 16
ZNF358 zinc finger protein 358
ZNF37BP zinc finger protein 37B, pseudogene
ZNF652 zinc finger protein 652
ZNF702P zinc finger protein 702, pseudogene
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862