fulvestrant-2698 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the fulvestrant-2698 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACAA2 acetyl-CoA acyltransferase 2
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASCL1 achaete-scute family bHLH transcription factor 1
ASPH aspartate beta-hydroxylase
BLZF1 basic leucine zipper nuclear factor 1
BMP8B bone morphogenetic protein 8b
C11ORF63 chromosome 11 open reading frame 63
C3ORF14 chromosome 3 open reading frame 14
C7ORF26 chromosome 7 open reading frame 26
CALD1 caldesmon 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGA chromogranin A
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
CST1 cystatin SN
CXCL13 chemokine (C-X-C motif) ligand 13
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DST dystonin
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ERBB3 erb-b2 receptor tyrosine kinase 3
EVI5 ecotropic viral integration site 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM215A family with sequence similarity 215, member A (non-protein coding)
GDF10 growth differentiation factor 10
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HEG1 heart development protein with EGF-like domains 1
HGFAC HGF activator
HOXA4 homeobox A4
ICAM5 intercellular adhesion molecule 5, telencephalin
IGFBP7 insulin-like growth factor binding protein 7
IL12B interleukin 12B
IL17RC interleukin 17 receptor C
IL1RL1 interleukin 1 receptor-like 1
IL27RA interleukin 27 receptor, alpha
IRX4 iroquois homeobox 4
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA1045 KIAA1045
KIF1C kinesin family member 1C
KRT19P2 keratin 19 pseudogene 2
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LEP leptin
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LOC257152 uncharacterized LOC257152
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAST2 microtubule associated serine/threonine kinase 2
MAU2 MAU2 sister chromatid cohesion factor
MCTP2 multiple C2 domains, transmembrane 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MUC6 mucin 6, oligomeric mucus/gel-forming
MXRA8 matrix-remodelling associated 8
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NCAM1 neural cell adhesion molecule 1
NEK11 NIMA-related kinase 11
NF2 neurofibromin 2 (merlin)
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PARP3 poly (ADP-ribose) polymerase family, member 3
PBX2 pre-B-cell leukemia homeobox 2
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM5 PDZ and LIM domain 5
PFN2 profilin 2
PKP3 plakophilin 3
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PRB3 proline-rich protein BstNI subfamily 3
PRKCQ protein kinase C, theta
PRO2964 uncharacterized protein PRO2964
PRSS23 protease, serine, 23
PSD3 pleckstrin and Sec7 domain containing 3
RAB27B RAB27B, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RTEL1 regulator of telomere elongation helicase 1
RUFY3 RUN and FYVE domain containing 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIGLEC15 sialic acid binding Ig-like lectin 15
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SOX5 SRY (sex determining region Y)-box 5
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPON1 spondin 1, extracellular matrix protein
STAP1 signal transducing adaptor family member 1
SULF1 sulfatase 1
SULT4A1 sulfotransferase family 4A, member 1
TAPT1 transmembrane anterior posterior transformation 1
TBL1Y transducin (beta)-like 1, Y-linked
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMELESS timeless circadian clock
TLX3 T-cell leukemia homeobox 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAP2 ArfGAP with dual PH domains 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMT aminomethyltransferase
ANKRD7 ankyrin repeat domain 7
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ATAT1 alpha tubulin acetyltransferase 1
BCAS3 breast carcinoma amplified sequence 3
BDKRB1 bradykinin receptor B1
C1QTNF3 C1q and tumor necrosis factor related protein 3
C21ORF91 chromosome 21 open reading frame 91
C8ORF44 chromosome 8 open reading frame 44
C9ORF9 chromosome 9 open reading frame 9
CABP2 calcium binding protein 2
CBR3 carbonyl reductase 3
CCDC92 coiled-coil domain containing 92
CD34 CD34 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD82 CD82 molecule
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CPA2 carboxypeptidase A2 (pancreatic)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DPEP2 dipeptidase 2
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ERO1LB ERO1-like beta (S. cerevisiae)
EXO5 exonuclease 5
EXOSC1 exosome component 1
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBRS fibrosin
FOXN2 forkhead box N2
FSD1 fibronectin type III and SPRY domain containing 1
G0S2 G0/G1 switch 2
GALK1 galactokinase 1
GBP2 guanylate binding protein 2, interferon-inducible
GIF gastric intrinsic factor (vitamin B synthesis)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH3 G patch domain containing 3
GUCA2A guanylate cyclase activator 2A (guanylin)
HIST1H1E histone cluster 1, H1e
IL2 interleukin 2
INPP5K inositol polyphosphate-5-phosphatase K
KIAA1456 KIAA1456
KLF2 Kruppel-like factor 2
KRT8P12 keratin 8 pseudogene 12
LOC100131532 uncharacterized LOC100131532
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAGEH1 melanoma antigen family H1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MBTPS2 membrane-bound transcription factor peptidase, site 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
MXD3 MAX dimerization protein 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
OXCT2 3-oxoacid CoA transferase 2
PADI2 peptidyl arginine deiminase, type II
PECR peroxisomal trans-2-enoyl-CoA reductase
PHC1 polyhomeotic homolog 1 (Drosophila)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLAT plasminogen activator, tissue
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
POLL polymerase (DNA directed), lambda
PRDM12 PR domain containing 12
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTPRS protein tyrosine phosphatase, receptor type, S
RAP1GAP2 RAP1 GTPase activating protein 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RPS17P5 ribosomal protein S17 pseudogene 5
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A8 solute carrier family 12, member 8
SLC22A14 solute carrier family 22, member 14
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SPAG4 sperm associated antigen 4
SSBP3 single stranded DNA binding protein 3
STEAP4 STEAP family member 4
TMEM159 transmembrane protein 159
TMEM242 transmembrane protein 242
TOM1 target of myb1 (chicken)
TONSL tonsoku-like, DNA repair protein
TPM3 tropomyosin 3
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSPYL2 TSPY-like 2
URGCP upregulator of cell proliferation
VNN1 vanin 1
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZNF215 zinc finger protein 215
ZNF428 zinc finger protein 428
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747