fulvestrant-2665 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fulvestrant-2665 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABHD6 abhydrolase domain containing 6
ACPP acid phosphatase, prostate
ACSM3 acyl-CoA synthetase medium-chain family member 3
AMDHD2 amidohydrolase domain containing 2
ANGEL2 angel homolog 2 (Drosophila)
ANGPT2 angiopoietin 2
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
AQP9 aquaporin 9
ARID4B AT rich interactive domain 4B (RBP1-like)
ATXN2L ataxin 2-like
AURKA aurora kinase A
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BGLAP bone gamma-carboxyglutamate (gla) protein
BTN3A1 butyrophilin, subfamily 3, member A1
C1ORF68 chromosome 1 open reading frame 68
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAMTA2 calmodulin binding transcription activator 2
CAPN2 calpain 2, (m/II) large subunit
CARD10 caspase recruitment domain family, member 10
CAV2 caveolin 2
CCDC85C coiled-coil domain containing 85C
CES3 carboxylesterase 3
CRY2 cryptochrome circadian clock 2
CSN3 casein kappa
DCAF17 DDB1 and CUL4 associated factor 17
DCAF4 DDB1 and CUL4 associated factor 4
DOLK dolichol kinase
DUSP4 dual specificity phosphatase 4
EIF1 eukaryotic translation initiation factor 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPS8L1 EPS8-like 1
FAM105A family with sequence similarity 105, member A
FHL1 four and a half LIM domains 1
FST follistatin
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFRA1 GDNF family receptor alpha 1
GPATCH4 G patch domain containing 4
GRSF1 G-rich RNA sequence binding factor 1
GUK1 guanylate kinase 1
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HIPK3 homeodomain interacting protein kinase 3
HOXA1 homeobox A1
HOXA10 homeobox A10
IFI6 interferon, alpha-inducible protein 6
IL27RA interleukin 27 receptor, alpha
ING2 inhibitor of growth family, member 2
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCTD20 potassium channel tetramerization domain containing 20
KIF5C kinesin family member 5C
KRT24 keratin 24, type I
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LIMK2 LIM domain kinase 2
LMTK2 lemur tyrosine kinase 2
MAML3 mastermind-like 3 (Drosophila)
MAOA monoamine oxidase A
MAP4 microtubule-associated protein 4
MBNL2 muscleblind-like splicing regulator 2
MKL2 MKL/myocardin-like 2
MTUS1 microtubule associated tumor suppressor 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUPR1 nuclear protein, transcriptional regulator, 1
OAZ3 ornithine decarboxylase antizyme 3
OLIG2 oligodendrocyte lineage transcription factor 2
OSBPL10 oxysterol binding protein-like 10
PARP3 poly (ADP-ribose) polymerase family, member 3
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PLCD1 phospholipase C, delta 1
PLCG1 phospholipase C, gamma 1
POFUT1 protein O-fucosyltransferase 1
PPARA peroxisome proliferator-activated receptor alpha
PVR poliovirus receptor
RDX radixin
RHOB ras homolog family member B
RPAIN RPA interacting protein
RPL23AP32 ribosomal protein L23a pseudogene 32
SAP30 Sin3A-associated protein, 30kDa
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLAMF7 SLAM family member 7
SP140 SP140 nuclear body protein
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
STK3 serine/threonine kinase 3
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TM4SF20 transmembrane 4 L six family member 20
TMCC1 transmembrane and coiled-coil domain family 1
TMEM63A transmembrane protein 63A
TMPRSS6 transmembrane protease, serine 6
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRPS1 trichorhinophalangeal syndrome I
VPS9D1 VPS9 domain containing 1
WWTR1 WW domain containing transcription regulator 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARMCX4 armadillo repeat containing, X-linked 4
BCAR3 breast cancer anti-estrogen resistance 3
BTF3P12 basic transcription factor 3 pseudogene 12
C5AR1 complement component 5a receptor 1
C7ORF43 chromosome 7 open reading frame 43
C7ORF69 chromosome 7 open reading frame 69
C8A complement component 8, alpha polypeptide
C9ORF9 chromosome 9 open reading frame 9
CASS4 Cas scaffolding protein family member 4
CCDC92 coiled-coil domain containing 92
CCL27 chemokine (C-C motif) ligand 27
CCL4 chemokine (C-C motif) ligand 4
CCRL2 chemokine (C-C motif) receptor-like 2
CD79B CD79b molecule, immunoglobulin-associated beta
CDHR2 cadherin-related family member 2
CDK3 cyclin-dependent kinase 3
CDON cell adhesion associated, oncogene regulated
CENPB centromere protein B, 80kDa
CEP97 centrosomal protein 97kDa
CGA glycoprotein hormones, alpha polypeptide
CNN1 calponin 1, basic, smooth muscle
CROT carnitine O-octanoyltransferase
CRYGC crystallin, gamma C
CTNNBIP1 catenin, beta interacting protein 1
DDN dendrin
DOK3 docking protein 3
DSPP dentin sialophosphoprotein
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FBXL2 F-box and leucine-rich repeat protein 2
FGF23 fibroblast growth factor 23
FLT4 fms-related tyrosine kinase 4
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GIF gastric intrinsic factor (vitamin B synthesis)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR68 G protein-coupled receptor 68
HAMP hepcidin antimicrobial peptide
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BN histone cluster 1, H2bn
HIST1H3G histone cluster 1, H3g
HPR haptoglobin-related protein
IFNA14 interferon, alpha 14
IFT140 intraflagellar transport 140
IL2 interleukin 2
KDM8 lysine (K)-specific demethylase 8
KIAA1456 KIAA1456
KLHL36 kelch-like family member 36
KRT81 keratin 81, type II
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
METTL16 methyltransferase like 16
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MRAS muscle RAS oncogene homolog
MTSS1L metastasis suppressor 1-like
MXD3 MAX dimerization protein 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NKX3-2 NK3 homeobox 2
NNAT neuronatin
NPFFR1 neuropeptide FF receptor 1
NXF2 nuclear RNA export factor 2
P3H1 prolyl 3-hydroxylase 1
PIPOX pipecolic acid oxidase
PKD2L2 polycystic kidney disease 2-like 2
PLA2G1B phospholipase A2, group IB (pancreas)
PLAT plasminogen activator, tissue
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRF1 perforin 1 (pore forming protein)
RAB33B RAB33B, member RAS oncogene family
RAPSN receptor-associated protein of the synapse
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIN2 Ras and Rab interactor 2
RNF126P1 ring finger protein 126 pseudogene 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SIX3 SIX homeobox 3
SLC12A8 solute carrier family 12, member 8
SMR3A submaxillary gland androgen regulated protein 3A
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SYTL2 synaptotagmin-like 2
TMEM212 transmembrane protein 212
TMEM246 transmembrane protein 246
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNT1 troponin T type 1 (skeletal, slow)
TNS2 tensin 2
TRNAU1AP tRNA selenocysteine 1 associated protein 1
VEGFC vascular endothelial growth factor C
VN1R1 vomeronasal 1 receptor 1
ZNF623 zinc finger protein 623
ZNF668 zinc finger protein 668