fulvestrant-1076 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the fulvestrant-1076 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
AKAP13 A kinase (PRKA) anchor protein 13
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALAD aminolevulinate dehydratase
ALG12 ALG12, alpha-1,6-mannosyltransferase
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARHGAP35 Rho GTPase activating protein 35
ARID4A AT rich interactive domain 4A (RBP1-like)
ATP11A ATPase, class VI, type 11A
BCORL1 BCL6 corepressor-like 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDC14B cell division cycle 14B
CDR2L cerebellar degeneration-related protein 2-like
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CIC capicua transcriptional repressor
CLDN4 claudin 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
CORO1A coronin, actin binding protein, 1A
CUL7 cullin 7
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOHH deoxyhypusine hydroxylase/monooxygenase
DTNA dystrobrevin, alpha
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EIF3M eukaryotic translation initiation factor 3, subunit M
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA4 EPH receptor A4
EPHB3 EPH receptor B3
FBXL18 F-box and leucine-rich repeat protein 18
FKBP8 FK506 binding protein 8, 38kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GRAMD3 GRAM domain containing 3
GRB7 growth factor receptor-bound protein 7
GUSBP3 glucuronidase, beta pseudogene 3
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IL1R1 interleukin 1 receptor, type I
ING1 inhibitor of growth family, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM4A lysine (K)-specific demethylase 4A
KLHL24 kelch-like family member 24
LGALS8 lectin, galactoside-binding, soluble, 8
LIN7A lin-7 homolog A (C. elegans)
LPIN1 lipin 1
LPP LIM domain containing preferred translocation partner in lipoma
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPD3 LY6/PLAUR domain containing 3
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAN1A2 mannosidase, alpha, class 1A, member 2
MAP4 microtubule-associated protein 4
MBNL2 muscleblind-like splicing regulator 2
METTL5 methyltransferase like 5
MIR22HG MIR22 host gene
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCH1 phospholipase C, eta 1
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRMT2 protein arginine methyltransferase 2
PTBP3 polypyrimidine tract binding protein 3
R3HCC1L R3H domain and coiled-coil containing 1-like
REPS2 RALBP1 associated Eps domain containing 2
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RNMT RNA (guanine-7-) methyltransferase
SENP6 SUMO1/sentrin specific peptidase 6
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SIRT3 sirtuin 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SOAT1 sterol O-acyltransferase 1
SQSTM1 sequestosome 1
STK17B serine/threonine kinase 17b
STK25 serine/threonine kinase 25
STRN3 striatin, calmodulin binding protein 3
SYTL2 synaptotagmin-like 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLN1 talin 1
TMEM2 transmembrane protein 2
TNRC6B trinucleotide repeat containing 6B
TRA2A transformer 2 alpha homolog (Drosophila)
TRIM2 tripartite motif containing 2
TSPAN5 tetraspanin 5
UFL1 UFM1-specific ligase 1
USF2 upstream transcription factor 2, c-fos interacting
USP12 ubiquitin specific peptidase 12
VAMP4 vesicle-associated membrane protein 4
WIPI1 WD repeat domain, phosphoinositide interacting 1
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
AMPD2 adenosine monophosphate deaminase 2
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKRD28 ankyrin repeat domain 28
BACE1 beta-site APP-cleaving enzyme 1
C10ORF2 chromosome 10 open reading frame 2
C14ORF132 chromosome 14 open reading frame 132
C9ORF91 chromosome 9 open reading frame 91
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CCND1 cyclin D1
CCNJ cyclin J
CD3EAP CD3e molecule, epsilon associated protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP83 centrosomal protein 83kDa
CLK1 CDC-like kinase 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DBR1 debranching RNA lariats 1
DCK deoxycytidine kinase
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DKFZP586I1420 uncharacterized protein DKFZp586I1420
E2F6 E2F transcription factor 6
EGR3 early growth response 3
ERCC5 excision repair cross-complementation group 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM102A family with sequence similarity 102, member A
FAM188A family with sequence similarity 188, member A
FBXO46 F-box protein 46
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOXC1 forkhead box C1
GJA1 gap junction protein, alpha 1, 43kDa
GTPBP3 GTP binding protein 3 (mitochondrial)
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IRF7 interferon regulatory factor 7
IRX4 iroquois homeobox 4
ITGA6 integrin, alpha 6
KAT2A K(lysine) acetyltransferase 2A
KIAA1551 KIAA1551
KLF10 Kruppel-like factor 10
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP6D1 MAP6 domain containing 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MEX3C mex-3 RNA binding family member C
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMRK1 nicotinamide riboside kinase 1
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
PCNXL4 pecanex-like 4 (Drosophila)
PDZK1 PDZ domain containing 1
PEX11A peroxisomal biogenesis factor 11 alpha
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PRR7 proline rich 7 (synaptic)
PRSS23 protease, serine, 23
PUS1 pseudouridylate synthase 1
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAB17 RAB17, member RAS oncogene family
RAI14 retinoic acid induced 14
RALY RALY heterogeneous nuclear ribonucleoprotein
RAP1GAP2 RAP1 GTPase activating protein 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBBP8 retinoblastoma binding protein 8
RCL1 RNA terminal phosphate cyclase-like 1
RHOBTB1 Rho-related BTB domain containing 1
RNF25 ring finger protein 25
RPL23AP7 ribosomal protein L23a pseudogene 7
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SIAH2 siah E3 ubiquitin protein ligase 2
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC16A6 solute carrier family 16, member 6
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
SNHG20 small nucleolar RNA host gene 20
STC2 stanniocalcin 2
TESK1 testis-specific kinase 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM39A transmembrane protein 39A
TOLLIP toll interacting protein
TPBG trophoblast glycoprotein
TSKU tsukushi, small leucine rich proteoglycan
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR3 WD repeat domain 3
XBP1 X-box binding protein 1
ZBTB24 zinc finger and BTB domain containing 24
ZNF239 zinc finger protein 239
ZNF675 zinc finger protein 675
ZNF84 zinc finger protein 84
ZNHIT6 zinc finger, HIT-type containing 6