focal adhesion Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. (Gene Ontology, GO_0005925)
External Link http://amigo.geneontology.org/amigo/term/GO:0005925
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Genes

380 proteins localized to the focal adhesion cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ACTB actin, beta
ACTC1 actin, alpha, cardiac muscle 1
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACTN4 actinin, alpha 4
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADAM10 ADAM metallopeptidase domain 10
ADAM17 ADAM metallopeptidase domain 17
ADAM9 ADAM metallopeptidase domain 9
ADD1 adducin 1 (alpha)
ADGRE5 adhesion G protein-coupled receptor E5
AFAP1 actin filament associated protein 1
AHNAK AHNAK nucleoprotein
AIF1L allograft inflammatory factor 1-like
AJUBA ajuba LIM protein
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ANXA1 annexin A1
ANXA5 annexin A5
ANXA6 annexin A6
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARF1 ADP-ribosylation factor 1
ARF6 ADP-ribosylation factor 6
ARHGAP22 Rho GTPase activating protein 22
ARHGAP24 Rho GTPase activating protein 24
ARHGAP26 Rho GTPase activating protein 26
ARHGAP31 Rho GTPase activating protein 31
ARHGAP4 Rho GTPase activating protein 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATAT1 alpha tubulin acetyltransferase 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
B2M beta-2-microglobulin
BCAR1 breast cancer anti-estrogen resistance 1
BSG basigin (Ok blood group)
BSPRY B-box and SPRY domain containing
C2CD4B C2 calcium-dependent domain containing 4B
CALR calreticulin
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CAPN5 calpain 5
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CASS4 Cas scaffolding protein family member 4
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD151 CD151 molecule (Raph blood group)
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD59 CD59 molecule, complement regulatory protein
CD81 CD81 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CD99L2 CD99 molecule-like 2
CDC42 cell division cycle 42
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFL1 cofilin 1 (non-muscle)
CHP1 calcineurin-like EF-hand protein 1
CLTC clathrin, heavy chain (Hc)
CNN1 calponin 1, basic, smooth muscle
CNN2 calponin 2
CNN3 calponin 3, acidic
CORO1B coronin, actin binding protein, 1B
CORO1C coronin, actin binding protein, 1C
CSPG4 chondroitin sulfate proteoglycan 4
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCAF6 DDB1 and CUL4 associated factor 6
DDR2 discoidin domain receptor tyrosine kinase 2
DIXDC1 DIX domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DNM2 dynamin 2
DOCK7 dedicator of cytokinesis 7
DPP4 dipeptidyl-peptidase 4
DST dystonin
EBAG9 estrogen receptor binding site associated, antigen, 9
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EHD3 EH-domain containing 3
ENAH enabled homolog (Drosophila)
ENG endoglin
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA2 EPH receptor A2
EVL Enah/Vasp-like
EZR ezrin
FAP fibroblast activation protein, alpha
FAT1 FAT atypical cadherin 1
FBLIM1 filamin binding LIM protein 1
FBLN7 fibulin 7
FERMT1 fermitin family member 1
FERMT2 fermitin family member 2
FES FES proto-oncogene, tyrosine kinase
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FHL3 four and a half LIM domains 3
FLII flightless I homolog (Drosophila)
FLNA filamin A, alpha
FLNB filamin B, beta
FLNC filamin C, gamma
FLOT1 flotillin 1
FLOT2 flotillin 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FLT1 fms-related tyrosine kinase 1
FOCAD focadhesin
FZD1 frizzled class receptor 1
FZD2 frizzled class receptor 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAK cyclin G associated kinase
GDI2 GDP dissociation inhibitor 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GRB7 growth factor receptor-bound protein 7
GRK5 G protein-coupled receptor kinase 5
GSN gelsolin
HACD3 3-hydroxyacyl-CoA dehydratase 3
HCK HCK proto-oncogene, Src family tyrosine kinase
HMGA1 high mobility group AT-hook 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPG2 heparan sulfate proteoglycan 2
HYOU1 hypoxia up-regulated 1
ICAM1 intercellular adhesion molecule 1
IGF2R insulin-like growth factor 2 receptor
ILK integrin-linked kinase
IQGAP1 IQ motif containing GTPase activating protein 1
IRF2 interferon regulatory factor 2
ITGA1 integrin, alpha 1
ITGA11 integrin, alpha 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA8 integrin, alpha 8
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB1BP1 integrin beta 1 binding protein 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
JAK1 Janus kinase 1
JUP junction plakoglobin
KDM4B lysine (K)-specific demethylase 4B
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KRAS Kirsten rat sarcoma viral oncogene homolog
L1CAM L1 cell adhesion molecule
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LAP3 leucine aminopeptidase 3
LASP1 LIM and SH3 protein 1
LAYN layilin
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIG4 ligase IV, DNA, ATP-dependent
LIMA1 LIM domain and actin binding 1
LIMD1 LIM domains containing 1
LIMK1 LIM domain kinase 1
LIMS1 LIM and senescent cell antigen-like domains 1
LIMS2 LIM and senescent cell antigen-like domains 2
LMLN leishmanolysin-like (metallopeptidase M8 family)
LMO7 LIM domain 7
LPP LIM domain containing preferred translocation partner in lipoma
LPXN leupaxin
LRP1 low density lipoprotein receptor-related protein 1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MDC1 mediator of DNA-damage checkpoint 1
MISP mitotic spindle positioning
MME membrane metallo-endopeptidase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPRIP myosin phosphatase Rho interacting protein
MPZL1 myelin protein zero-like 1
MRC2 mannose receptor, C type 2
MSN moesin
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH9 myosin, heavy chain 9, non-muscle
NCKAP1 NCK-associated protein 1
NCSTN nicastrin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEXN nexilin (F actin binding protein)
NFASC neurofascin
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRP1 neuropilin 1
NUMB numb homolog (Drosophila)
NUP214 nucleoporin 214kDa
OPRM1 opioid receptor, mu 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC1 poly(A) binding protein, cytoplasmic 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALLD palladin, cytoskeletal associated protein
PARVA parvin, alpha
PARVB parvin, beta
PARVG parvin, gamma
PCBP2 poly(rC) binding protein 2
PDCD6IP programmed cell death 6 interacting protein
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM7 PDZ and LIM domain 7 (enigma)
PDPK1 3-phosphoinositide dependent protein kinase 1
PEAK1 pseudopodium-enriched atypical kinase 1
PFN1 profilin 1
PGM5 phosphoglucomutase 5
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEC plectin
PNMA1 paraneoplastic Ma antigen 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PROCR protein C receptor, endothelial
PRUNE prune exopolyphosphatase
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK7 protein tyrosine kinase 7 (inactive)
PTPRC protein tyrosine phosphatase, receptor type, C
PVR poliovirus receptor
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
PXN paxillin
RAB10 RAB10, member RAS oncogene family
RAB21 RAB21, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RDX radixin
REXO2 RNA exonuclease 2
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOG ras homolog family member G
RHOU ras homolog family member U
RND3 Rho family GTPase 3
RPL10A ribosomal protein L10a
RPL12 ribosomal protein L12
RPL13A ribosomal protein L13a
RPL18 ribosomal protein L18
RPL19 ribosomal protein L19
RPL22 ribosomal protein L22
RPL23 ribosomal protein L23
RPL27 ribosomal protein L27
RPL3 ribosomal protein L3
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPL4 ribosomal protein L4
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPL7A ribosomal protein L7a
RPL8 ribosomal protein L8
RPL9 ribosomal protein L9
RPLP0 ribosomal protein, large, P0
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS10 ribosomal protein S10
RPS11 ribosomal protein S11
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS15 ribosomal protein S15
RPS16 ribosomal protein S16
RPS17 ribosomal protein S17
RPS18 ribosomal protein S18
RPS19 ribosomal protein S19
RPS2 ribosomal protein S2
RPS29 ribosomal protein S29
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS5 ribosomal protein S5
RPS7 ribosomal protein S7
RPS8 ribosomal protein S8
RPS9 ribosomal protein S9
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSU1 Ras suppressor protein 1
S100A7 S100 calcium binding protein A7
SCARB2 scavenger receptor class B, member 2
SCARF2 scavenger receptor class F, member 2
SDC1 syndecan 1
SDC4 syndecan 4
SDCBP syndecan binding protein (syntenin)
SENP1 SUMO1/sentrin specific peptidase 1
SH3KBP1 SH3-domain kinase binding protein 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SNAP23 synaptosomal-associated protein, 23kDa
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SORBS1 sorbin and SH3 domain containing 1
SORBS3 sorbin and SH3 domain containing 3
SPRY4 sprouty homolog 4 (Drosophila)
SRCIN1 SRC kinase signaling inhibitor 1
SRP68 signal recognition particle 68kDa
STARD8 StAR-related lipid transfer (START) domain containing 8
STX16 syntaxin 16
SVIL supervillin
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNPO2 synaptopodin 2
TADA1 transcriptional adaptor 1
TEK TEK tyrosine kinase, endothelial
TES testin LIM domain protein
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGM2 transglutaminase 2
THY1 Thy-1 cell surface antigen
TLN1 talin 1
TLN2 talin 2
TNC tenascin C
TNS1 tensin 1
TNS2 tensin 2
TNS3 tensin 3
TNS4 tensin 4
TPM4 tropomyosin 4
TRIOBP TRIO and F-actin binding protein
TRIP6 thyroid hormone receptor interactor 6
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSPAN4 tetraspanin 4
TSPAN9 tetraspanin 9
TWF1 twinfilin actin binding protein 1
VASP vasodilator-stimulated phosphoprotein
VCL vinculin
VIM vimentin
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFYVE21 zinc finger, FYVE domain containing 21
ZNF185 zinc finger protein 185 (LIM domain)
ZNF384 zinc finger protein 384
ZYX zyxin