fluvoxamine-2913 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fluvoxamine-2913 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ADTRP androgen-dependent TFPI-regulating protein
ANO2 anoctamin 2, calcium activated chloride channel
AP3S2 adaptor-related protein complex 3, sigma 2 subunit
ARHGAP44 Rho GTPase activating protein 44
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BLZF1 basic leucine zipper nuclear factor 1
C5AR2 complement component 5a receptor 2
C7ORF69 chromosome 7 open reading frame 69
CC2D1A coiled-coil and C2 domain containing 1A
CD59 CD59 molecule, complement regulatory protein
CECR1 cat eye syndrome chromosome region, candidate 1
CEP41 centrosomal protein 41kDa
CHI3L2 chitinase 3-like 2
CLGN calmegin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL8A2 collagen, type VIII, alpha 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRAT carnitine O-acetyltransferase
CREBBP CREB binding protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCR3 chemokine (C-X-C motif) receptor 3
DMWD dystrophia myotonica, WD repeat containing
DRD2 dopamine receptor D2
EMILIN2 elastin microfibril interfacer 2
ETV7 ets variant 7
EXO5 exonuclease 5
F2R coagulation factor II (thrombin) receptor
FAM3A family with sequence similarity 3, member A
FAM86C1 family with sequence similarity 86, member C1
FOSL2 FOS-like antigen 2
FSTL1 follistatin-like 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GRIK5 glutamate receptor, ionotropic, kainate 5
GTDC1 glycosyltransferase-like domain containing 1
HRASLS2 HRAS-like suppressor 2
IFNW1 interferon, omega 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL5 interleukin 5
INA internexin neuronal intermediate filament protein, alpha
ITPK1 inositol-tetrakisphosphate 1-kinase
JAK3 Janus kinase 3
JUND jun D proto-oncogene
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KHSRP KH-type splicing regulatory protein
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLF5 Kruppel-like factor 5 (intestinal)
LAMC2 laminin, gamma 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMNA lamin A/C
MAPT microtubule-associated protein tau
MASP2 mannan-binding lectin serine peptidase 2
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MLXIP MLX interacting protein
MTL5 metallothionein-like 5, testis-specific (tesmin)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYL10 myosin, light chain 10, regulatory
NOS1 nitric oxide synthase 1 (neuronal)
NPFFR1 neuropeptide FF receptor 1
NUP88 nucleoporin 88kDa
NXPH3 neurexophilin 3
OPTN optineurin
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDHGA8 protocadherin gamma subfamily A, 8
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEG10 paternally expressed 10
PEX3 peroxisomal biogenesis factor 3
PIAS2 protein inhibitor of activated STAT, 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POU5F1P4 POU class 5 homeobox 1 pseudogene 4
POU6F1 POU class 6 homeobox 1
PRO2964 uncharacterized protein PRO2964
RAB6A RAB6A, member RAS oncogene family
SAMD4A sterile alpha motif domain containing 4A
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFTPC surfactant protein C
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SORBS3 sorbin and SH3 domain containing 3
SRCAP Snf2-related CREBBP activator protein
SSX1 synovial sarcoma, X breakpoint 1
ST7L suppression of tumorigenicity 7 like
SYNE2 spectrin repeat containing, nuclear envelope 2
TBX5 T-box 5
THAP3 THAP domain containing, apoptosis associated protein 3
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TYMP thymidine phosphorylase
UBTF upstream binding transcription factor, RNA polymerase I
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WDTC1 WD and tetratricopeptide repeats 1
ZNF177 zinc finger protein 177
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
APOBR apolipoprotein B receptor
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARHGAP12 Rho GTPase activating protein 12
ASGR2 asialoglycoprotein receptor 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BATF basic leucine zipper transcription factor, ATF-like
BBS7 Bardet-Biedl syndrome 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CBX4 chromobox homolog 4
CCNT1 cyclin T1
CD300C CD300c molecule
CHM choroideremia (Rab escort protein 1)
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRIP1 cysteine-rich protein 1 (intestinal)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKZ diacylglycerol kinase, zeta
DNAAF2 dynein, axonemal, assembly factor 2
DOLK dolichol kinase
ECM1 extracellular matrix protein 1
ECSIT ECSIT signalling integrator
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FAM86B1 family with sequence similarity 86, member B1
FBRS fibrosin
GJA1 gap junction protein, alpha 1, 43kDa
GK3P glycerol kinase 3 pseudogene
GRAMD1B GRAM domain containing 1B
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
HIRA histone cell cycle regulator
HIST1H2BC histone cluster 1, H2bc
INF2 inverted formin, FH2 and WH2 domain containing
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIF24 kinesin family member 24
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC37A2 leucine rich repeat containing 37, member A2
LTB4R leukotriene B4 receptor
MANSC1 MANSC domain containing 1
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MATK megakaryocyte-associated tyrosine kinase
MED15 mediator complex subunit 15
METTL16 methyltransferase like 16
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MLYCD malonyl-CoA decarboxylase
MRGBP MRG/MORF4L binding protein
MTERF4 mitochondrial transcription termination factor 4
MXD3 MAX dimerization protein 3
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NME6 NME/NM23 nucleoside diphosphate kinase 6
NUBPL nucleotide binding protein-like
PARP16 poly (ADP-ribose) polymerase family, member 16
PARPBP PARP1 binding protein
PBLD phenazine biosynthesis-like protein domain containing
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PTH2R parathyroid hormone 2 receptor
RBM41 RNA binding motif protein 41
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
RPA4 replication protein A4, 30kDa
SARS2 seryl-tRNA synthetase 2, mitochondrial
SEC31B SEC31 homolog B (S. cerevisiae)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SERGEF secretion regulating guanine nucleotide exchange factor
SHPK sedoheptulokinase
SKI SKI proto-oncogene
SLC12A9 solute carrier family 12, member 9
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLFN12 schlafen family member 12
SLITRK5 SLIT and NTRK-like family, member 5
SMA4 glucuronidase, beta pseudogene
SNHG20 small nucleolar RNA host gene 20
SPAG4 sperm associated antigen 4
SPRYD7 SPRY domain containing 7
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TGM5 transglutaminase 5
THAP10 THAP domain containing 10
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TLN1 talin 1
TMEM134 transmembrane protein 134
TMEM254 transmembrane protein 254
TRABD TraB domain containing
TRDMT1 tRNA aspartic acid methyltransferase 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
UPP1 uridine phosphorylase 1
URM1 ubiquitin related modifier 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZMAT3 zinc finger, matrin-type 3
ZNF12 zinc finger protein 12
ZNF225 zinc finger protein 225
ZNF493 zinc finger protein 493