fluvastatin-3370 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the fluvastatin-3370 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACACB acetyl-CoA carboxylase beta
ACPP acid phosphatase, prostate
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ANGPTL2 angiopoietin-like 2
ARC activity-regulated cytoskeleton-associated protein
BIN1 bridging integrator 1
BLNK B-cell linker
BMP1 bone morphogenetic protein 1
C1ORF95 chromosome 1 open reading frame 95
C4BPA complement component 4 binding protein, alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAPZB capping protein (actin filament) muscle Z-line, beta
CCDC64 coiled-coil domain containing 64
CEL carboxyl ester lipase
CEP135 centrosomal protein 135kDa
CFHR4 complement factor H-related 4
CLCN7 chloride channel, voltage-sensitive 7
COL6A1 collagen, type VI, alpha 1
CST2 cystatin SA
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DGCR8 DGCR8 microprocessor complex subunit
DRICH1 aspartate-rich 1
EHD2 EH-domain containing 2
ELP6 elongator acetyltransferase complex subunit 6
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
F13A1 coagulation factor XIII, A1 polypeptide
FASLG Fas ligand (TNF superfamily, member 6)
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGT1 gamma-glutamyltransferase 1
GLP1R glucagon-like peptide 1 receptor
GM2A GM2 ganglioside activator
GP2 glycoprotein 2 (zymogen granule membrane)
GSN-AS1 GSN antisense RNA 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXB5 homeobox B5
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGLJ3 immunoglobulin lambda joining 3
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIDINS220 kinase D-interacting substrate, 220kDa
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
KLF2 Kruppel-like factor 2
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT2 keratin 2, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LTBP2 latent transforming growth factor beta binding protein 2
MAN1C1 mannosidase, alpha, class 1C, member 1
MAOA monoamine oxidase A
MIER2 mesoderm induction early response 1, family member 2
MLNR motilin receptor
MMP13 matrix metallopeptidase 13
MPZ myelin protein zero
MXRA8 matrix-remodelling associated 8
N4BP2L1 NEDD4 binding protein 2-like 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHF20L1 PHD finger protein 20-like 1
PIPOX pipecolic acid oxidase
PLAGL1 pleiomorphic adenoma gene-like 1
PLXNA2 plexin A2
POU1F1 POU class 1 homeobox 1
PSCA prostate stem cell antigen
PTAFR platelet-activating factor receptor
RAD52 RAD52 homolog (S. cerevisiae)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASIP1 Ras interacting protein 1
RHOB ras homolog family member B
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SC5D sterol-C5-desaturase
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SFTPB surfactant protein B
SFXN3 sideroflexin 3
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPRR3 small proline-rich protein 3
STK38 serine/threonine kinase 38
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBXA2R thromboxane A2 receptor
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VPRBP Vpr (HIV-1) binding protein
WNT16 wingless-type MMTV integration site family, member 16
WSCD1 WSC domain containing 1
XAF1 XIAP associated factor 1
XYLB xylulokinase homolog (H. influenzae)
ZC3H13 zinc finger CCCH-type containing 13
ZFP64 ZFP64 zinc finger protein
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ATAD5 ATPase family, AAA domain containing 5
ATHL1 ATH1, acid trehalase-like 1 (yeast)
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAG4 BCL2-associated athanogene 4
BGLAP bone gamma-carboxyglutamate (gla) protein
BTF3P12 basic transcription factor 3 pseudogene 12
C19ORF73 chromosome 19 open reading frame 73
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAPRIN2 caprin family member 2
CCDC88C coiled-coil domain containing 88C
CCNK cyclin K
CD302 CD302 molecule
CD82 CD82 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDKN2AIP CDKN2A interacting protein
CENPO centromere protein O
CHKB choline kinase beta
CNR2 cannabinoid receptor 2 (macrophage)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DGAT1 diacylglycerol O-acyltransferase 1
DTX2 deltex 2, E3 ubiquitin ligase
DUSP13 dual specificity phosphatase 13
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EML4 echinoderm microtubule associated protein like 4
FADS2 fatty acid desaturase 2
FAM131A family with sequence similarity 131, member A
FAM189A2 family with sequence similarity 189, member A2
FOXN2 forkhead box N2
FRS2 fibroblast growth factor receptor substrate 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GDAP1 ganglioside induced differentiation associated protein 1
GMPR guanosine monophosphate reductase
GPATCH2L G patch domain containing 2-like
H1F0 H1 histone family, member 0
HDAC7 histone deacetylase 7
HIST1H2BJ histone cluster 1, H2bj
HIST1H4A histone cluster 1, H4a
HOXB2 homeobox B2
HP1BP3 heterochromatin protein 1, binding protein 3
HPX hemopexin
IRF7 interferon regulatory factor 7
KDM5C lysine (K)-specific demethylase 5C
KDM8 lysine (K)-specific demethylase 8
KIAA0319L KIAA0319-like
KIF13A kinesin family member 13A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT86 keratin 86, type II
LHX1 LIM homeobox 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP1S microtubule-associated protein 1S
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK10 mitogen-activated protein kinase 10
MEFV Mediterranean fever
MFAP2 microfibrillar-associated protein 2
MTERF4 mitochondrial transcription termination factor 4
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCSTN nicastrin
NPM3 nucleophosmin/nucleoplasmin 3
OLFML2A olfactomedin-like 2A
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PCDHA6 protocadherin alpha 6
PCDHB13 protocadherin beta 13
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLM polymerase (DNA directed), mu
POM121 POM121 transmembrane nucleoporin
PRODH proline dehydrogenase (oxidase) 1
QPCTL glutaminyl-peptide cyclotransferase-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS20 regulator of G-protein signaling 20
RHOBTB2 Rho-related BTB domain containing 2
ROM1 retinal outer segment membrane protein 1
RPL10L ribosomal protein L10-like
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SFT2D2 SFT2 domain containing 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SPINK5 serine peptidase inhibitor, Kazal type 5
THRAP3 thyroid hormone receptor associated protein 3
TMC5 transmembrane channel-like 5
TMEM120B transmembrane protein 120B
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
WDR78 WD repeat domain 78
ZNF211 zinc finger protein 211
ZNF227 zinc finger protein 227
ZNF230 zinc finger protein 230
ZNF37BP zinc finger protein 37B, pseudogene
ZNF551 zinc finger protein 551
ZNF573 zinc finger protein 573
ZSCAN26 zinc finger and SCAN domain containing 26