fluspirilene-6662 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the fluspirilene-6662 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
ADAM22 ADAM metallopeptidase domain 22
AGFG2 ArfGAP with FG repeats 2
AK2 adenylate kinase 2
ANGPTL2 angiopoietin-like 2
ARPIN actin-related protein 2/3 complex inhibitor
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
AURKC aurora kinase C
BLK BLK proto-oncogene, Src family tyrosine kinase
BMP1 bone morphogenetic protein 1
BUD31 BUD31 homolog (S. cerevisiae)
C17ORF59 chromosome 17 open reading frame 59
C6ORF10 chromosome 6 open reading frame 10
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDK13 cyclin-dependent kinase 13
CFLAR CASP8 and FADD-like apoptosis regulator
CNR2 cannabinoid receptor 2 (macrophage)
COMT catechol-O-methyltransferase
CRTC1 CREB regulated transcription coactivator 1
CYBRD1 cytochrome b reductase 1
DBF4B DBF4 zinc finger B
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DUSP2 dual specificity phosphatase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ETV1 ets variant 1
FLOT1 flotillin 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GIPR gastric inhibitory polypeptide receptor
GJA8 gap junction protein, alpha 8, 50kDa
GJB5 gap junction protein, beta 5, 31.1kDa
GLB1L2 galactosidase, beta 1-like 2
GPATCH4 G patch domain containing 4
GPR85 G protein-coupled receptor 85
GPX3 glutathione peroxidase 3
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HEMK1 HemK methyltransferase family member 1
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
ICAM1 intercellular adhesion molecule 1
ICAM5 intercellular adhesion molecule 5, telencephalin
ICOSLG inducible T-cell co-stimulator ligand
IFNA16 interferon, alpha 16
IKZF2 IKAROS family zinc finger 2 (Helios)
IL16 interleukin 16
IL2RG interleukin 2 receptor, gamma
INSIG1 insulin induced gene 1
ITGB6 integrin, beta 6
JAK3 Janus kinase 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KRTAP9-9 keratin associated protein 9-9
LINC00260 long intergenic non-protein coding RNA 260
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPK11 mitogen-activated protein kinase 11
MCF2L MCF.2 cell line derived transforming sequence-like
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MYO9B myosin IXB
NCAM1 neural cell adhesion molecule 1
NEO1 neogenin 1
NNMT nicotinamide N-methyltransferase
NPR2 natriuretic peptide receptor 2
NTM neurotrimin
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PDCD6 programmed cell death 6
PDE8B phosphodiesterase 8B
PHF7 PHD finger protein 7
PLEKHO1 pleckstrin homology domain containing, family O member 1
PTAFR platelet-activating factor receptor
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF126P1 ring finger protein 126 pseudogene 1
RRAGD Ras-related GTP binding D
RUFY3 RUN and FYVE domain containing 3
RUNX1 runt-related transcription factor 1
SARM1 sterile alpha and TIR motif containing 1
SCAND2P SCAN domain containing 2 pseudogene
SCARB1 scavenger receptor class B, member 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACC1 transforming, acidic coiled-coil containing protein 1
TCP11L1 t-complex 11, testis-specific-like 1
TGFA transforming growth factor, alpha
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
VAC14 Vac14 homolog (S. cerevisiae)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF334 zinc finger protein 334
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA2P1 annexin A2 pseudogene 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATF7IP2 activating transcription factor 7 interacting protein 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BOLA1 bolA family member 1
C14ORF93 chromosome 14 open reading frame 93
C17ORF70 chromosome 17 open reading frame 70
C1ORF105 chromosome 1 open reading frame 105
CCDC132 coiled-coil domain containing 132
CD82 CD82 molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CNGB3 cyclic nucleotide gated channel beta 3
CREB5 cAMP responsive element binding protein 5
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOCK1 dedicator of cytokinesis 1
DSPP dentin sialophosphoprotein
EDAR ectodysplasin A receptor
EHD3 EH-domain containing 3
FAM86C1 family with sequence similarity 86, member C1
FGF23 fibroblast growth factor 23
FMO4 flavin containing monooxygenase 4
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GEMIN8 gem (nuclear organelle) associated protein 8
GLS2 glutaminase 2 (liver, mitochondrial)
HAMP hepcidin antimicrobial peptide
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HIST1H2BI histone cluster 1, H2bi
HOMER2 homer scaffolding protein 2
HOXA1 homeobox A1
ITGB7 integrin, beta 7
KRT4 keratin 4, type II
LOC257152 uncharacterized LOC257152
LRP5L low density lipoprotein receptor-related protein 5-like
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGEF1 melanoma antigen family F1
MAGEH1 melanoma antigen family H1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGP matrix Gla protein
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL44 mitochondrial ribosomal protein L44
MTMR6 myotubularin related protein 6
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NID2 nidogen 2 (osteonidogen)
NKX3-2 NK3 homeobox 2
NLGN1 neuroligin 1
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NYNRIN NYN domain and retroviral integrase containing
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PICK1 protein interacting with PRKCA 1
PIP prolactin-induced protein
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLD2 phospholipase D2
PRSS53 protease, serine, 53
PTK6 protein tyrosine kinase 6
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
SAYSD1 SAYSVFN motif domain containing 1
SCEL sciellin
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIRT6 sirtuin 6
SIX3 SIX homeobox 3
SKI SKI proto-oncogene
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC35F6 solute carrier family 35, member F6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SPTBN2 spectrin, beta, non-erythrocytic 2
STARD5 StAR-related lipid transfer (START) domain containing 5
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TADA2A transcriptional adaptor 2A
TAGLN transgelin
TENM1 teneurin transmembrane protein 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TMEM180 transmembrane protein 180
TRAF2 TNF receptor-associated factor 2
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
TUBA4B tubulin, alpha 4b
VWA1 von Willebrand factor A domain containing 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB6 zinc finger and BTB domain containing 6
ZC4H2 zinc finger, C4H2 domain containing
ZNF141 zinc finger protein 141
ZNF623 zinc finger protein 623
ZNF675 zinc finger protein 675
ZNF76 zinc finger protein 76
ZNF816 zinc finger protein 816
ZW10 zw10 kinetochore protein