flurbiprofen-4674 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the flurbiprofen-4674 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRA1A adrenoceptor alpha 1A
AKAP5 A kinase (PRKA) anchor protein 5
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARTN artemin
ATAD5 ATPase family, AAA domain containing 5
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BBC3 BCL2 binding component 3
C10ORF10 chromosome 10 open reading frame 10
C18ORF25 chromosome 18 open reading frame 25
C21ORF2 chromosome 21 open reading frame 2
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CACYBP calcyclin binding protein
CADM4 cell adhesion molecule 4
CD6 CD6 molecule
CD72 CD72 molecule
CD96 CD96 molecule
CDH5 cadherin 5, type 2 (vascular endothelium)
CDH8 cadherin 8, type 2
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHAT choline O-acetyltransferase
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CNGB3 cyclic nucleotide gated channel beta 3
COL14A1 collagen, type XIV, alpha 1
CPA2 carboxypeptidase A2 (pancreatic)
CST4 cystatin S
CXCR4 chemokine (C-X-C motif) receptor 4
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DGKE diacylglycerol kinase, epsilon 64kDa
E2F4 E2F transcription factor 4, p107/p130-binding
FER1L4 fer-1-like family member 4, pseudogene (functional)
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GJC2 gap junction protein, gamma 2, 47kDa
GOLGA2 golgin A2
HOXD9 homeobox D9
HSPG2 heparan sulfate proteoglycan 2
HUS1 HUS1 checkpoint homolog (S. pombe)
IL11 interleukin 11
IL6ST interleukin 6 signal transducer
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLF4 Kruppel-like factor 4 (gut)
KRT17 keratin 17, type I
KRTAP9-9 keratin associated protein 9-9
LEF1 lymphoid enhancer-binding factor 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MORN1 MORN repeat containing 1
MTAP methylthioadenosine phosphorylase
MXD4 MAX dimerization protein 4
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NCLN nicalin
NEK1 NIMA-related kinase 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ONECUT2 one cut homeobox 2
PARP8 poly (ADP-ribose) polymerase family, member 8
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCDH1 protocadherin 1
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PKD2L2 polycystic kidney disease 2-like 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRDM2 PR domain containing 2, with ZNF domain
PROX1 prospero homeobox 1
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTBP3 polypyrimidine tract binding protein 3
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PVR poliovirus receptor
RANBP1 RAN binding protein 1
RFXAP regulatory factor X-associated protein
ROR2 receptor tyrosine kinase-like orphan receptor 2
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD3 SMAD family member 3
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOSTDC1 sclerostin domain containing 1
SOX30 SRY (sex determining region Y)-box 30
SP110 SP110 nuclear body protein
SPTBN5 spectrin, beta, non-erythrocytic 5
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSTR2 somatostatin receptor 2
STX7 syntaxin 7
SUGP1 SURP and G patch domain containing 1
SVIL supervillin
TET3 tet methylcytosine dioxygenase 3
TIMP4 TIMP metallopeptidase inhibitor 4
TMPRSS4 transmembrane protease, serine 4
TPPP tubulin polymerization promoting protein
TRIM15 tripartite motif containing 15
TRIM29 tripartite motif containing 29
TXNRD3 thioredoxin reductase 3
TYMS thymidylate synthetase
VAX2 ventral anterior homeobox 2
WSB1 WD repeat and SOCS box containing 1
ZNF37BP zinc finger protein 37B, pseudogene
ZNF391 zinc finger protein 391

decreased expression

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADGRG2 adhesion G protein-coupled receptor G2
ANOS1 anosmin 1
ANP32A-IT1 ANP32A intronic transcript 1
APH1B APH1B gamma secretase subunit
ARL14 ADP-ribosylation factor-like 14
C14ORF105 chromosome 14 open reading frame 105
C1RL complement component 1, r subcomponent-like
CASP5 caspase 5, apoptosis-related cysteine peptidase
CD101 CD101 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CEL carboxyl ester lipase
CFAP45 cilia and flagella associated protein 45
CGREF1 cell growth regulator with EF-hand domain 1
CLCN6 chloride channel, voltage-sensitive 6
CNN1 calponin 1, basic, smooth muscle
CPNE7 copine VII
CPZ carboxypeptidase Z
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSF cathepsin F
CYSLTR1 cysteinyl leukotriene receptor 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DSPP dentin sialophosphoprotein
EDC4 enhancer of mRNA decapping 4
ELOVL4 ELOVL fatty acid elongase 4
EYA4 EYA transcriptional coactivator and phosphatase 4
FKBP10 FK506 binding protein 10, 65 kDa
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GALT galactose-1-phosphate uridylyltransferase
GPR27 G protein-coupled receptor 27
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
H2AFJ H2A histone family, member J
HDAC7 histone deacetylase 7
HIST1H2AJ histone cluster 1, H2aj
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HOXA4 homeobox A4
HOXA7 homeobox A7
IFT140 intraflagellar transport 140
IL17RB interleukin 17 receptor B
IL20RA interleukin 20 receptor, alpha
ING4 inhibitor of growth family, member 4
KDM8 lysine (K)-specific demethylase 8
KIAA0895 KIAA0895
KLHL25 kelch-like family member 25
KRT33A keratin 33A, type I
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC730101 uncharacterized LOC730101
LRP3 low density lipoprotein receptor-related protein 3
LRRK1 leucine-rich repeat kinase 1
LYPLA2P1 lysophospholipase II pseudogene 1
MAGEF1 melanoma antigen family F1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL41 mitochondrial ribosomal protein L41
MUC3B mucin 3B, cell surface associated
MYOZ3 myozenin 3
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NME5 NME/NM23 family member 5
NOL10 nucleolar protein 10
NOL12 nucleolar protein 12
NRTN neurturin
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PACS1 phosphofurin acidic cluster sorting protein 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PCDH12 protocadherin 12
PEG3 paternally expressed 3
PELP1 proline, glutamate and leucine rich protein 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
POLH polymerase (DNA directed), eta
POMT2 protein-O-mannosyltransferase 2
PRB3 proline-rich protein BstNI subfamily 3
R3HCC1L R3H domain and coiled-coil containing 1-like
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RPP25 ribonuclease P/MRP 25kDa subunit
RWDD2A RWD domain containing 2A
SIRT2 sirtuin 2
SKI SKI proto-oncogene
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOBP sine oculis binding protein homolog (Drosophila)
SPIDR scaffolding protein involved in DNA repair
SPINK1 serine peptidase inhibitor, Kazal type 1
STAB2 stabilin 2
STAG3 stromal antigen 3
SYNGR3 synaptogyrin 3
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF350 zinc finger protein 350
ZNF428 zinc finger protein 428
ZNF446 zinc finger protein 446
ZNF623 zinc finger protein 623
ZNF768 zinc finger protein 768
ZNF804A zinc finger protein 804A