fluphenazine-494 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the fluphenazine-494 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM20 ADAM metallopeptidase domain 20
AFF1 AF4/FMR2 family, member 1
AFM afamin
AMT aminomethyltransferase
ANAPC2 anaphase promoting complex subunit 2
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARR3 arrestin 3, retinal (X-arrestin)
ASCL1 achaete-scute family bHLH transcription factor 1
ASRGL1 asparaginase like 1
BICD1 bicaudal D homolog 1 (Drosophila)
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CACFD1 calcium channel flower domain containing 1
CCDC64 coiled-coil domain containing 64
CD22 CD22 molecule
CD6 CD6 molecule
CETN1 centrin, EF-hand protein, 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CISH cytokine inducible SH2-containing protein
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
DCTN2 dynactin 2 (p50)
DLAT dihydrolipoamide S-acetyltransferase
EPX eosinophil peroxidase
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC7 exocyst complex component 7
FBXO11 F-box protein 11
FHL3 four and a half LIM domains 3
FUT2 fucosyltransferase 2 (secretor status included)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS8 growth arrest-specific 8
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGF1 insulin-like growth factor 1 (somatomedin C)
INSIG1 insulin induced gene 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB5 integrin, beta 5
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LHX2 LIM homeobox 2
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MED18 mediator complex subunit 18
MIIP migration and invasion inhibitory protein
MMP25 matrix metallopeptidase 25
MRPS12 mitochondrial ribosomal protein S12
MSMO1 methylsterol monooxygenase 1
MST1 macrophage stimulating 1
MST1R macrophage stimulating 1 receptor
MXD4 MAX dimerization protein 4
MYOZ3 myozenin 3
NCKAP1L NCK-associated protein 1-like
NCR2 natural cytotoxicity triggering receptor 2
NDRG2 NDRG family member 2
NPTX1 neuronal pentraxin I
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NXPH3 neurexophilin 3
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALM paralemmin
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEX10 peroxisomal biogenesis factor 10
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PNPLA3 patatin-like phospholipase domain containing 3
PQLC2 PQ loop repeat containing 2
PVRIG poliovirus receptor related immunoglobulin domain containing
RASIP1 Ras interacting protein 1
RECQL5 RecQ protein-like 5
RRP1B ribosomal RNA processing 1B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFXN3 sideroflexin 3
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX21 SRY (sex determining region Y)-box 21
SPDEF SAM pointed domain containing ETS transcription factor
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TCF3 transcription factor 3
TGM5 transglutaminase 5
TLE2 transducin-like enhancer of split 2
TMEM161A transmembrane protein 161A
TMEM63A transmembrane protein 63A
TMPRSS11D transmembrane protease, serine 11D
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNIP1 TNFAIP3 interacting protein 1
TRIM14 tripartite motif containing 14
TRPV5 transient receptor potential cation channel, subfamily V, member 5
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
ZC3H12A zinc finger CCCH-type containing 12A
ZCCHC4 zinc finger, CCHC domain containing 4
ZCCHC6 zinc finger, CCHC domain containing 6
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ADAMTSL4 ADAMTS-like 4
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
AKIP1 A kinase (PRKA) interacting protein 1
ALPK1 alpha-kinase 1
ASTE1 asteroid homolog 1 (Drosophila)
BARD1 BRCA1 associated RING domain 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C22ORF29 chromosome 22 open reading frame 29
C6 complement component 6
C7ORF43 chromosome 7 open reading frame 43
CBY1 chibby homolog 1 (Drosophila)
CCDC7 coiled-coil domain containing 7
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD83 CD83 molecule
CD96 CD96 molecule
CDC37 cell division cycle 37
CDCA8 cell division cycle associated 8
CDK20 cyclin-dependent kinase 20
CLCN2 chloride channel, voltage-sensitive 2
CLDN17 claudin 17
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRBN cereblon
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CST4 cystatin S
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYB5R3 cytochrome b5 reductase 3
DGKD diacylglycerol kinase, delta 130kDa
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
ECI1 enoyl-CoA delta isomerase 1
EPHA4 EPH receptor A4
FAM188A family with sequence similarity 188, member A
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FSHB follicle stimulating hormone, beta polypeptide
GAMT guanidinoacetate N-methyltransferase
GLRA2 glycine receptor, alpha 2
GPA33 glycoprotein A33 (transmembrane)
GUCA2A guanylate cyclase activator 2A (guanylin)
HELLS helicase, lymphoid-specific
HMGB3P1 high mobility group box 3 pseudogene 1
HPGDS hematopoietic prostaglandin D synthase
HPSE heparanase
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
IL15RA interleukin 15 receptor, alpha
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4
KIF20B kinesin family member 20B
KIFC1 kinesin family member C1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LAMA1 laminin, alpha 1
LINC01558 long intergenic non-protein coding RNA 1558
LMAN2L lectin, mannose-binding 2-like
LMBR1L limb development membrane protein 1-like
LRRC20 leucine rich repeat containing 20
LRRTM2 leucine rich repeat transmembrane neuronal 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAB21L1 mab-21-like 1 (C. elegans)
MCM10 minichromosome maintenance complex component 10
MSRB1 methionine sulfoxide reductase B1
MT2A metallothionein 2A
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NELL2 NEL-like 2 (chicken)
NOTCH4 notch 4
NUBP2 nucleotide binding protein 2
OGFRL1 opioid growth factor receptor-like 1
PFAS phosphoribosylformylglycinamidine synthase
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLA2G10 phospholipase A2, group X
PLD3 phospholipase D family, member 3
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PLXNB3 plexin B3
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPP1R26 protein phosphatase 1, regulatory subunit 26
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRAMEF11 PRAME family member 11
PRKCZ protein kinase C, zeta
PRPF3 pre-mRNA processing factor 3
PRPH2 peripherin 2 (retinal degeneration, slow)
RAB3A RAB3A, member RAS oncogene family
RASAL1 RAS protein activator like 1 (GAP1 like)
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RNF141 ring finger protein 141
RNF220 ring finger protein 220
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RUSC1 RUN and SH3 domain containing 1
SELL selectin L
SHPK sedoheptulokinase
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMYD5 SMYD family member 5
TMPRSS6 transmembrane protease, serine 6
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TP53BP1 tumor protein p53 binding protein 1
TTC27 tetratricopeptide repeat domain 27
TTC4 tetratricopeptide repeat domain 4
TYK2 tyrosine kinase 2
UBE2O ubiquitin-conjugating enzyme E2O
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
ZNF140 zinc finger protein 140