flunarizine-7252 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the flunarizine-7252 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADRBK1 adrenergic, beta, receptor kinase 1
AKR1C1 aldo-keto reductase family 1, member C1
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ARID5A AT rich interactive domain 5A (MRF1-like)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATXN3 ataxin 3
B9D1 B9 protein domain 1
C10ORF88 chromosome 10 open reading frame 88
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHM choroideremia (Rab escort protein 1)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLEC2B C-type lectin domain family 2, member B
DHODH dihydroorotate dehydrogenase (quinone)
DUSP10 dual specificity phosphatase 10
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGF epidermal growth factor
EPHB2 EPH receptor B2
FAM131B family with sequence similarity 131, member B
FAM173A family with sequence similarity 173, member A
FAM69A family with sequence similarity 69, member A
FLOT2 flotillin 2
FLT1 fms-related tyrosine kinase 1
FXR2 fragile X mental retardation, autosomal homolog 2
GALK2 galactokinase 2
GON4L gon-4-like (C. elegans)
GPATCH2L G patch domain containing 2-like
GSAP gamma-secretase activating protein
GTPBP1 GTP binding protein 1
HOXB2 homeobox B2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ITM2B integral membrane protein 2B
LDB1 LIM domain binding 1
LRRK1 leucine-rich repeat kinase 1
LYPD1 LY6/PLAUR domain containing 1
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED13L mediator complex subunit 13-like
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
NNT nicotinamide nucleotide transhydrogenase
NRXN3 neurexin 3
OASL 2'-5'-oligoadenylate synthetase-like
PEX7 peroxisomal biogenesis factor 7
PICALM phosphatidylinositol binding clathrin assembly protein
PIDD1 p53-induced death domain protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKD1 polycystic kidney disease 1 (autosomal dominant)
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRMT2 protein arginine methyltransferase 2
QKI QKI, KH domain containing, RNA binding
RAB2A RAB2A, member RAS oncogene family
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS4 regulator of G-protein signaling 4
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RPAIN RPA interacting protein
S100A3 S100 calcium binding protein A3
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNPH syntaphilin
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STS steroid sulfatase (microsomal), isozyme S
STX6 syntaxin 6
TAPBP TAP binding protein (tapasin)
TCTN1 tectonic family member 1
TEX40 testis expressed 40
TFR2 transferrin receptor 2
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TJAP1 tight junction associated protein 1 (peripheral)
TK2 thymidine kinase 2, mitochondrial
TLK1 tousled-like kinase 1
TMEM242 transmembrane protein 242
TMEM8B transmembrane protein 8B
TOR1AIP1 torsin A interacting protein 1
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSFM Ts translation elongation factor, mitochondrial
TUBG2 tubulin, gamma 2
ULBP2 UL16 binding protein 2
USP24 ubiquitin specific peptidase 24
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZBTB22 zinc finger and BTB domain containing 22
ZNF200 zinc finger protein 200
ZNF45 zinc finger protein 45

decreased expression

Symbol Name
ARMC6 armadillo repeat containing 6
ASS1 argininosuccinate synthase 1
B3GAT3 beta-1,3-glucuronyltransferase 3
BCAS4 breast carcinoma amplified sequence 4
BRD1 bromodomain containing 1
C16ORF59 chromosome 16 open reading frame 59
C1ORF112 chromosome 1 open reading frame 112
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHKB choline kinase beta
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLCF1 cardiotrophin-like cytokine factor 1
CLDN3 claudin 3
CLSPN claspin
CRIP1 cysteine-rich protein 1 (intestinal)
CTAGE9 CTAGE family, member 9
CUL9 cullin 9
DGKZ diacylglycerol kinase, zeta
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EDC3 enhancer of mRNA decapping 3
EFNA1 ephrin-A1
EN1 engrailed homeobox 1
ETV4 ets variant 4
EXOC3 exocyst complex component 3
FAM188A family with sequence similarity 188, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FKBPL FK506 binding protein like
FLRT3 fibronectin leucine rich transmembrane protein 3
FPGS folylpolyglutamate synthase
FSD1 fibronectin type III and SPRY domain containing 1
GAB2 GRB2-associated binding protein 2
GCA grancalcin, EF-hand calcium binding protein
GLCE glucuronic acid epimerase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AJ histone cluster 1, H2aj
HMHA1 histocompatibility (minor) HA-1
HOXC8 homeobox C8
ICK intestinal cell (MAK-like) kinase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KLF11 Kruppel-like factor 11
KRI1 KRI1 homolog (S. cerevisiae)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LMBR1L limb development membrane protein 1-like
LRP5 low density lipoprotein receptor-related protein 5
MACROD1 MACRO domain containing 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MEIS1 Meis homeobox 1
METTL2B methyltransferase like 2B
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPC1 mitochondrial pyruvate carrier 1
MRPL2 mitochondrial ribosomal protein L2
MTG1 mitochondrial ribosome-associated GTPase 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYLK myosin light chain kinase
NCAPH non-SMC condensin I complex, subunit H
NDE1 nudE neurodevelopment protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
ODF2 outer dense fiber of sperm tails 2
PAQR4 progestin and adipoQ receptor family member IV
PARD6A par-6 family cell polarity regulator alpha
PEX26 peroxisomal biogenesis factor 26
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
POLH polymerase (DNA directed), eta
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RNF121 ring finger protein 121
RNF126P1 ring finger protein 126 pseudogene 1
RNF25 ring finger protein 25
RPAP2 RNA polymerase II associated protein 2
RPGR retinitis pigmentosa GTPase regulator
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC12A8 solute carrier family 12, member 8
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SPATA7 spermatogenesis associated 7
SREBF1 sterol regulatory element binding transcription factor 1
SYTL2 synaptotagmin-like 2
TGFBR3 transforming growth factor, beta receptor III
THAP1 THAP domain containing, apoptosis associated protein 1
TIGD6 tigger transposable element derived 6
TMEM62 transmembrane protein 62
TPST2 tyrosylprotein sulfotransferase 2
TTC26 tetratricopeptide repeat domain 26
UBQLN4 ubiquilin 4
USP6NL USP6 N-terminal like
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB48 zinc finger and BTB domain containing 48
ZNF107 zinc finger protein 107
ZNF180 zinc finger protein 180
ZNF415 zinc finger protein 415
ZNF574 zinc finger protein 574