flufenamic acid-2267 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the flufenamic acid-2267 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACACB acetyl-CoA carboxylase beta
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRA2 adhesion G protein-coupled receptor A2
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP3 aquaporin 3 (Gill blood group)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATN1 atrophin 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BDKRB2 bradykinin receptor B2
C5ORF42 chromosome 5 open reading frame 42
CALCR calcitonin receptor
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CARD10 caspase recruitment domain family, member 10
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFAP70 cilia and flagella associated protein 70
CFHR2 complement factor H-related 2
CFLAR CASP8 and FADD-like apoptosis regulator
CNTN5 contactin 5
COMT catechol-O-methyltransferase
CT62 cancer/testis antigen 62
CTSO cathepsin O
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DICER1 dicer 1, ribonuclease type III
DOCK10 dedicator of cytokinesis 10
EFNB3 ephrin-B3
EHD2 EH-domain containing 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR1 fibroblast growth factor receptor 1
GM2A GM2 ganglioside activator
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR137 G protein-coupled receptor 137
HEXIM1 hexamethylene bis-acetamide inducible 1
HFE hemochromatosis
HIST1H3A histone cluster 1, H3a
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL17RC interleukin 17 receptor C
IQSEC2 IQ motif and Sec7 domain 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF24 kinesin family member 24
KIF25 kinesin family member 25
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KMT2A lysine (K)-specific methyltransferase 2A
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTBP4 latent transforming growth factor beta binding protein 4
LYZL6 lysozyme-like 6
MAPK8 mitogen-activated protein kinase 8
MED18 mediator complex subunit 18
MEF2C myocyte enhancer factor 2C
MEF2D myocyte enhancer factor 2D
METTL7A methyltransferase like 7A
MID1 midline 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NEK1 NIMA-related kinase 1
NF1 neurofibromin 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRL neural retina leucine zipper
NUDCD3 NudC domain containing 3
ONECUT2 one cut homeobox 2
PDE10A phosphodiesterase 10A
POFUT1 protein O-fucosyltransferase 1
POPDC3 popeye domain containing 3
PPARD peroxisome proliferator-activated receptor delta
PRG3 proteoglycan 3
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM12B RNA binding motif protein 12B
RBM17 RNA binding motif protein 17
RHEB Ras homolog enriched in brain
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RND2 Rho family GTPase 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
SFTPB surfactant protein B
SIPA1L3 signal-induced proliferation-associated 1 like 3
SNRK SNF related kinase
SOX10 SRY (sex determining region Y)-box 10
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYNDIG1 synapse differentiation inducing 1
TBX5 T-box 5
TJAP1 tight junction associated protein 1 (peripheral)
TMCC2 transmembrane and coiled-coil domain family 2
TMEM63A transmembrane protein 63A
TPMT thiopurine S-methyltransferase
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TUBA3C tubulin, alpha 3c
UBA7 ubiquitin-like modifier activating enzyme 7
VPS13B vacuolar protein sorting 13 homolog B (yeast)

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD17B abhydrolase domain containing 17B
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BCAS1 breast carcinoma amplified sequence 1
BFSP1 beaded filament structural protein 1, filensin
C7ORF43 chromosome 7 open reading frame 43
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC121 coiled-coil domain containing 121
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLSPN claspin
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EGFL7 EGF-like-domain, multiple 7
ERCC6 excision repair cross-complementation group 6
ETNK2 ethanolamine kinase 2
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FAM186A family with sequence similarity 186, member A
FBXL7 F-box and leucine-rich repeat protein 7
FKBP10 FK506 binding protein 10, 65 kDa
FOXI1 forkhead box I1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX2 glutathione peroxidase 2
GSTM2 glutathione S-transferase mu 2 (muscle)
HIST1H2AI histone cluster 1, H2ai
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BO histone cluster 1, H2bo
HPN hepsin
IDI2-AS1 IDI2 antisense RNA 1
INPP1 inositol polyphosphate-1-phosphatase
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPKB inositol-trisphosphate 3-kinase B
KCNK12 potassium channel, two pore domain subfamily K, member 12
KLHDC8A kelch domain containing 8A
KRT24 keratin 24, type I
LAMP3 lysosomal-associated membrane protein 3
LAX1 lymphocyte transmembrane adaptor 1
LIF leukemia inhibitory factor
LINC00597 long intergenic non-protein coding RNA 597
LRP5 low density lipoprotein receptor-related protein 5
MBOAT2 membrane bound O-acyltransferase domain containing 2
MCC mutated in colorectal cancers
MEFV Mediterranean fever
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL44 mitochondrial ribosomal protein L44
MT1H metallothionein 1H
NOD1 nucleotide-binding oligomerization domain containing 1
NPM3 nucleophosmin/nucleoplasmin 3
NRSN2 neurensin 2
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PLA2G15 phospholipase A2, group XV
PLCD1 phospholipase C, delta 1
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RABL3 RAB, member of RAS oncogene family-like 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFPL1S RFPL1 antisense RNA 1
RIN2 Ras and Rab interactor 2
S100A9 S100 calcium binding protein A9
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SKI SKI proto-oncogene
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLPI secretory leukocyte peptidase inhibitor
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNTA1 syntrophin, alpha 1
STMN3 stathmin-like 3
SUN2 Sad1 and UNC84 domain containing 2
TBKBP1 TBK1 binding protein 1
TEAD3 TEA domain family member 3
TEX40 testis expressed 40
TFF2 trefoil factor 2
TLN1 talin 1
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TOM1 target of myb1 (chicken)
TPK1 thiamin pyrophosphokinase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UNC93B1 unc-93 homolog B1 (C. elegans)
VASH2 vasohibin 2
YY2 YY2 transcription factor
ZBTB22 zinc finger and BTB domain containing 22
ZBTB33 zinc finger and BTB domain containing 33
ZBTB44 zinc finger and BTB domain containing 44
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF10 zinc finger protein 10
ZNF428 zinc finger protein 428
ZNF442 zinc finger protein 442
ZNF747 zinc finger protein 747