flecainide-4318 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the flecainide-4318 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAM8 ADAM metallopeptidase domain 8
ADCY1 adenylate cyclase 1 (brain)
ADD2 adducin 2 (beta)
AKT2 v-akt murine thymoma viral oncogene homolog 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BCL2L1 BCL2-like 1
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
COL6A1 collagen, type VI, alpha 1
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CYTH4 cytohesin 4
DGKA diacylglycerol kinase, alpha 80kDa
DKFZP434C153 DKFZP434C153 protein
DLX2 distal-less homeobox 2
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DTNA dystrobrevin, alpha
EGFR epidermal growth factor receptor
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FBXO22 F-box protein 22
FGFR4 fibroblast growth factor receptor 4
FSCN3 fascin actin-bundling protein 3, testicular
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR137 G protein-coupled receptor 137
GSK3A glycogen synthase kinase 3 alpha
GSPT1 G1 to S phase transition 1
GTPBP1 GTP binding protein 1
HDAC11 histone deacetylase 11
HDAC6 histone deacetylase 6
HFE hemochromatosis
HPN hepsin
HRG histidine-rich glycoprotein
HSF1 heat shock transcription factor 1
IL32 interleukin 32
JAK3 Janus kinase 3
KIAA1109 KIAA1109
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KITLG KIT ligand
KMT2A lysine (K)-specific methyltransferase 2A
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMAN1 lectin, mannose-binding, 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MCL1 myeloid cell leukemia 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MFN2 mitofusin 2
MTCP1 mature T-cell proliferation 1
MTMR1 myotubularin related protein 1
NEK9 NIMA-related kinase 9
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR4A2 nuclear receptor subfamily 4, group A, member 2
PASK PAS domain containing serine/threonine kinase
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEX16 peroxisomal biogenesis factor 16
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLCL2 phospholipase C-like 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PSORS1C1 psoriasis susceptibility 1 candidate 1
RAB35 RAB35, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RARG retinoic acid receptor, gamma
RND1 Rho family GTPase 1
RNF122 ring finger protein 122
RNF43 ring finger protein 43
RUNX1 runt-related transcription factor 1
SAPCD1 suppressor APC domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SORT1 sortilin 1
SP1 Sp1 transcription factor
SPPL2B signal peptide peptidase like 2B
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPR signal recognition particle receptor (docking protein)
STC1 stanniocalcin 1
SYNJ1 synaptojanin 1
SYT2 synaptotagmin II
TACR1 tachykinin receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM206 transmembrane protein 206
TMEM259 transmembrane protein 259
TMOD1 tropomodulin 1
TMPRSS2 transmembrane protease, serine 2
TONSL tonsoku-like, DNA repair protein
TUBGCP2 tubulin, gamma complex associated protein 2
U2AF2 U2 small nuclear RNA auxiliary factor 2
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
WT1 Wilms tumor 1
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ADAM23 ADAM metallopeptidase domain 23
ADAP2 ArfGAP with dual PH domains 2
AKAP5 A kinase (PRKA) anchor protein 5
ALPK1 alpha-kinase 1
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
ARMCX4 armadillo repeat containing, X-linked 4
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BEST2 bestrophin 2
C14ORF79 chromosome 14 open reading frame 79
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C1ORF54 chromosome 1 open reading frame 54
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAPN15 calpain 15
CCDC177 coiled-coil domain containing 177
CD53 CD53 molecule
CENPO centromere protein O
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCN5 chloride channel, voltage-sensitive 5
CLSPN claspin
CRY2 cryptochrome circadian clock 2
CUZD1 CUB and zona pellucida-like domains 1
CXORF21 chromosome X open reading frame 21
DBF4B DBF4 zinc finger B
DNM3 dynamin 3
EFNB1 ephrin-B1
ELP6 elongator acetyltransferase complex subunit 6
ERCC5 excision repair cross-complementation group 5
FGF23 fibroblast growth factor 23
FLT4 fms-related tyrosine kinase 4
GINS4 GINS complex subunit 4 (Sld5 homolog)
GLB1L galactosidase, beta 1-like
GLRA1 glycine receptor, alpha 1
GPR85 G protein-coupled receptor 85
GUSBP3 glucuronidase, beta pseudogene 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2BM histone cluster 1, H2bm
HOOK1 hook microtubule-tethering protein 1
HOXC11 homeobox C11
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IRAK4 interleukin-1 receptor-associated kinase 4
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KDM7A lysine (K)-specific demethylase 7A
KLHL25 kelch-like family member 25
KRT32 keratin 32, type I
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LIMD2 LIM domain containing 2
LRRC37A3 leucine rich repeat containing 37, member A3
LYRM9 LYR motif containing 9
MFSD11 major facilitator superfamily domain containing 11
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NTSR1 neurotensin receptor 1 (high affinity)
ORAI3 ORAI calcium release-activated calcium modulator 3
PCDHA5 protocadherin alpha 5
PENK proenkephalin
PLA2G1B phospholipase A2, group IB (pancreas)
POLL polymerase (DNA directed), lambda
POM121L2 POM121 transmembrane nucleoporin-like 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RNF39 ring finger protein 39
SCARA3 scavenger receptor class A, member 3
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC12A9 solute carrier family 12, member 9
SLC44A1 solute carrier family 44 (choline transporter), member 1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNGR4 synaptogyrin 4
TEP1 telomerase-associated protein 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM159 transmembrane protein 159
TMEM19 transmembrane protein 19
TMEM8B transmembrane protein 8B
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM16 tripartite motif containing 16
TSNAXIP1 translin-associated factor X interacting protein 1
TSPAN32 tetraspanin 32
TUBA4B tubulin, alpha 4b
UNKL unkempt family zinc finger-like
VEZT vezatin, adherens junctions transmembrane protein
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF160 zinc finger protein 160
ZNF219 zinc finger protein 219
ZNF264 zinc finger protein 264
ZNF280B zinc finger protein 280B
ZNF652 zinc finger protein 652
ZNF749 zinc finger protein 749