fetal alcohol syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction. (Human Disease Ontology, DOID_0050665)
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Genes

143 genes co-occuring with the disease fetal alcohol syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PFAS phosphoribosylformylglycinamidine synthase 2.32258
ACSS3 acyl-CoA synthetase short-chain family member 3 1.19273
RBP1 retinol binding protein 1, cellular 1.07446
ADNP activity-dependent neuroprotector homeobox 1.07068
NOX3 NADPH oxidase 3 1.06102
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.01554
L1CAM L1 cell adhesion molecule 0.993596
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.947019
ACSS1 acyl-CoA synthetase short-chain family member 1 0.931242
MSX2 msh homeobox 2 0.931242
SHH sonic hedgehog 0.929587
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.908965
TTC3 tetratricopeptide repeat domain 3 0.888029
VAX2 ventral anterior homeobox 2 0.871234
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.860999
ACER3 alkaline ceramidase 3 0.859362
SGMS2 sphingomyelin synthase 2 0.858543
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.84585
CUX2 cut-like homeobox 2 0.812642
RERE arginine-glutamic acid dipeptide (RE) repeats 0.804846
PVALB parvalbumin 0.793771
ADCY8 adenylate cyclase 8 (brain) 0.782707
IGF1 insulin-like growth factor 1 (somatomedin C) 0.766351
NOXA1 NADPH oxidase activator 1 0.765127
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.759008
CSH2 chorionic somatomammotropin hormone 2 0.737054
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.731786
VIP vasoactive intestinal peptide 0.723694
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.720865
NGF nerve growth factor (beta polypeptide) 0.716425
NOXO1 NADPH oxidase organizer 1 0.712796
DGCR2 DiGeorge syndrome critical region gene 2 0.701124
LHX6 LIM homeobox 6 0.699517
BDNF brain-derived neurotrophic factor 0.687091
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.685491
ADH6 alcohol dehydrogenase 6 (class V) 0.674713
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.654858
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.644981
RNF25 ring finger protein 25 0.642221
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.633563
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.625711
GGT1 gamma-glutamyltransferase 1 0.617094
CELF2 CUGBP, Elav-like family member 2 0.59874
FZD8 frizzled class receptor 8 0.587054
FGF2 fibroblast growth factor 2 (basic) 0.570329
RXRB retinoid X receptor, beta 0.564889
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.5645
ACSS2 acyl-CoA synthetase short-chain family member 2 0.549747
VANGL1 VANGL planar cell polarity protein 1 0.549359
LIM2 lens intrinsic membrane protein 2, 19kDa 0.548971
EGLN1 egl-9 family hypoxia-inducible factor 1 0.533475
VANGL2 VANGL planar cell polarity protein 2 0.523816
ALDOC aldolase C, fructose-bisphosphate 0.522659
NES nestin 0.521502
MALL mal, T-cell differentiation protein-like 0.516494
CHAT choline O-acetyltransferase 0.509959
BHLHE41 basic helix-loop-helix family, member e41 0.506507
PAX6 paired box 6 0.494266
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.490454
BPIFA1 BPI fold containing family A, member 1 0.477909
DYNLL1 dynein, light chain, LC8-type 1 0.474498
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.470332
IRS1 insulin receptor substrate 1 0.469197
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.468063
ERCC6L excision repair cross-complementation group 6-like 0.455978
INS insulin 0.449571
CALB2 calbindin 2 0.442418
FABP7 fatty acid binding protein 7, brain 0.438658
GPHN gephyrin 0.424765
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.424389
RHOA ras homolog family member A 0.414276
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.413153
CRAT carnitine O-acetyltransferase 0.402692
SOD2 superoxide dismutase 2, mitochondrial 0.399334
TF transferrin 0.396353
PLD2 phospholipase D2 0.396353
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.395608
GFAP glial fibrillary acidic protein 0.390397
REST RE1-silencing transcription factor 0.372958
PSG9 pregnancy specific beta-1-glycoprotein 9 0.365932
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.365193
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.345675
BAX BCL2-associated X protein 0.340906
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.337975
RCAN1 regulator of calcineurin 1 0.336144
BAD BCL2-associated agonist of cell death 0.330295
CELF1 CUGBP, Elav-like family member 1 0.328105
GLUL glutamate-ammonia ligase 0.319726
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.310652
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.308842
LCT lactase 0.306672
CALB1 calbindin 1, 28kDa 0.305948
FOS FBJ murine osteosarcoma viral oncogene homolog 0.304142
ADGRV1 adhesion G protein-coupled receptor V1 0.299092
HOXA1 homeobox A1 0.298371
PDLIM1 PDZ and LIM domain 1 0.297651
TBX5 T-box 5 0.296571
EBF1 early B-cell factor 1 0.287952
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.284371
CAT catalase 0.28151
NANOG Nanog homeobox 0.278654
ASPH aspartate beta-hydroxylase 0.274376
OCRL oculocerebrorenal syndrome of Lowe 0.264077
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.263722
FADS2 fatty acid desaturase 2 0.260538
BCL2 B-cell CLL/lymphoma 2 0.257005
RARB retinoic acid receptor, beta 0.251015
LARGE like-glycosyltransferase 0.24996
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.238054
NPS neuropeptide S 0.228679
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.222136
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.219398
CDC73 cell division cycle 73 0.215992
SYN1 synapsin I 0.212271
MAP7 microtubule-associated protein 7 0.212271
MECP2 methyl CpG binding protein 2 0.210925
MAP2 microtubule-associated protein 2 0.201962
ALPPL2 alkaline phosphatase, placental-like 2 0.197742
MBP myelin basic protein 0.19742
ALPP alkaline phosphatase, placental 0.19742
ALPL alkaline phosphatase, liver/bone/kidney 0.196779
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.188326
PHYH phytanoyl-CoA 2-hydroxylase 0.188022
OLIG2 oligodendrocyte lineage transcription factor 2 0.18472
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.178126
FGFR1 fibroblast growth factor receptor 1 0.176215
DRD2 dopamine receptor D2 0.175411
ADCY2 adenylate cyclase 2 (brain) 0.174617
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.173571
DUOX1 dual oxidase 1 0.172038
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.171535
INSR insulin receptor 0.170544
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.170054
PPARD peroxisome proliferator-activated receptor delta 0.166319
PTCH1 patched 1 0.166095
FGFR2 fibroblast growth factor receptor 2 0.163111
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.162707
DUOX2 dual oxidase 2 0.160203
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.159838
ADORA2A adenosine A2a receptor 0.158778
PGF placental growth factor 0.158097
PENK proenkephalin 0.157929
ADIPOR2 adiponectin receptor 2 0.157929