fetal alcohol spectrum disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy. (Human Disease Ontology, DOID_0050696)
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Genes

225 genes co-occuring with the disease fetal alcohol spectrum disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PFAS phosphoribosylformylglycinamidine synthase 2.37938
WDR45 WD repeat domain 45 1.61396
CAMK1G calcium/calmodulin-dependent protein kinase IG 1.25254
ADH6 alcohol dehydrogenase 6 (class V) 1.23777
ACSS3 acyl-CoA synthetase short-chain family member 3 1.12277
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.09251
DIO3 deiodinase, iodothyronine, type III 1.08537
SHH sonic hedgehog 1.07572
L1CAM L1 cell adhesion molecule 1.01512
RBP1 retinol binding protein 1, cellular 1.00541
ADNP activity-dependent neuroprotector homeobox 1.00161
NOX3 NADPH oxidase 3 0.991909
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.9839
PVALB parvalbumin 0.920085
PARD6B par-6 family cell polarity regulator beta 0.906498
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.901156
ZIC5 Zic family member 5 0.893359
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.875329
ACSS1 acyl-CoA synthetase short-chain family member 1 0.863865
MSX2 msh homeobox 2 0.863865
BOLA3 bolA family member 3 0.86018
BDNF brain-derived neurotrophic factor 0.851583
TTC3 tetratricopeptide repeat domain 3 0.820847
SV2C synaptic vesicle glycoprotein 2C 0.819206
VAX2 ventral anterior homeobox 2 0.804026
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.793771
ACER3 alkaline ceramidase 3 0.792131
SGMS2 sphingomyelin synthase 2 0.791311
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.790492
SNAP25 synaptosomal-associated protein, 25kDa 0.788033
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.778613
IGF1 insulin-like growth factor 1 (somatomedin C) 0.765535
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.756564
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.754934
CUX2 cut-like homeobox 2 0.745578
RERE arginine-glutamic acid dipeptide (RE) repeats 0.738271
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.72127
ADCY8 adenylate cyclase 8 (brain) 0.716021
PAX6 paired box 6 0.713601
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.713198
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.711587
NKD2 naked cuticle homolog 2 (Drosophila) 0.710378
DMBX1 diencephalon/mesencephalon homeobox 1 0.708767
EN2 engrailed homeobox 2 0.708767
PPID peptidylprolyl isomerase D 0.703938
NOXA1 NADPH oxidase activator 1 0.698715
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.692697
DCTN2 dynactin 2 (p50) 0.681894
GRID2 glutamate receptor, ionotropic, delta 2 0.678302
CSH2 chorionic somatomammotropin hormone 2 0.671527
VIP vasoactive intestinal peptide 0.658026
NGF nerve growth factor (beta polypeptide) 0.651298
NPTX1 neuronal pentraxin I 0.648138
NOXO1 NADPH oxidase organizer 1 0.647743
DGCR2 DiGeorge syndrome critical region gene 2 0.635921
LHX6 LIM homeobox 6 0.634349
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 0.63042
LIAS lipoic acid synthetase 0.630027
FGF13 fibroblast growth factor 13 0.629242
GGT1 gamma-glutamyltransferase 1 0.623359
GLRX5 glutaredoxin 5 0.622967
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.621008
ASPH aspartate beta-hydroxylase 0.588612
RNASET2 ribonuclease T2 0.583163
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.580828
RNF25 ring finger protein 25 0.578106
NES nestin 0.577716
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.573439
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.569552
ALLC allantoicase 0.566443
CHAT choline O-acetyltransferase 0.565666
OTX2 orthodenticle homeobox 2 0.562169
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.561781
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.552463
HSF2 heat shock transcription factor 2 0.548195
CCDC6 coiled-coil domain containing 6 0.545481
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.545093
CELF2 CUGBP, Elav-like family member 2 0.535022
FZD8 frizzled class receptor 8 0.523816
FGF17 fibroblast growth factor 17 0.517649
OTX1 orthodenticle homeobox 1 0.512648
INS insulin 0.507657
FGF2 fibroblast growth factor 2 (basic) 0.50689
FA2H fatty acid 2-hydroxylase 0.50459
RXRB retinoid X receptor, beta 0.501527
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.501144
ACSS2 acyl-CoA synthetase short-chain family member 2 0.486646
VANGL1 VANGL planar cell polarity protein 1 0.486266
LIM2 lens intrinsic membrane protein 2, 19kDa 0.485885
EGLN1 egl-9 family hypoxia-inducible factor 1 0.470711
CHRD chordin 0.470332
VANGL2 VANGL planar cell polarity protein 2 0.461261
ALDOC aldolase C, fructose-bisphosphate 0.460129
DVL3 dishevelled segment polarity protein 3 0.456732
MALL mal, T-cell differentiation protein-like 0.454093
EMX2 empty spiracles homeobox 2 0.447311
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.445805
BHLHE41 basic helix-loop-helix family, member e41 0.4443
GFAP glial fibrillary acidic protein 0.4443
GLDC glycine dehydrogenase (decarboxylating) 0.434524
ADORA2A adenosine A2a receptor 0.429266
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.428516
BPIFA1 BPI fold containing family A, member 1 0.416147
DYNLL1 dynein, light chain, LC8-type 1 0.412779
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.408666
IRS1 insulin receptor substrate 1 0.407545
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.406425
ERCC6L excision repair cross-complementation group 6-like 0.394863
AADACL3 arylacetamide deacetylase-like 3 0.390769
DVL2 dishevelled segment polarity protein 2 0.389281
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.387051
PTCH2 patched 2 0.383337
WNT3A wingless-type MMTV integration site family, member 3A 0.383337
CALB2 calbindin 2 0.38111
FABP7 fatty acid binding protein 7, brain 0.377402
GPHN gephyrin 0.364085
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.363347
DCLK1 doublecortin-like kinase 1 0.35892
INSR insulin receptor 0.356341
RHOA ras homolog family member A 0.353395
FOS FBJ murine osteosarcoma viral oncogene homolog 0.351923
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.34384
CRAT carnitine O-acetyltransferase 0.342006
SOD2 superoxide dismutase 2, mitochondrial 0.339073
PLD2 phospholipase D2 0.335778
TF transferrin 0.335778
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.335046
GALC galactosylceramidase 0.334315
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.323002
SOX3 SRY (sex determining region Y)-box 3 0.318635
REST RE1-silencing transcription factor 0.312827
CAT catalase 0.312102
GREM1 gremlin 1, DAN family BMP antagonist 0.311014
EGR3 early growth response 3 0.307757
PSG9 pregnancy specific beta-1-glycoprotein 9 0.30631
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.305226
GDNF glial cell derived neurotrophic factor 0.300533
DLG4 discs, large homolog 4 (Drosophila) 0.290821
BAX BCL2-associated X protein 0.28151
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.278654
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.277584
RCAN1 regulator of calcineurin 1 0.27687
PGF placental growth factor 0.276158
MBP myelin basic protein 0.275445
BAD BCL2-associated agonist of cell death 0.271174
BOC BOC cell adhesion associated, oncogene regulated 0.269043
CELF1 CUGBP, Elav-like family member 1 0.269043
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 0.264785
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.262306
GLUL glutamate-ammonia ligase 0.260891
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.252422
F2R coagulation factor II (thrombin) receptor 0.252422
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.250311
TBX3 T-box 3 0.249257
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.248554
LCT lactase 0.248203
CALB1 calbindin 1, 28kDa 0.247501
FZD1 frizzled class receptor 1 0.243645
ADGRV1 adhesion G protein-coupled receptor V1 0.240847
HOXA1 homeobox A1 0.240148
PDLIM1 PDZ and LIM domain 1 0.23945
FKBP5 FK506 binding protein 5 0.23945
TBX5 T-box 5 0.238403
IGF2 insulin-like growth factor 2 0.238403
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.235616
EBF1 early B-cell factor 1 0.230063
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.226607
NDN necdin, melanoma antigen (MAGE) family member 0.221108
NANOG Nanog homeobox 0.221108
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.213959
ALPPL2 alkaline phosphatase, placental-like 2 0.213959
ALPP alkaline phosphatase, placental 0.213621
ALPL alkaline phosphatase, liver/bone/kidney 0.212945
OCRL oculocerebrorenal syndrome of Lowe 0.207578
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.206913
FADS2 fatty acid desaturase 2 0.203933
NSF N-ethylmaleimide-sensitive factor 0.203275
BCL2 B-cell CLL/lymphoma 2 0.200656
GPX5 glutathione peroxidase 5 0.199356
GPX4 glutathione peroxidase 4 0.196459
RARB retinoic acid receptor, beta 0.195501
LARGE like-glycosyltransferase 0.194232
GP2 glycoprotein 2 (zymogen granule membrane) 0.18651
GPX1 glutathione peroxidase 1 0.184128
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.183835
MARK3 MAP/microtubule affinity-regulating kinase 3 0.180937
LRP6 low density lipoprotein receptor-related protein 6 0.177576
NPS neuropeptide S 0.176215
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.172544
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.16933
CDC73 cell division cycle 73 0.166995
SYN1 synapsin I 0.164571
MAP7 microtubule-associated protein 7 0.164571
MECP2 methyl CpG binding protein 2 0.163729
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.160948
MAP2 microtubule-associated protein 2 0.158778
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.157765
FGFR3 fibroblast growth factor receptor 3 0.14263
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.140283
MYOG myogenin (myogenic factor 4) 0.137287
PER2 period circadian clock 2 0.136243
HEXA hexosaminidase A (alpha polypeptide) 0.135846
PER1 period circadian clock 1 0.13544
MGP matrix Gla protein 0.133953
ASRGL1 asparaginase like 1 0.131573
PLA2G1B phospholipase A2, group IB (pancreas) 0.129694
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.122619
PHYH phytanoyl-CoA 2-hydroxylase 0.122586
OLIG2 oligodendrocyte lineage transcription factor 2 0.122203
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.121383
FGFR1 fibroblast growth factor receptor 1 0.121125
DRD2 dopamine receptor D2 0.121013
ADCY2 adenylate cyclase 2 (brain) 0.120901
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.120753
DUOX1 dual oxidase 1 0.120524
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.120447
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.120216
PPARD peroxisome proliferator-activated receptor delta 0.119587
PTCH1 patched 1 0.119548
FGFR2 fibroblast growth factor receptor 2 0.118981
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.118898
DUOX2 dual oxidase 2 0.118357
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.118272
PENK proenkephalin 0.117804
ADIPOR2 adiponectin receptor 2 0.117804