fenspiride-7298 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the fenspiride-7298 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP8A bone morphogenetic protein 8a
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF46 chromosome 22 open reading frame 46
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC88C coiled-coil domain containing 88C
CCL5 chemokine (C-C motif) ligand 5
CCNO cyclin O
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP162 centrosomal protein 162kDa
CES1 carboxylesterase 1
CLCN6 chloride channel, voltage-sensitive 6
DENND4A DENN/MADD domain containing 4A
EDNRA endothelin receptor type A
EGFR epidermal growth factor receptor
EIF3F eukaryotic translation initiation factor 3, subunit F
ELAC2 elaC ribonuclease Z 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FLJ11292
FLT3LG fms-related tyrosine kinase 3 ligand
FLT4 fms-related tyrosine kinase 4
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GPC1 glypican 1
GPR107 G protein-coupled receptor 107
GRM8 glutamate receptor, metabotropic 8
GRTP1 growth hormone regulated TBC protein 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HAUS5 HAUS augmin-like complex, subunit 5
HDAC9 histone deacetylase 9
IDUA iduronidase, alpha-L-
IL1RN interleukin 1 receptor antagonist
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB5 integrin, beta 5
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIF5C kinesin family member 5C
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRK1 leucine-rich repeat kinase 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MARS methionyl-tRNA synthetase
MFAP3L microfibrillar-associated protein 3-like
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
NAG18 NAG18 mRNA
NNMT nicotinamide N-methyltransferase
NPIPB15 nuclear pore complex interacting protein family, member B15
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OVGP1 oviductal glycoprotein 1, 120kDa
PAQR6 progestin and adipoQ receptor family member VI
PEX5 peroxisomal biogenesis factor 5
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLXNB3 plexin B3
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PRSS16 protease, serine, 16 (thymus)
PSD4 pleckstrin and Sec7 domain containing 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB4B RAB4B, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RGS9 regulator of G-protein signaling 9
RPGRIP1L RPGRIP1-like
SARM1 sterile alpha and TIR motif containing 1
SCAND2P SCAN domain containing 2 pseudogene
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERGEF secretion regulating guanine nucleotide exchange factor
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SOS2 son of sevenless homolog 2 (Drosophila)
SOX2 SRY (sex determining region Y)-box 2
SP100 SP100 nuclear antigen
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SSX3 synovial sarcoma, X breakpoint 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYNJ2 synaptojanin 2
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast)
TJAP1 tight junction associated protein 1 (peripheral)
TLN2 talin 2
TLX3 T-cell leukemia homeobox 3
TM2D1 TM2 domain containing 1
TMEM63A transmembrane protein 63A
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNS1 tensin 1
TSPYL2 TSPY-like 2
TTLL1 tubulin tyrosine ligase-like family member 1
TTLL7 tubulin tyrosine ligase-like family member 7
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WIPF1 WAS/WASL interacting protein family, member 1
ZBTB7A zinc finger and BTB domain containing 7A
ZFAND5 zinc finger, AN1-type domain 5
ZNF253 zinc finger protein 253
ZNF440 zinc finger protein 440
ZNF446 zinc finger protein 446

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADGRF1 adhesion G protein-coupled receptor F1
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AFAP1 actin filament associated protein 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKTIP AKT interacting protein
AP1AR adaptor-related protein complex 1 associated regulatory protein
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C1ORF27 chromosome 1 open reading frame 27
CAPN15 calpain 15
CCNT1 cyclin T1
CFAP69 cilia and flagella associated protein 69
CHMP6 charged multivesicular body protein 6
CLDN7 claudin 7
CSK c-src tyrosine kinase
CST6 cystatin E/M
CTSK cathepsin K
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGAT1 diacylglycerol O-acyltransferase 1
DLK1 delta-like 1 homolog (Drosophila)
EDC3 enhancer of mRNA decapping 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELP3 elongator acetyltransferase complex subunit 3
ETNK2 ethanolamine kinase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM193B family with sequence similarity 193, member B
FAM222B family with sequence similarity 222, member B
FGD6 FYVE, RhoGEF and PH domain containing 6
FKBP1B FK506 binding protein 1B, 12.6 kDa
GLTSCR1 glioma tumor suppressor candidate region gene 1
HINFP histone H4 transcription factor
HIST1H2AM histone cluster 1, H2am
HLX H2.0-like homeobox
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPB8 heat shock 22kDa protein 8
ICK intestinal cell (MAK-like) kinase
IGFLR1 IGF-like family receptor 1
IL17RA interleukin 17 receptor A
IRS2 insulin receptor substrate 2
KATNBL1 katanin p80 subunit B-like 1
KIAA0319L KIAA0319-like
KIAA1462 KIAA1462
LIMS2 LIM and senescent cell antigen-like domains 2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MANBA mannosidase, beta A, lysosomal
MAST3 microtubule associated serine/threonine kinase 3
MRPL44 mitochondrial ribosomal protein L44
NARFL nuclear prelamin A recognition factor-like
NDRG4 NDRG family member 4
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NUPL2 nucleoporin like 2
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCOLCE procollagen C-endopeptidase enhancer
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD2 phospholipase D2
POR P450 (cytochrome) oxidoreductase
PPT2 palmitoyl-protein thioesterase 2
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB33B RAB33B, member RAS oncogene family
RASA2 RAS p21 protein activator 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS17P5 ribosomal protein S17 pseudogene 5
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPAG7 sperm associated antigen 7
SPATA7 spermatogenesis associated 7
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STAR steroidogenic acute regulatory protein
SUGCT succinyl-CoA:glutarate-CoA transferase
SUGP1 SURP and G patch domain containing 1
TKFC triokinase/FMN cyclase
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TNNI3 troponin I type 3 (cardiac)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBGCP5 tubulin, gamma complex associated protein 5
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF16 zinc finger protein 16
ZNF354A zinc finger protein 354A
ZNF562 zinc finger protein 562
ZNF574 zinc finger protein 574