female reproductive system disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes. (Human Disease Ontology, DOID_229)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:229
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Genes

193 genes associated with the disease female reproductive system disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.20161
NPR3 natriuretic peptide receptor 3 1.19386
PVALB parvalbumin 1.14463
EPC1 enhancer of polycomb homolog 1 (Drosophila) 1.14463
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.965486
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.568627
ZFAT zinc finger and AT hook domain containing 0.566448
MPDU1 mannose-P-dolichol utilization defect 1 0.503089
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.500851
CDKN2B-AS1 CDKN2B antisense RNA 1 0.427965
WNT4 wingless-type MMTV integration site family, member 4 0.382185
GREB1 growth regulation by estrogen in breast cancer 1 0.375573
COL18A1 collagen, type XVIII, alpha 1 0.374658
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.358446
GYS1 glycogen synthase 1 (muscle) 0.357293
IL1R2 interleukin 1 receptor, type II 0.348723
FGD6 FYVE, RhoGEF and PH domain containing 6 0.342736
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.340107
VEZT vezatin, adherens junctions transmembrane protein 0.329632
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 0.327041
GLDN gliomedin 0.325172
IL33 interleukin 33 0.321746
ADGB androglobin 0.320318
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.320318
ATRNL1 attractin-like 1 0.314867
CEP112 centrosomal protein 112kDa 0.312437
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 0.311719
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.31104
CALD1 caldesmon 1 0.309192
MAST4 microtubule associated serine/threonine kinase family member 4 0.307578
FHOD3 formin homology 2 domain containing 3 0.300603
MKKS McKusick-Kaufman syndrome 0.299489
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.292233
ARMC9 armadillo repeat containing 9 0.292233
KSR2 kinase suppressor of ras 2 0.292233
ZFPM1 zinc finger protein, FOG family member 1 0.290169
SYNE1 spectrin repeat containing, nuclear envelope 1 0.289977
ESR1 estrogen receptor 1 0.28705
FLJ40288 uncharacterized FLJ40288 0.286741
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.283301
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.280005
CCDC33 coiled-coil domain containing 33 0.277441
FN1 fibronectin 1 0.277441
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.274453
DNMBP dynamin binding protein 0.27271
TM7SF3 transmembrane 7 superfamily member 3 0.271899
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.271277
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 0.271125
PGR progesterone receptor 0.265925
BCAP29 B-cell receptor-associated protein 29 0.265925
DNM3 dynamin 3 0.264318
ANGPT1 angiopoietin 1 0.262386
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.260649
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 0.260041
SNTA1 syntrophin, alpha 1 0.259843
MCC mutated in colorectal cancers 0.259843
FHIT fragile histidine triad 0.255241
ALG8 ALG8, alpha-1,3-glucosyltransferase 0.253203
ARHGAP24 Rho GTPase activating protein 24 0.253171
PLXDC2 plexin domain containing 2 0.252915
C6ORF106 chromosome 6 open reading frame 106 0.252568
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.252568
RPE65 retinal pigment epithelium-specific protein 65kDa 0.252568
FXYD3 FXYD domain containing ion transport regulator 3 0.251954
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.251954
MRVI1 murine retrovirus integration site 1 homolog 0.251654
FGG fibrinogen gamma chain 0.251068
DCP2 decapping mRNA 2 0.250838
SEPW1 selenoprotein W, 1 0.250781
PGLYRP3 peptidoglycan recognition protein 3 0.250781
SCARA5 scavenger receptor class A, member 5 0.250639
TFAP2D transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 0.249409
COL4A2 collagen, type IV, alpha 2 0.247638
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.247161
GADL1 glutamate decarboxylase-like 1 0.246926
MTMR3 myotubularin related protein 3 0.24624
NEK11 NIMA-related kinase 11 0.245818
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.244157
PUM2 pumilio RNA-binding family member 2 0.244017
PERP PERP, TP53 apoptosis effector 0.242207
IL17RC interleukin 17 receptor C 0.242026
PXMP4 peroxisomal membrane protein 4, 24kDa 0.242026
ONECUT3 one cut homeobox 3 0.240307
NRP1 neuropilin 1 0.237277
KIAA1217 KIAA1217 0.236591
NFASC neurofascin 0.235928
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 0.235928
IFNLR1 interferon, lambda receptor 1 0.23467
ZNF831 zinc finger protein 831 0.233838
CSMD1 CUB and Sushi multiple domains 1 0.233606
WNT3A wingless-type MMTV integration site family, member 3A 0.233492
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.233265
UPK1B uroplakin 1B 0.231136
FNDC3B fibronectin type III domain containing 3B 0.231036
EPHA4 EPH receptor A4 0.230252
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.230157
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.228001
VCL vinculin 0.227632
RMDN2 regulator of microtubule dynamics 2 0.226564
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 0.224902
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.223077
NPAP1 nuclear pore associated protein 1 0.223077
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.222789
CADM2 cell adhesion molecule 2 0.222504
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.222504
AMPH amphiphysin 0.221274
SACS sacsin molecular chaperone 0.22101
HEG1 heart development protein with EGF-like domains 1 0.220241
NUP98 nucleoporin 98kDa 0.219991
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.219929
MAPK14 mitogen-activated protein kinase 14 0.217164
WDR26 WD repeat domain 26 0.217057
DOCK1 dedicator of cytokinesis 1 0.216634
LRP1B low density lipoprotein receptor-related protein 1B 0.216068
NIN ninein (GSK3B interacting protein) 0.215617
AQP9 aquaporin 9 0.215419
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 0.215321
BAHCC1 BAH domain and coiled-coil containing 1 0.215273
HUNK hormonally up-regulated Neu-associated kinase 0.214982
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.213153
SNX27 sorting nexin family member 27 0.212806
PRKG1 protein kinase, cGMP-dependent, type I 0.212678
SPAG17 sperm associated antigen 17 0.212341
PVT1 Pvt1 oncogene (non-protein coding) 0.212174
PTCRA pre T-cell antigen receptor alpha 0.21205
CDC42SE1 CDC42 small effector 1 0.211968
PDGFD platelet derived growth factor D 0.211763
CACHD1 cache domain containing 1 0.210813
CSMD2 CUB and Sushi multiple domains 2 0.210813
GRID2 glutamate receptor, ionotropic, delta 2 0.210242
PARD3B par-3 family cell polarity regulator beta 0.210167
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.210092
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.20987
MR1 major histocompatibility complex, class I-related 0.209797
SASH1 SAM and SH3 domain containing 1 0.209042
IGF2R insulin-like growth factor 2 receptor 0.208867
NCKAP5 NCK-associated protein 5 0.20859
FRYL FRY-like 0.208317
NELL2 NEL-like 2 (chicken) 0.208181
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.207947
SLC44A3 solute carrier family 44, member 3 0.207781
PAX8 paired box 8 0.207683
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 0.207487
HELQ helicase, POLQ-like 0.207101
FBLIM1 filamin binding LIM protein 1 0.206943
BTBD9 BTB (POZ) domain containing 9 0.20688
KIAA0226L KIAA0226-like 0.206848
ATP8B4 ATPase, class I, type 8B, member 4 0.206755
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.206506
LOXHD1 lipoxygenase homology domains 1 0.206414
TUBA8 tubulin, alpha 8 0.205869
DOCK2 dedicator of cytokinesis 2 0.205662
NLGN1 neuroligin 1 0.205574
MAP3K6 mitogen-activated protein kinase kinase kinase 6 0.205456
ZDHHC14 zinc finger, DHHC-type containing 14 0.205167
CYYR1 cysteine/tyrosine-rich 1 0.204825
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.204825
DROSHA drosha, ribonuclease type III 0.203863
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.20357
TPRG1 tumor protein p63 regulated 1 0.203282
ESPNL espin-like 0.203204
INTS9 integrator complex subunit 9 0.202693
SLC35F3 solute carrier family 35, member F3 0.202467
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.202368
WWOX WW domain containing oxidoreductase 0.201927
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.201807
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.201783
PANX1 pannexin 1 0.201497
MYOM2 myomesin 2 0.201108
BDNF-AS BDNF antisense RNA 0.200831
RNF165 ring finger protein 165 0.200756
DNHD1 dynein heavy chain domain 1 0.200707
PTPRT protein tyrosine phosphatase, receptor type, T 0.199904
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 0.199904
ZNF423 zinc finger protein 423 0.199785
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.199643
MGC27382 uncharacterized MGC27382 0.199549
TLR10 toll-like receptor 10 0.199549
MST1 macrophage stimulating 1 0.199131
ASCC2 activating signal cointegrator 1 complex subunit 2 0.199085
THSD4 thrombospondin, type I, domain containing 4 0.199062
PKD1L1 polycystic kidney disease 1 like 1 0.198903
FRMD4A FERM domain containing 4A 0.198857
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.198857
GPR158 G protein-coupled receptor 158 0.198387
DISC1 disrupted in schizophrenia 1 0.198387
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.198321
MYO5C myosin VC 0.198233
C5ORF22 chromosome 5 open reading frame 22 0.198233
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 0.198189
SCFD2 sec1 family domain containing 2 0.198123
TBX15 T-box 15 0.198101
TMEM164 transmembrane protein 164 0.197971