fatty liver disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis. (Human Disease Ontology, DOID_9452)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:9452
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Genes

197 genes associated with the disease fatty liver disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
ICAM1 intercellular adhesion molecule 1 3.16684
ICAM5 intercellular adhesion molecule 5, telencephalin 2.90901
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.58403
S1PR2 sphingosine-1-phosphate receptor 2 2.52397
MRPL4 mitochondrial ribosomal protein L4 2.49511
PNPLA3 patatin-like phospholipase domain containing 3 2.33768
ICAM3 intercellular adhesion molecule 3 2.27219
PDE4A phosphodiesterase 4A, cAMP-specific 2.12956
RAVER1 ribonucleoprotein, PTB-binding 1 1.94356
LOC157273 uncharacterized LOC157273 1.93582
SH2B3 SH2B adaptor protein 3 1.9037
ATXN2 ataxin 2 1.90229
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.85972
CDC37 cell division cycle 37 1.85188
SAMM50 SAMM50 sorting and assembly machinery component 1.78054
PARVB parvin, beta 1.68591
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.66022
NCAN neurocan 1.63343
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.57284
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.53777
TYK2 tyrosine kinase 2 1.49081
COL13A1 collagen, type XIII, alpha 1 1.28906
TP63 tumor protein p63 1.22806
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.21996
CRACR2A calcium release activated channel regulator 2A 1.21019
EHBP1L1 EH domain binding protein 1-like 1 1.20161
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 1.14463
SLC38A8 solute carrier family 38, member 8 1.14463
TMEM56-RWDD3 TMEM56-RWDD3 readthrough 1.14463
LOC643339 uncharacterized LOC643339 1.10764
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 1.10764
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 1.10764
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 1.07599
YIPF1 Yip1 domain family, member 1 1.04846
MSRA methionine sulfoxide reductase A 1.02006
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 1.00407
MACROD2 MACRO domain containing 2 1.00407
DCLK1 doublecortin-like kinase 1 1.00407
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.00407
SLC46A3 solute carrier family 46, member 3 0.971169
ARL15 ADP-ribosylation factor-like 15 0.893189
RBMS3 RNA binding motif, single stranded interacting protein 3 0.890183
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.810175
SHROOM3 shroom family member 3 0.74567
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.722241
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.722241
PARK2 parkin RBR E3 ubiquitin protein ligase 0.692747
ATXN10 ataxin 10 0.692747
CAND1 cullin-associated and neddylation-dissociated 1 0.692747
SCN5A sodium channel, voltage gated, type V alpha subunit 0.692747
ZSCAN16 zinc finger and SCAN domain containing 16 0.692747
SYN3 synapsin III 0.692747
SASH1 SAM and SH3 domain containing 1 0.692747
SLC44A4 solute carrier family 44, member 4 0.691618
MIER2 mesoderm induction early response 1, family member 2 0.691618
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.691457
JARID2 jumonji, AT rich interactive domain 2 0.689397
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.686305
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.686305
CCDC28A coiled-coil domain containing 28A 0.686153
RHOBTB1 Rho-related BTB domain containing 1 0.685546
LOC729950 uncharacterized LOC729950 0.685546
HCG18 HLA complex group 18 (non-protein coding) 0.685546
SHISA6 shisa family member 6 0.685546
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.685546
RCSD1 RCSD domain containing 1 0.685546
FFAR4 free fatty acid receptor 4 0.685546
TMEM132D transmembrane protein 132D 0.685546
LINC00483 long intergenic non-protein coding RNA 483 0.685395
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.685395
KAZN kazrin, periplakin interacting protein 0.685395
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 0.685395
SDK1 sidekick cell adhesion molecule 1 0.680967
RYR2 ryanodine receptor 2 (cardiac) 0.680967
CRYL1 crystallin, lambda 1 0.679818
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.678541
ZNF212 zinc finger protein 212 0.676035
ZNF282 zinc finger protein 282 0.675898
DSCAM Down syndrome cell adhesion molecule 0.675898
LINC00511 long intergenic non-protein coding RNA 511 0.675898
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.675898
SCAPER S-phase cyclin A-associated protein in the ER 0.675898
CELF2 CUGBP, Elav-like family member 2 0.675898
CCR6 chemokine (C-C motif) receptor 6 0.675898
NTM neurotrimin 0.675898
USP48 ubiquitin specific peptidase 48 0.675898
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.675898
SLC45A1 solute carrier family 45, member 1 0.675898
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.675898
C4ORF50 chromosome 4 open reading frame 50 0.675898
LOC100132891 0.675898
CGNL1 cingulin-like 1 0.675898
PDGFC platelet derived growth factor C 0.675898
GPM6A glycoprotein M6A 0.675898
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.675898
TRIOBP TRIO and F-actin binding protein 0.675898
PDE4D phosphodiesterase 4D, cAMP-specific 0.675898
IGF1R insulin-like growth factor 1 receptor 0.67535
NUSAP1 nucleolar and spindle associated protein 1 0.67535
ESR1 estrogen receptor 1 0.67535
EGFR epidermal growth factor receptor 0.67535
COL19A1 collagen, type XIX, alpha 1 0.67535
MCF2L MCF.2 cell line derived transforming sequence-like 0.67535
PALLD palladin, cytoskeletal associated protein 0.67535
DZANK1 double zinc ribbon and ankyrin repeat domains 1 0.67535
UST uronyl-2-sulfotransferase 0.67535
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.67535
ELOVL6 ELOVL fatty acid elongase 6 0.67535
LRP1B low density lipoprotein receptor-related protein 1B 0.67535
RAB31 RAB31, member RAS oncogene family 0.67535
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.67535
PRKCB protein kinase C, beta 0.67535
EFNA1 ephrin-A1 0.67535
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.67535
NCLN nicalin 0.67535
SH2D3C SH2 domain containing 3C 0.67535
CER1 cerberus 1, DAN family BMP antagonist 0.67535
STK19 serine/threonine kinase 19 0.67535
TTPAL tocopherol (alpha) transfer protein-like 0.67535
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.67535
DIAPH3 diaphanous-related formin 3 0.67535
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.67535
SBF2 SET binding factor 2 0.67535
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.67535
ARHGAP42 Rho GTPase activating protein 42 0.67535
TCTN2 tectonic family member 2 0.67535
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.67535
FAN1 FANCD2/FANCI-associated nuclease 1 0.67535
DRC1 dynein regulatory complex subunit 1 0.67535
CNGB1 cyclic nucleotide gated channel beta 1 0.67535
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 0.67535
BANF2 barrier to autointegration factor 2 0.67535
NELL1 NEL-like 1 (chicken) 0.67535
FLRT3 fibronectin leucine rich transmembrane protein 3 0.67535
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.67535
ADAMTSL4 ADAMTS-like 4 0.67535
CD48 CD48 molecule 0.673725
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.67359
LAMC2 laminin, gamma 2 0.67359
ARID5B AT rich interactive domain 5B (MRF1-like) 0.67359
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.67359
TJP2 tight junction protein 2 0.67359
EPHA5 EPH receptor A5 0.67359
TIAM1 T-cell lymphoma invasion and metastasis 1 0.673189
C7ORF33 chromosome 7 open reading frame 33 0.673189
MYO5C myosin VC 0.673189
TMEM132B transmembrane protein 132B 0.672789
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.672789
FLJ45831 0.672789
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.672656
MIR31HG MIR31 host gene 0.672656
ACER2 alkaline ceramidase 2 0.672656
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.672656
HOPX HOP homeobox 0.672656
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.672656
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.672656
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.672656
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.672656
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.672656
LINC00536 long intergenic non-protein coding RNA 536 0.672656
LOC100506207 uncharacterized LOC100506207 0.672656
COL4A1 collagen, type IV, alpha 1 0.672656
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.672656
NALCN sodium leak channel, non selective 0.672656
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.672656
ZSCAN23 zinc finger and SCAN domain containing 23 0.672656
LRRC2 leucine rich repeat containing 2 0.672656
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.672656
FRMD6 FERM domain containing 6 0.672656
ANK2 ankyrin 2, neuronal 0.672656
THTPA thiamine triphosphatase 0.672656
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.672656
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.672656
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.672258
TPRG1 tumor protein p63 regulated 1 0.671993
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.671598
TMEM56 transmembrane protein 56 0.671205
NRG1 neuregulin 1 0.670682
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.670567
MYOM3 myomesin 3 0.670567
NCAM1 neural cell adhesion molecule 1 0.670567
EYS eyes shut homolog (Drosophila) 0.670567
IQGAP1 IQ motif containing GTPase activating protein 1 0.670258
TMEM163 transmembrane protein 163 0.670258
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.670258
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.652472
TECRL trans-2,3-enoyl-CoA reductase-like 0.635081
FAM208A family with sequence similarity 208, member A 0.625701
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.616096
PLD5 phospholipase D family, member 5 0.615118
GCKR glucokinase (hexokinase 4) regulator 0.597957
CC2D2A coiled-coil and C2 domain containing 2A 0.596242
ATXN7L1 ataxin 7-like 1 0.595401
ZHX2 zinc fingers and homeoboxes 2 0.589557
PTPRG protein tyrosine phosphatase, receptor type, G 0.58124
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.557222
RYR3 ryanodine receptor 3 0.517633