fatty liver disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis. (Human Disease Ontology, DOID_9452)
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Genes

369 genes co-occuring with the disease fatty liver disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PNPLA3 patatin-like phospholipase domain containing 3 2.46582
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 2.27637
GOT1 glutamic-oxaloacetic transaminase 1, soluble 2.25848
SREBF1 sterol regulatory element binding transcription factor 1 2.20309
INS insulin 2.03966
LEP leptin 1.92108
FASN fatty acid synthase 1.88251
GGT1 gamma-glutamyltransferase 1 1.84363
PPARA peroxisome proliferator-activated receptor alpha 1.71134
PPARG peroxisome proliferator-activated receptor gamma 1.69678
KRT18 keratin 18, type I 1.58448
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.55956
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.54893
RETN resistin 1.54716
GGT2 gamma-glutamyltransferase 2 1.51106
MTTP microsomal triglyceride transfer protein 1.50711
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.49701
FGF21 fibroblast growth factor 21 1.47067
MLXIPL MLX interacting protein-like 1.44167
ACACA acetyl-CoA carboxylase alpha 1.43113
SREBF2 sterol regulatory element binding transcription factor 2 1.42586
RBP4 retinol binding protein 4, plasma 1.38385
SIRT1 sirtuin 1 1.37774
CPT1A carnitine palmitoyltransferase 1A (liver) 1.3603
CRP C-reactive protein, pentraxin-related 1.32672
ADIPOR2 adiponectin receptor 2 1.30095
TNF tumor necrosis factor 1.28348
FTH1 ferritin, heavy polypeptide 1 1.28261
FTL ferritin, light polypeptide 1.27563
FBL fibrillarin 1.25994
DGAT2 diacylglycerol O-acyltransferase 2 1.24993
ALPP alkaline phosphatase, placental 1.23343
ALPPL2 alkaline phosphatase, placental-like 2 1.22865
ALPL alkaline phosphatase, liver/bone/kidney 1.22779
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.21045
FBLL1 fibrillarin-like 1 1.19618
TM6SF2 transmembrane 6 superfamily member 2 1.16093
AHSG alpha-2-HS-glycoprotein 1.15453
PPP1R3B protein phosphatase 1, regulatory subunit 3B 1.1524
IRS2 insulin receptor substrate 2 1.12614
HFE hemochromatosis 1.12572
ADIPOR1 adiponectin receptor 1 1.11772
PLIN2 perilipin 2 1.11393
LYPLAL1 lysophospholipase-like 1 1.11267
APOB apolipoprotein B 1.11141
CD36 CD36 molecule (thrombospondin receptor) 1.11057
IL6 interleukin 6 1.10594
CRACR2A calcium release activated channel regulator 2A 1.09041
NPC1L1 NPC1-like 1 1.08831
NCAN neurocan 1.08244
LPIN1 lipin 1 1.0774
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 1.07026
NAMPT nicotinamide phosphoribosyltransferase 1.06942
PLIN1 perilipin 1 1.05429
ACOX1 acyl-CoA oxidase 1, palmitoyl 1.0463
PNPLA5 patatin-like phospholipase domain containing 5 1.0463
XBP1 X-box binding protein 1 1.03788
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 1.01427
BAAT bile acid CoA:amino acid N-acyltransferase 0.995705
DGAT1 diacylglycerol O-acyltransferase 1 0.993596
APOC3 apolipoprotein C-III 0.979689
LIPE lipase, hormone-sensitive 0.978006
CLEC4F C-type lectin domain family 4, member F 0.975482
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.975062
SOD2 superoxide dismutase 2, mitochondrial 0.9696
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.959123
TLR4 toll-like receptor 4 0.955779
FOXO1 forkhead box O1 0.952438
SCARB2 scavenger receptor class B, member 2 0.951604
LEPR leptin receptor 0.944938
IRS1 insulin receptor substrate 1 0.944521
PNPLA2 patatin-like phospholipase domain containing 2 0.944106
SCARB1 scavenger receptor class B, member 1 0.932898
ACADL acyl-CoA dehydrogenase, long chain 0.931242
GPBAR1 G protein-coupled bile acid receptor 1 0.925865
JUN jun proto-oncogene 0.924626
CCL2 chemokine (C-C motif) ligand 2 0.915551
HAMP hepcidin antimicrobial peptide 0.913903
LDLR low density lipoprotein receptor 0.900746
PEMT phosphatidylethanolamine N-methyltransferase 0.900335
COG2 component of oligomeric golgi complex 2 0.893359
ALB albumin 0.888029
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.879833
INSR insulin receptor 0.879424
TF transferrin 0.844211
GLT8D2 glycosyltransferase 8 domain containing 2 0.842982
FABP4 fatty acid binding protein 4, adipocyte 0.839296
PARVB parvin, beta 0.825358
COL13A1 collagen, type XIII, alpha 1 0.824128
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.817155
FITM1 fat storage-inducing transmembrane protein 1 0.808129
AQP9 aquaporin 9 0.801564
FAM3A family with sequence similarity 3, member A 0.792951
MAPK8 mitogen-activated protein kinase 8 0.779023
CNR1 cannabinoid receptor 1 (brain) 0.778613
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.763902
GCKR glucokinase (hexokinase 4) regulator 0.748424
DPP4 dipeptidyl-peptidase 4 0.741923
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.741923
GCG glucagon 0.730571
SLC25A47 solute carrier family 25, member 47 0.726929
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 0.711183
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.707961
TFAM transcription factor A, mitochondrial 0.705547
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.70434
GHRL ghrelin/obestatin prepropeptide 0.701526
GPX1 glutathione peroxidase 1 0.690694
ATF4 activating transcription factor 4 0.688692
IKBIP IKBKB interacting protein 0.687091
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.685491
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 0.681096
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.678701
CLK2 CDC-like kinase 2 0.677504
GNMT glycine N-methyltransferase 0.677105
INSIG1 insulin induced gene 1 0.676706
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.67312
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.671925
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 0.669538
GPX5 glutathione peroxidase 5 0.668345
CAT catalase 0.66596
GPX4 glutathione peroxidase 4 0.664769
MOGAT1 monoacylglycerol O-acyltransferase 1 0.65565
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 0.653671
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 0.653276
PNO1 partner of NOB1 homolog (S. cerevisiae) 0.653276
IGF1 insulin-like growth factor 1 (somatomedin C) 0.649718
KLF6 Kruppel-like factor 6 0.627672
GRB2 growth factor receptor-bound protein 2 0.624927
PLIN4 perilipin 4 0.615138
GLP1R glucagon-like peptide 1 receptor 0.613183
ACSL1 acyl-CoA synthetase long-chain family member 1 0.59952
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 0.594064
CES1 carboxylesterase 1 0.591727
ELOVL3 ELOVL fatty acid elongase 3 0.587444
FANK1 fibronectin type III and ankyrin repeat domains 1 0.587054
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.585497
PZP pregnancy-zone protein 0.584719
DDIT3 DNA-damage-inducible transcript 3 0.584719
RGN regucalcin 0.58433
ATF6 activating transcription factor 6 0.58433
OCLN occludin 0.581996
CIDEC cell death-inducing DFFA-like effector c 0.575383
PLIN3 perilipin 3 0.569941
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 0.568386
ABHD5 abhydrolase domain containing 5 0.565277
FABP1 fatty acid binding protein 1, liver 0.560616
STARD4 StAR-related lipid transfer (START) domain containing 4 0.551298
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.543155
LPL lipoprotein lipase 0.541217
FADS1 fatty acid desaturase 1 0.536957
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.536183
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.531928
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.521502
SAMM50 SAMM50 sorting and assembly machinery component 0.520731
ACLY ATP citrate lyase 0.516879
CHPF2 chondroitin polymerizing factor 2 0.515725
SLC38A8 solute carrier family 38, member 8 0.512264
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.508041
MYD88 myeloid differentiation primary response 88 0.507273
GAPT GRB2-binding adaptor protein, transmembrane 0.506507
UBXN1 UBX domain protein 1 0.506507
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.503824
SOCS3 suppressor of cytokine signaling 3 0.500761
PLIN5 perilipin 5 0.499997
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.498467
SHBG sex hormone-binding globulin 0.491215
INSIG2 insulin induced gene 2 0.490454
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 0.489691
MOGAT3 monoacylglycerol O-acyltransferase 3 0.489691
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 0.488549
G6PC glucose-6-phosphatase, catalytic subunit 0.483985
NLRP6 NLR family, pyrin domain containing 6 0.483985
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.483604
FGF19 fibroblast growth factor 19 0.481325
FITM2 fat storage-inducing transmembrane protein 2 0.477909
SIRT4 sirtuin 4 0.47753
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 0.476772
ABHD6 abhydrolase domain containing 6 0.476393
APOE apolipoprotein E 0.475634
CMKLR1 chemerin chemokine-like receptor 1 0.474498
FAM3B family with sequence similarity 3, member B 0.474119
FAM3D family with sequence similarity 3, member D 0.469954
ZNF267 zinc finger protein 267 0.468441
CD1D CD1d molecule 0.468063
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.466928
IFNL3 interferon, lambda 3 0.463905
TIMP1 TIMP metallopeptidase inhibitor 1 0.460883
UGCG UDP-glucose ceramide glucosyltransferase 0.460506
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.459373
HINT2 histidine triad nucleotide binding protein 2 0.457487
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 0.456355
SIRT7 sirtuin 7 0.451831
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.448817
GCLC glutamate-cysteine ligase, catalytic subunit 0.445805
AGRP agouti related neuropeptide 0.443923
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 0.441666
ARFRP1 ADP-ribosylation factor related protein 1 0.440538
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.439034
LPPR4 lipid phosphate phosphatase-related protein type 4 0.438658
MC3R melanocortin 3 receptor 0.436778
CD68 CD68 molecule 0.431144
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.42739
MAP2K4 mitogen-activated protein kinase kinase 4 0.427015
USP25 ubiquitin specific peptidase 25 0.419892
HP haptoglobin 0.416147
HPR haptoglobin-related protein 0.410161
TFB2M transcription factor B2, mitochondrial 0.409787
NRF1 nuclear respiratory factor 1 0.408666
SDCBP syndecan binding protein (syntenin) 0.408292
CFD complement factor D (adipsin) 0.402318
TGFB1 transforming growth factor, beta 1 0.401199
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.39598
MC4R melanocortin 4 receptor 0.395235
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 0.393374
CSN1S1 casein alpha s1 0.393001
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.392257
F2 coagulation factor II (thrombin) 0.383708
CHUK conserved helix-loop-helix ubiquitous kinase 0.380368
CP ceruloplasmin (ferroxidase) 0.373698
BHMT betaine--homocysteine S-methyltransferase 0.372587
CXCL8 chemokine (C-X-C motif) ligand 8 0.371847
APOA1 apolipoprotein A-I 0.369997
COQ9 coenzyme Q9 0.358183
SIRT3 sirtuin 3 0.357814
POR P450 (cytochrome) oxidoreductase 0.356709
MOGAT2 monoacylglycerol O-acyltransferase 2 0.355972
MIR197 microRNA 197 0.355972
NLRP3 NLR family, pyrin domain containing 3 0.354499
ELOVL6 ELOVL fatty acid elongase 6 0.354499
UGT2A3 UDP glucuronosyltransferase 2 family, polypeptide A3 0.353763
CCDC112 coiled-coil domain containing 112 0.350084
AQP10 aquaporin 10 0.347879
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.346777
PTMS parathymosin 0.346777
TFB1M transcription factor B1, mitochondrial 0.345308
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.344574
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 0.344207
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.342372
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.33944
ACSL6 acyl-CoA synthetase long-chain family member 6 0.331756
FGL1 fibrinogen-like 1 0.32774
MAPK4 mitogen-activated protein kinase 4 0.32701
ACACB acetyl-CoA carboxylase beta 0.324823
C8G complement component 8, gamma polypeptide 0.324458
NPAS2 neuronal PAS domain protein 2 0.320817
THRSP thyroid hormone responsive 0.316819
GLOD4 glyoxalase domain containing 4 0.314278
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 0.312827
ACOX3 acyl-CoA oxidase 3, pristanoyl 0.310652
TRIB1 tribbles pseudokinase 1 0.305587
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.299812
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.299452
AHR aryl hydrocarbon receptor 0.298011
IL18 interleukin 18 0.297651
TFR2 transferrin receptor 2 0.290821
KLK15 kallikrein-related peptidase 15 0.290103
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.283655
LCN2 lipocalin 2 0.282582
TXN thioredoxin 0.28151
SORD sorbitol dehydrogenase 0.280796
MAPK9 mitogen-activated protein kinase 9 0.280439
FABP3 fatty acid binding protein 3, muscle and heart 0.279367
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.278297
FADS2 fatty acid desaturase 2 0.27687
SPP1 secreted phosphoprotein 1 0.274732
AADAC arylacetamide deacetylase 0.273664
SIRT6 sirtuin 6 0.273308
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.272597
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.272241
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.270819
CER1 cerberus 1, DAN family BMP antagonist 0.267267
NDC1 NDC1 transmembrane nucleoporin 0.267267
FABP7 fatty acid binding protein 7, brain 0.266558
BAX BCL2-associated X protein 0.265494
STK11 serine/threonine kinase 11 0.265494
HMOX1 heme oxygenase 1 0.265494
PC pyruvate carboxylase 0.26514
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.264785
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.263014
PTEN phosphatase and tensin homolog 0.251718
TGM4 transglutaminase 4 0.248203
GSTM1 glutathione S-transferase mu 1 0.247852
ENHO energy homeostasis associated 0.247501
ZNF274 zinc finger protein 274 0.245396
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 0.240497
PLG plasminogen 0.23945
PRKX protein kinase, X-linked 0.238054
APOA5 apolipoprotein A-V 0.237706
NOS3 nitric oxide synthase 3 (endothelial cell) 0.233878
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.233183
ADGRE2 adhesion G protein-coupled receptor E2 0.231795
NLRX1 NLR family member X1 0.231795
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.231795
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.230409
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.230409
GPC4 glypican 4 0.230063
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 0.229024
CRY2 cryptochrome circadian clock 2 0.22454
IL1B interleukin 1, beta 0.22145
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.218715
GCK glucokinase (hexokinase 4) 0.218374
RXRA retinoid X receptor, alpha 0.217012
DMBX1 diencephalon/mesencephalon homeobox 1 0.216332
CROT carnitine O-octanoyltransferase 0.214636
GSS glutathione synthetase 0.213621
RSPO1 R-spondin 1 0.207912
LMBRD1 LMBR1 domain containing 1 0.207245
CS citrate synthase 0.203604
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.203275
CREB3L3 cAMP responsive element binding protein 3-like 3 0.202946
IGFBP3 insulin-like growth factor binding protein 3 0.202946
TLR2 toll-like receptor 2 0.201962
ACSL5 acyl-CoA synthetase long-chain family member 5 0.200982
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.198386
CPT2 carnitine palmitoyltransferase 2 0.198064
JAK2 Janus kinase 2 0.197099
FGF1 fibroblast growth factor 1 (acidic) 0.196779
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 0.196139
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.195501
FABP2 fatty acid binding protein 2, intestinal 0.194548
RPL29 ribosomal protein L29 0.1936
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.192657
VPREB1 pre-B lymphocyte 1 0.191097
PDE1B phosphodiesterase 1B, calmodulin-dependent 0.187415
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.187415
VCAM1 vascular cell adhesion molecule 1 0.187415
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 0.186811
NNMT nicotinamide N-methyltransferase 0.18591
EPHX2 epoxide hydrolase 2, cytoplasmic 0.185313
SOAT2 sterol O-acyltransferase 2 0.183835
NANS N-acetylneuraminic acid synthase 0.182957
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.182375
LPA lipoprotein, Lp(a) 0.182086
SP6 Sp6 transcription factor 0.180937
CDH13 cadherin 13 0.179239
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.177851
FST follistatin 0.177576
CRY1 cryptochrome circadian clock 1 0.177029
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.176215
LPXN leupaxin 0.175947
ERN1 endoplasmic reticulum to nucleus signaling 1 0.174354
SETD7 SET domain containing (lysine methyltransferase) 7 0.173571
CASP2 caspase 2, apoptosis-related cysteine peptidase 0.173314
ZP4 zona pellucida glycoprotein 4 0.172799
NASP nuclear autoantigenic sperm protein (histone-binding) 0.172799
FAT1 FAT atypical cadherin 1 0.172799
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 0.170054
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.168381
ATP10A ATPase, class V, type 10A 0.167224
SIK2 salt-inducible kinase 2 0.166544
TNS1 tensin 1 0.166319
HNF4A hepatocyte nuclear factor 4, alpha 0.165874
A1CF APOBEC1 complementation factor 0.164786
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.163729
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.163523
CLOCK clock circadian regulator 0.161331
LAMA1 laminin, alpha 1 0.160948
SIRT2 sirtuin 2 0.160761
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 0.160761
ICAM1 intercellular adhesion molecule 1 0.160574
RAB18 RAB18, member RAS oncogene family 0.160574
PDGFC platelet derived growth factor C 0.160387
EIF4A2 eukaryotic translation initiation factor 4A2 0.160203
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.159838
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.159124
INCENP inner centromere protein antigens 135/155kDa 0.158951
NRD1 nardilysin (N-arginine dibasic convertase) 0.158097
PPARD peroxisome proliferator-activated receptor delta 0.157929
CHIT1 chitinase 1 (chitotriosidase) 0.157602