fatty acid α-oxidation Gene Set

Dataset HumanCyc Pathways
Category structural or functional annotations
Type pathway
Description A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway. (Gene Ontology, GO_0001561)
External Link http://humancyc.org/HUMAN/NEW-IMAGE?type=PATHWAY&object=PWY66-387
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Genes

5 proteins participating in the fatty acid α-oxidation pathway from the HumanCyc Pathways dataset.

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
HACL1 2-hydroxyacyl-CoA lyase 1
PHYH phytanoyl-CoA 2-hydroxylase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2