fasudil-436 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the fasudil-436 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ANAPC2 anaphase promoting complex subunit 2
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARNT aryl hydrocarbon receptor nuclear translocator
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASIC1 acid sensing (proton gated) ion channel 1
ATG13 autophagy related 13
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATP5SL ATP5S-like
AXIN1 axin 1
BAIAP3 BAI1-associated protein 3
C3ORF18 chromosome 3 open reading frame 18
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CC2D1A coiled-coil and C2 domain containing 1A
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CHN2 chimerin 2
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CLCN6 chloride channel, voltage-sensitive 6
CNR1 cannabinoid receptor 1 (brain)
COIL coilin
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DIO2 deiodinase, iodothyronine, type II
DMXL2 Dmx-like 2
EDA2R ectodysplasin A2 receptor
EFNB3 ephrin-B3
FAM49B family with sequence similarity 49, member B
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF1 fibroblast growth factor 1 (acidic)
FHL3 four and a half LIM domains 3
FXR2 fragile X mental retardation, autosomal homolog 2
GALR3 galanin receptor 3
HEATR6 HEAT repeat containing 6
HIST1H4J histone cluster 1, H4j
HMBOX1 homeobox containing 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPX hemopexin
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IL1RL1 interleukin 1 receptor-like 1
ITGA8 integrin, alpha 8
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KNOP1 lysine-rich nucleolar protein 1
LZTS1 leucine zipper, putative tumor suppressor 1
MAOA monoamine oxidase A
MTMR8 myotubularin related protein 8
MVK mevalonate kinase
NCS1 neuronal calcium sensor 1
NOL6 nucleolar protein 6 (RNA-associated)
NOL8 nucleolar protein 8
NOVA2 neuro-oncological ventral antigen 2
NUP160 nucleoporin 160kDa
ONECUT2 one cut homeobox 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PCBP2 poly(rC) binding protein 2
PHOX2B paired-like homeobox 2b
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKD2L1 polycystic kidney disease 2-like 1
PLCL2 phospholipase C-like 2
PLSCR3 phospholipid scramblase 3
POMT1 protein-O-mannosyltransferase 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKCA protein kinase C, alpha
PRR14 proline rich 14
PSD3 pleckstrin and Sec7 domain containing 3
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRN protein tyrosine phosphatase, receptor type, N
PUS3 pseudouridylate synthase 3
PVT1 Pvt1 oncogene (non-protein coding)
RITA1 RBPJ interacting and tubulin associated 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RUNX1 runt-related transcription factor 1
SAG S-antigen; retina and pineal gland (arrestin)
SC5D sterol-C5-desaturase
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPC surfactant protein C
SH2B2 SH2B adaptor protein 2
SHPK sedoheptulokinase
SIRPB1 signal-regulatory protein beta 1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC38A7 solute carrier family 38, member 7
SPG20 spastic paraplegia 20 (Troyer syndrome)
TBX10 T-box 10
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TEX41 testis expressed 41 (non-protein coding)
TM4SF5 transmembrane 4 L six family member 5
TMEM57 transmembrane protein 57
TNS1 tensin 1
TRAF4 TNF receptor-associated factor 4
TTLL4 tubulin tyrosine ligase-like family member 4
TTR transthyretin
USF2 upstream transcription factor 2, c-fos interacting
USP29 ubiquitin specific peptidase 29
USP46 ubiquitin specific peptidase 46
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABHD3 abhydrolase domain containing 3
ANKRD36B ankyrin repeat domain 36B
ATXN2 ataxin 2
BCL9 B-cell CLL/lymphoma 9
CA5BP1 carbonic anhydrase VB pseudogene 1
CA9 carbonic anhydrase IX
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC176 coiled-coil domain containing 176
CCDC71 coiled-coil domain containing 71
CD5 CD5 molecule
CD83 CD83 molecule
CLCN5 chloride channel, voltage-sensitive 5
CLTCL1 clathrin, heavy chain-like 1
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CSAD cysteine sulfinic acid decarboxylase
DAGLA diacylglycerol lipase, alpha
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DOK5 docking protein 5
DPEP1 dipeptidase 1 (renal)
EPX eosinophil peroxidase
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
FGF4 fibroblast growth factor 4
FKTN fukutin
GML glycosylphosphatidylinositol anchored molecule like
GPC3 glypican 3
GPR35 G protein-coupled receptor 35
GPR39 G protein-coupled receptor 39
GREB1L growth regulation by estrogen in breast cancer-like
GSR glutathione reductase
HOXC10 homeobox C10
IL10RA interleukin 10 receptor, alpha
IL36RN interleukin 36 receptor antagonist
JADE3 jade family PHD finger 3
KIFAP3 kinesin-associated protein 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KRCC1 lysine-rich coiled-coil 1
LSR lipolysis stimulated lipoprotein receptor
LUZP4 leucine zipper protein 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYRM2 LYR motif containing 2
MAGEA5 melanoma antigen family A5
MBIP MAP3K12 binding inhibitory protein 1
MED31 mediator complex subunit 31
MEGF6 multiple EGF-like-domains 6
METTL2B methyltransferase like 2B
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MPHOSPH8 M-phase phosphoprotein 8
MUC2 mucin 2, oligomeric mucus/gel-forming
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR3C2 nuclear receptor subfamily 3, group C, member 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PACS1 phosphofurin acidic cluster sorting protein 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G10 phospholipase A2, group X
PRDM11 PR domain containing 11
PYCRL pyrroline-5-carboxylate reductase-like
REC8 REC8 meiotic recombination protein
RFWD3 ring finger and WD repeat domain 3
RNF141 ring finger protein 141
RNF39 ring finger protein 39
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPP1 selenoprotein P, plasma, 1
SETD1B SET domain containing 1B
SLC17A4 solute carrier family 17, member 4
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SOX21 SRY (sex determining region Y)-box 21
STAB2 stabilin 2
STARD13 StAR-related lipid transfer (START) domain containing 13
TBX3 T-box 3
TCEAL1 transcription elongation factor A (SII)-like 1
TESK2 testis-specific kinase 2
TG thyroglobulin
THSD4 thrombospondin, type I, domain containing 4
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TLR5 toll-like receptor 5
TMEM140 transmembrane protein 140
TMEM209 transmembrane protein 209
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNS4 tensin 4
TRAPPC12 trafficking protein particle complex 12
TRIM58 tripartite motif containing 58
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTN titin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC93B1 unc-93 homolog B1 (C. elegans)
USP6 ubiquitin specific peptidase 6
VWA1 von Willebrand factor A domain containing 1
WDR4 WD repeat domain 4
WDR5B WD repeat domain 5B
ZNF358 zinc finger protein 358
ZNF510 zinc finger protein 510