fanconi anaemia nuclear complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. (Gene Ontology, GO_0043240)
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86 proteins co-occuring with the fanconi anaemia nuclear complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
FANCD2 Fanconi anemia, complementation group D2 3.02872
FANCA Fanconi anemia, complementation group A 2.71352
FANCC Fanconi anemia, complementation group C 2.44013
FANCI Fanconi anemia, complementation group I 2.29003
FANCM Fanconi anemia, complementation group M 2.18374
FANCF Fanconi anemia, complementation group F 2.17125
FANCE Fanconi anemia, complementation group E 2.0838
BRCA2 breast cancer 2, early onset 1.98053
FANCL Fanconi anemia, complementation group L 1.95162
C19ORF40 chromosome 19 open reading frame 40 1.77015
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.76561
PALB2 partner and localizer of BRCA2 1.61764
FANCG Fanconi anemia, complementation group G 1.53387
C17ORF70 chromosome 17 open reading frame 70 1.48079
BRCA1 breast cancer 1, early onset 1.35594
FAN1 FANCD2/FANCI-associated nuclease 1 1.34065
STRA13 stimulated by retinoic acid 13 1.22412
HELQ helicase, POLQ-like 1.20189
UBE2T ubiquitin-conjugating enzyme E2T 1.09696
RAD51 RAD51 recombinase 1.05035
FANCB Fanconi anemia, complementation group B 0.93596
ZNF169 zinc finger protein 169 0.935488
MRPL36 mitochondrial ribosomal protein L36 0.935488
APITD1 apoptosis-inducing, TAF9-like domain 1 0.930774
GGNBP2 gametogenetin binding protein 2 0.867666
ATM ATM serine/threonine kinase 0.826794
EXD2 exonuclease 3'-5' domain containing 2 0.811193
CHEK1 checkpoint kinase 1 0.787359
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 0.746381
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.73287
RBBP8 retinoblastoma binding protein 8 0.723026
ATRIP ATR interacting protein 0.715014
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.688576
RAD18 RAD18 E3 ubiquitin protein ligase 0.681591
PHF2 PHD finger protein 2 0.678108
PARK2 parkin RBR E3 ubiquitin protein ligase 0.641001
GGNBP1 gametogenetin binding protein 1 (pseudogene) 0.60655
USP1 ubiquitin specific peptidase 1 0.598117
TELO2 telomere maintenance 2 0.579669
ERCC4 excision repair cross-complementation group 4 0.538238
SLX4 SLX4 structure-specific endonuclease subunit 0.537827
RMI1 RecQ mediated genome instability 1 0.531258
PLRG1 pleiotropic regulator 1 0.499042
HBS1L HBS1-like translational GTPase 0.497015
RTEL1 regulator of telomere elongation helicase 1 0.49661
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 0.482467
TOPBP1 topoisomerase (DNA) II binding protein 1 0.47844
NBN nibrin 0.471609
BLM Bloom syndrome, RecQ helicase-like 0.424745
XPA xeroderma pigmentosum, complementation group A 0.423174
PRPF19 pre-mRNA processing factor 19 0.41886
NHEJ1 nonhomologous end-joining factor 1 0.41221
PCNA proliferating cell nuclear antigen 0.410649
UROS uroporphyrinogen III synthase 0.404804
RMI2 RecQ mediated genome instability 2 0.387365
GLRA1 glycine receptor, alpha 1 0.384665
OAZ3 ornithine decarboxylase antizyme 3 0.380429
RAD17 RAD17 homolog (S. pombe) 0.378507
APEH acylaminoacyl-peptide hydrolase 0.324576
HBG1 hemoglobin, gamma A 0.324201
GGN gametogenetin 0.32345
CHEK2 checkpoint kinase 2 0.304399
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.299569
CCNE2 cyclin E2 0.297713
RAD50 RAD50 homolog (S. cerevisiae) 0.295489
ATAD5 ATPase family, AAA domain containing 5 0.290308
UBE2H ubiquitin-conjugating enzyme E2H 0.289938
CDC25A cell division cycle 25A 0.284032
ATR ATR serine/threonine kinase 0.280716
DDN dendrin 0.275202
ERCC1 excision repair cross-complementation group 1 0.266774
BCAS2 breast carcinoma amplified sequence 2 0.26166
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.250026
SAA1 serum amyloid A1 0.236683
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.236683
TOP3A topoisomerase (DNA) III alpha 0.229176
BIK BCL2-interacting killer (apoptosis-inducing) 0.225622
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.224204
CUL1 cullin 1 0.211933
RAD51C RAD51 paralog C 0.196339
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.193719
CAND1 cullin-associated and neddylation-dissociated 1 0.185777
CDC5L cell division cycle 5-like 0.182422
SBDS Shwachman-Bodian-Diamond syndrome 0.161275
CCNE1 cyclin E1 0.160254
RECQL4 RecQ protein-like 4 0.158129