famprofazone-6029 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the famprofazone-6029 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMPD1 adenosine monophosphate deaminase 1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BCL6 B-cell CLL/lymphoma 6
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCDC28B coiled-coil domain containing 28B
CD200 CD200 molecule
CD6 CD6 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK18 cyclin-dependent kinase 18
CES3 carboxylesterase 3
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLEC4M C-type lectin domain family 4, member M
COL6A1 collagen, type VI, alpha 1
COL7A1 collagen, type VII, alpha 1
CPA4 carboxypeptidase A4
CRTC1 CREB regulated transcription coactivator 1
DGCR8 DGCR8 microprocessor complex subunit
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DPY19L1P1 DPY19L1 pseudogene 1
DUSP13 dual specificity phosphatase 13
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EMID1 EMI domain containing 1
EPHB2 EPH receptor B2
EPS8L3 EPS8-like 3
ETV7 ets variant 7
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FER1L4 fer-1-like family member 4, pseudogene (functional)
FHL3 four and a half LIM domains 3
FN1 fibronectin 1
FZD10 frizzled class receptor 10
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GPATCH4 G patch domain containing 4
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GVINP1 GTPase, very large interferon inducible pseudogene 1
GYPB glycophorin B (MNS blood group)
HES2 hes family bHLH transcription factor 2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IDUA iduronidase, alpha-L-
INHBE inhibin, beta E
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
LEFTY2 left-right determination factor 2
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LMF2 lipase maturation factor 2
LOC729164 hCG1732469
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MED25 mediator complex subunit 25
MFSD7 major facilitator superfamily domain containing 7
MYOZ1 myozenin 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR4A3 nuclear receptor subfamily 4, group A, member 3
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PDE4DIP phosphodiesterase 4D interacting protein
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNPLA3 patatin-like phospholipase domain containing 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PVR poliovirus receptor
RASA3 RAS p21 protein activator 3
RASL11B RAS-like, family 11, member B
RBM17 RNA binding motif protein 17
RGS12 regulator of G-protein signaling 12
RNASE4 ribonuclease, RNase A family, 4
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS4Y1 ribosomal protein S4, Y-linked 1
RUNDC3A RUN domain containing 3A
SCAMP1 secretory carrier membrane protein 1
SETBP1 SET binding protein 1
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SIRT5 sirtuin 5
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SNCAIP synuclein, alpha interacting protein
SOCS7 suppressor of cytokine signaling 7
SPP1 secreted phosphoprotein 1
STAC SH3 and cysteine rich domain
TACR2 tachykinin receptor 2
TAPBP TAP binding protein (tapasin)
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNS1 tensin 1
VIM vimentin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ADM adrenomedullin
ALPK1 alpha-kinase 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARL15 ADP-ribosylation factor-like 15
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BAGE B melanoma antigen
C1ORF159 chromosome 1 open reading frame 159
C5 complement component 5
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAPN5 calpain 5
CCDC132 coiled-coil domain containing 132
CD83 CD83 molecule
CDON cell adhesion associated, oncogene regulated
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTFR ciliary neurotrophic factor receptor
CRLF1 cytokine receptor-like factor 1
CSF1R colony stimulating factor 1 receptor
DGAT1 diacylglycerol O-acyltransferase 1
DNM3 dynamin 3
DSPP dentin sialophosphoprotein
DYSF dysferlin
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELSPBP1 epididymal sperm binding protein 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
FANCE Fanconi anemia, complementation group E
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FLT4 fms-related tyrosine kinase 4
FRS2 fibroblast growth factor receptor substrate 2
GAN gigaxonin
GATA4 GATA binding protein 4
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H3B histone cluster 1, H3b
HPN hepsin
IL12RB1 interleukin 12 receptor, beta 1
INF2 inverted formin, FH2 and WH2 domain containing
INO80D INO80 complex subunit D
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF13B kinesin family member 13B
KIFC1 kinesin family member C1
KREMEN2 kringle containing transmembrane protein 2
KRI1 KRI1 homolog (S. cerevisiae)
LHX1 LIM homeobox 1
LMBR1L limb development membrane protein 1-like
LMX1B LIM homeobox transcription factor 1, beta
LRP5L low density lipoprotein receptor-related protein 5-like
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MRPL2 mitochondrial ribosomal protein L2
MRPL44 mitochondrial ribosomal protein L44
NABP2 nucleic acid binding protein 2
NDOR1 NADPH dependent diflavin oxidoreductase 1
ONECUT2 one cut homeobox 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PCDHA5 protocadherin alpha 5
PDGFRL platelet-derived growth factor receptor-like
PHOX2A paired-like homeobox 2a
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMCH pro-melanin-concentrating hormone
R3HCC1L R3H domain and coiled-coil containing 1-like
RASAL1 RAS protein activator like 1 (GAP1 like)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCAN3 RCAN family member 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A2 solute carrier family 17, member 2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
STRA6 stimulated by retinoic acid 6
TBL3 transducin (beta)-like 3
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TH tyrosine hydroxylase
TMC5 transmembrane channel-like 5
TRDMT1 tRNA aspartic acid methyltransferase 1
TTLL1 tubulin tyrosine ligase-like family member 1
USP27X ubiquitin specific peptidase 27, X-linked
VAX2 ventral anterior homeobox 2
VIPR1 vasoactive intestinal peptide receptor 1
WDR25 WD repeat domain 25
WDR33 WD repeat domain 33
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB48 zinc finger and BTB domain containing 48
ZFHX4 zinc finger homeobox 4
ZNF37BP zinc finger protein 37B, pseudogene
ZNF428 zinc finger protein 428