famotidine-2029 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the famotidine-2029 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADAR adenosine deaminase, RNA-specific
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AMBRA1 autophagy/beclin-1 regulator 1
ANKRD55 ankyrin repeat domain 55
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
AQP8 aquaporin 8
ARRB2 arrestin, beta 2
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
BAX BCL2-associated X protein
BICD2 bicaudal D homolog 2 (Drosophila)
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C22ORF24 chromosome 22 open reading frame 24
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
C8ORF44 chromosome 8 open reading frame 44
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CEP68 centrosomal protein 68kDa
CETN1 centrin, EF-hand protein, 1
CHKA choline kinase alpha
CIDEC cell death-inducing DFFA-like effector c
CLDN15 claudin 15
COL4A2 collagen, type IV, alpha 2
COMT catechol-O-methyltransferase
DCTN4 dynactin 4 (p62)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
ELMO2 engulfment and cell motility 2
ELOVL6 ELOVL fatty acid elongase 6
EPX eosinophil peroxidase
FBXW11 F-box and WD repeat domain containing 11
FKBP9 FK506 binding protein 9, 63 kDa
FNTB farnesyltransferase, CAAX box, beta
GABPB1 GA binding protein transcription factor, beta subunit 1
GCAT glycine C-acetyltransferase
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS glutaminase
GMDS GDP-mannose 4,6-dehydratase
HIST1H4J histone cluster 1, H4j
HP1BP3 heterochromatin protein 1, binding protein 3
HR hair growth associated
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
JRK Jrk homolog (mouse)
KIFC1 kinesin family member C1
LDB1 LIM domain binding 1
LPP LIM domain containing preferred translocation partner in lipoma
LRRK1 leucine-rich repeat kinase 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MED27 mediator complex subunit 27
MYF6 myogenic factor 6 (herculin)
N4BP1 NEDD4 binding protein 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUP160 nucleoporin 160kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCIF1 PDX1 C-terminal inhibiting factor 1
PGC progastricsin (pepsinogen C)
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PILRB paired immunoglobin-like type 2 receptor beta
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PITPNA phosphatidylinositol transfer protein, alpha
PLIN2 perilipin 2
POFUT1 protein O-fucosyltransferase 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRDM14 PR domain containing 14
PSG9 pregnancy specific beta-1-glycoprotein 9
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBM48 RNA binding motif protein 48
REC8 REC8 meiotic recombination protein
RECQL4 RecQ protein-like 4
RHOT2 ras homolog family member T2
SCCPDH saccharopine dehydrogenase (putative)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SETD4 SET domain containing 4
SIGLEC5 sialic acid binding Ig-like lectin 5
SIRT3 sirtuin 3
SLC22A14 solute carrier family 22, member 14
SLC31A1 solute carrier family 31 (copper transporter), member 1
SPPL2B signal peptide peptidase like 2B
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
TCF3 transcription factor 3
TERT telomerase reverse transcriptase
TEX261 testis expressed 261
THTPA thiamine triphosphatase
TMED2 transmembrane emp24 domain trafficking protein 2
TPM3 tropomyosin 3
TRABD TraB domain containing
TRAF3IP3 TRAF3 interacting protein 3
TTLL4 tubulin tyrosine ligase-like family member 4
WDR48 WD repeat domain 48
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZNF335 zinc finger protein 335

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AACS acetoacetyl-CoA synthetase
ACSL5 acyl-CoA synthetase long-chain family member 5
AES amino-terminal enhancer of split
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
APH1B APH1B gamma secretase subunit
ARG1 arginase 1
ASCC1 activating signal cointegrator 1 complex subunit 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL10 B-cell CLL/lymphoma 10
BCL7C B-cell CLL/lymphoma 7C
CARD9 caspase recruitment domain family, member 9
CCDC53 coiled-coil domain containing 53
CD248 CD248 molecule, endosialin
CD2AP CD2-associated protein
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLP1 cleavage and polyadenylation factor I subunit 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COMMD10 COMM domain containing 10
CSF1R colony stimulating factor 1 receptor
CTAGE9 CTAGE family, member 9
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYCS cytochrome c, somatic
DEAF1 DEAF1 transcription factor
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DPF2 D4, zinc and double PHD fingers family 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP5 dual specificity phosphatase 5
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EDAR ectodysplasin A receptor
EHD4 EH-domain containing 4
FAHD2A fumarylacetoacetate hydrolase domain containing 2A
FAM111A family with sequence similarity 111, member A
FAM118A family with sequence similarity 118, member A
FMO4 flavin containing monooxygenase 4
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GPALPP1 GPALPP motifs containing 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HACD2 3-hydroxyacyl-CoA dehydratase 2
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPKC inositol-trisphosphate 3-kinase C
LINC00339 long intergenic non-protein coding RNA 339
LOC642236 FSHD region gene 1 pseudogene
LONRF3 LON peptidase N-terminal domain and ring finger 3
MAGT1 magnesium transporter 1
MRPL19 mitochondrial ribosomal protein L19
MT1HL1 metallothionein 1H-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PABPC3 poly(A) binding protein, cytoplasmic 3
PCSK7 proprotein convertase subtilisin/kexin type 7
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PKN1 protein kinase N1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PTER phosphotriesterase related
RBM4B RNA binding motif protein 4B
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPUSD2 RNA pseudouridylate synthase domain containing 2
RSF1 remodeling and spacing factor 1
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2B3 SH2B adaptor protein 3
SNHG3 small nucleolar RNA host gene 3
SPC25 SPC25, NDC80 kinetochore complex component
SPON2 spondin 2, extracellular matrix protein
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPX spexin hormone
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TAC3 tachykinin 3
TBC1D31 TBC1 domain family, member 31
TCTN2 tectonic family member 2
TESK2 testis-specific kinase 2
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TMEM115 transmembrane protein 115
TMEM14A transmembrane protein 14A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOB1 transducer of ERBB2, 1
TTF2 transcription termination factor, RNA polymerase II
TXNL4B thioredoxin-like 4B
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UBP1 upstream binding protein 1 (LBP-1a)
UBQLN4 ubiquilin 4
UFM1 ubiquitin-fold modifier 1
USB1 U6 snRNA biogenesis 1
ZC3H12A zinc finger CCCH-type containing 12A
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF268 zinc finger protein 268
ZNF33B zinc finger protein 33B
ZNF432 zinc finger protein 432