familial hyperlipidemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Similar Terms
Downloads & Tools

Genes

240 genes co-occuring with the disease familial hyperlipidemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
USF1 upstream transcription factor 1 3.10386
APOB apolipoprotein B 2.65758
LPL lipoprotein lipase 2.42324
LDLR low density lipoprotein receptor 2.30863
COG2 component of oligomeric golgi complex 2 1.93421
PCSK9 proprotein convertase subtilisin/kexin type 9 1.87561
APOA1 apolipoprotein A-I 1.76954
INS insulin 1.71681
APOE apolipoprotein E 1.67412
APOC3 apolipoprotein C-III 1.61039
LPA lipoprotein, Lp(a) 1.51237
APOC2 apolipoprotein C-II 1.49921
APOA2 apolipoprotein A-II 1.41095
APOA5 apolipoprotein A-V 1.39127
CETP cholesteryl ester transfer protein, plasma 1.26865
LCAT lecithin-cholesterol acyltransferase 1.26081
LIPC lipase, hepatic 1.26081
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.25863
MTTP microsomal triglyceride transfer protein 1.19748
PPARA peroxisome proliferator-activated receptor alpha 1.13628
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.05555
ALB albumin 1.02861
LIPE lipase, hormone-sensitive 0.978848
PPARG peroxisome proliferator-activated receptor gamma 0.977165
OSBPL2 oxysterol binding protein-like 2 0.965825
ACE angiotensin I converting enzyme 0.955779
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 0.955361
PNLIP pancreatic lipase 0.951187
LEP leptin 0.922974
SLC25A40 solute carrier family 25, member 40 0.90732
PLTP phospholipid transfer protein 0.879424
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.879014
TXNIP thioredoxin interacting protein 0.877786
CHD1L chromodomain helicase DNA binding protein 1-like 0.855268
CRP C-reactive protein, pentraxin-related 0.836017
DLL1 delta-like 1 (Drosophila) 0.830279
C1ORF159 chromosome 1 open reading frame 159 0.800744
APOC1 apolipoprotein C-I 0.777795
SREBF2 sterol regulatory element binding transcription factor 2 0.767576
RXRG retinoid X receptor, gamma 0.758193
LYPLA2 lysophospholipase II 0.75412
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.739894
MYDGF myeloid-derived growth factor 0.739488
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.730976
DYNLL1 dynein, light chain, LC8-type 1 0.727738
GCG glucagon 0.718443
OSBPL10 oxysterol binding protein-like 10 0.714811
COPS8 COP9 signalosome subunit 8 0.713198
NPC1L1 NPC1-like 1 0.692296
VWF von Willebrand factor 0.692296
ELOVL1 ELOVL fatty acid elongase 1 0.688291
HRAS Harvey rat sarcoma viral oncogene homolog 0.676308
SREBF1 sterol regulatory element binding transcription factor 1 0.669538
G6PC glucose-6-phosphatase, catalytic subunit 0.657234
SCARB1 scavenger receptor class B, member 1 0.654858
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.651298
CERS4 ceramide synthase 4 0.645375
PSTK phosphoseryl-tRNA kinase 0.640645
UXS1 UDP-glucuronate decarboxylase 1 0.638282
LDLRAP1 low density lipoprotein receptor adaptor protein 1 0.625319
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.621008
BUD13 BUD13 homolog (S. cerevisiae) 0.615529
CABIN1 calcineurin binding protein 1 0.605372
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 0.593285
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.587444
TGM4 transglutaminase 4 0.584719
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.581606
USF2 upstream transcription factor 2, c-fos interacting 0.579661
COG1 component of oligomeric golgi complex 1 0.576161
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.566831
C3 complement component 3 0.565277
OSBPL9 oxysterol binding protein-like 9 0.564889
SP6 Sp6 transcription factor 0.55518
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.541992
VLDLR very low density lipoprotein receptor 0.529222
PLG plasminogen 0.528063
F3 coagulation factor III (thromboplastin, tissue factor) 0.514186
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.513802
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.513033
F2 coagulation factor II (thrombin) 0.510728
FADS3 fatty acid desaturase 3 0.509576
F11R F11 receptor 0.509576
C5AR2 complement component 5a receptor 2 0.508041
VCAM1 vascular cell adhesion molecule 1 0.507657
SOD2 superoxide dismutase 2, mitochondrial 0.493885
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.484744
LMF1 lipase maturation factor 1 0.482844
GPX1 glutathione peroxidase 1 0.478668
SELE selectin E 0.471089
FASN fatty acid synthase 0.458619
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.457864
GPX4 glutathione peroxidase 4 0.457864
APOA4 apolipoprotein A-IV 0.453716
ACADSB acyl-CoA dehydrogenase, short/branched chain 0.439786
APOD apolipoprotein D 0.436778
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.436778
APOC4 apolipoprotein C-IV 0.427765
GPX5 glutathione peroxidase 5 0.422515
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.413901
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.410161
GSPT2 G1 to S phase transition 2 0.408666
FABP4 fatty acid binding protein 4, adipocyte 0.406425
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.404931
PON1 paraoxonase 1 0.403064
SCARB2 scavenger receptor class B, member 2 0.399334
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) 0.391513
KDM1B lysine (K)-specific demethylase 1B 0.388909
PLAT plasminogen activator, tissue 0.387794
CD36 CD36 molecule (thrombospondin receptor) 0.383708
ZPR1 ZPR1 zinc finger 0.383337
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.382594
EDN1 endothelin 1 0.37555
INTS8 integrator complex subunit 8 0.374809
PPT1 palmitoyl-protein thioesterase 1 0.36741
ACAT1 acetyl-CoA acetyltransferase 1 0.360764
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 0.357077
MRVI1 murine retrovirus integration site 1 homolog 0.340906
HNF4A hepatocyte nuclear factor 4, alpha 0.339806
TGIF1 TGFB-induced factor homeobox 1 0.338707
GGT1 gamma-glutamyltransferase 1 0.325552
MGAM maltase-glucoamylase 0.318635
CREB3L3 cAMP responsive element binding protein 3-like 3 0.316819
PROS1 protein S (alpha) 0.315003
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.31464
TGM6 transglutaminase 6 0.312827
ALPPL2 alkaline phosphatase, placental-like 2 0.312464
ALPP alkaline phosphatase, placental 0.312102
ALPL alkaline phosphatase, liver/bone/kidney 0.311377
ZNF197 zinc finger protein 197 0.309928
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.309928
BAAT bile acid CoA:amino acid N-acyltransferase 0.309566
STARD8 StAR-related lipid transfer (START) domain containing 8 0.308842
SLC35G5 solute carrier family 35, member G5 0.30631
CCL2 chemokine (C-C motif) ligand 2 0.304864
CSTB cystatin B (stefin B) 0.304864
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.298371
ADRB3 adrenoceptor beta 3 0.294772
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.291898
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64) 0.285802
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 0.28151
ACLY ATP citrate lyase 0.28151
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 0.279724
TF transferrin 0.277584
FABP2 fatty acid binding protein 2, intestinal 0.275445
ICAM1 intercellular adhesion molecule 1 0.271174
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.269043
CRABP2 cellular retinoic acid binding protein 2 0.267622
F12 coagulation factor XII (Hageman factor) 0.267267
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 0.267267
GABPB1 GA binding protein transcription factor, beta subunit 1 0.261952
TPGS2 tubulin polyglutamylase complex subunit 2 0.25983
ATF6 activating transcription factor 6 0.258417
CPT1A carnitine palmitoyltransferase 1A (liver) 0.255241
PCSK7 proprotein convertase subtilisin/kexin type 7 0.252422
MMP9 matrix metallopeptidase 9 0.251015
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.250311
NOS3 nitric oxide synthase 3 (endothelial cell) 0.24996
FFAR1 free fatty acid receptor 1 0.245396
CD4 CD4 molecule 0.243995
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.241196
OSBP oxysterol binding protein 0.240847
SDC2 syndecan 2 0.23492
F5 coagulation factor V (proaccelerin, labile factor) 0.232142
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.229716
ECI1 enoyl-CoA delta isomerase 1 0.227988
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.221108
FOXC2 forkhead box C2 0.216332
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.215653
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.214975
TFPI2 tissue factor pathway inhibitor 2 0.214297
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 0.213621
PKM pyruvate kinase, muscle 0.212608
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 0.210925
CD96 CD96 molecule 0.210253
GCAT glycine C-acetyltransferase 0.206248
IGF1 insulin-like growth factor 1 (somatomedin C) 0.190786
LINC00207 long intergenic non-protein coding RNA 207 0.18651
LEPR leptin receptor 0.18651
PNPO pyridoxamine 5'-phosphate oxidase 0.18621
PNPLA2 patatin-like phospholipase domain containing 2 0.183541
FBL fibrillarin 0.182957
PYGB phosphorylase, glycogen; brain 0.181222
TNF tumor necrosis factor 0.180652
PYGL phosphorylase, glycogen, liver 0.178682
GNPDA1 glucosamine-6-phosphate deaminase 1 0.178126
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.177029
MLXIPL MLX interacting protein-like 0.177029
IRS1 insulin receptor substrate 1 0.176757
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 0.176485
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.174354
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.171286
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.167682
PKLR pyruvate kinase, liver and RBC 0.167452
CAT catalase 0.166544
NOX4 NADPH oxidase 4 0.163938
BCHE butyrylcholinesterase 0.162908
IL6 interleukin 6 0.162908
ADD1 adducin 1 (alpha) 0.162707
LIN7A lin-7 homolog A (C. elegans) 0.162306
PYGM phosphorylase, glycogen, muscle 0.162109
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.161331
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.160948
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.160574
VSNL1 visinin-like 1 0.159302
PON2 paraoxonase 2 0.158434
MNDA myeloid cell nuclear differentiation antigen 0.158266
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.142295
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.138252
AMT aminomethyltransferase 0.137112
SACS sacsin molecular chaperone 0.131068
INSIG1 insulin induced gene 1 0.130061
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.12927
C1QBP complement component 1, q subcomponent binding protein 0.128069
NPC1 Niemann-Pick disease, type C1 0.126228
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.125893
CTRL chymotrypsin-like 0.125135
HRG histidine-rich glycoprotein 0.124275
ANOS1 anosmin 1 0.123642
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.122328
SLC22A18 solute carrier family 22, member 18 0.122328
TRIB1 tribbles pseudokinase 1 0.120151
FGB fibrinogen beta chain 0.119274
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.118478
ANGPTL3 angiopoietin-like 3 0.118418
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.118206
INSC inscuteable homolog (Drosophila) 0.117341
PABPN1 poly(A) binding protein, nuclear 1 0.117122
IL1R2 interleukin 1 receptor, type II 0.115104
PLD2 phospholipase D2 0.114587
TXN thioredoxin 0.113187
PCDH15 protocadherin-related 15 0.112104
HBD hemoglobin, delta 0.111526
SCN2A sodium channel, voltage gated, type II alpha subunit 0.110742
HEXA hexosaminidase A (alpha polypeptide) 0.107676
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.107633
LST1 leukocyte specific transcript 1 0.106581
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.106403
CANX calnexin 0.104301
BACE2 beta-site APP-cleaving enzyme 2 0.102344
ERN1 endoplasmic reticulum to nucleus signaling 1 0.101999