familial atrial fibrillation Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes. (Human Disease Ontology, DOID_0050650)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:0050650
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Genes

96 genes associated with the disease familial atrial fibrillation in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.05547
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.90321
ZFHX3 zinc finger homeobox 3 1.85801
SYNE2 spectrin repeat containing, nuclear envelope 2 1.70502
CAV1 caveolin 1, caveolae protein, 22kDa 1.6622
C9ORF3 chromosome 9 open reading frame 3 1.60174
NKX2-5 NK2 homeobox 5 1.35343
WNT8A wingless-type MMTV integration site family, member 8A 1.26953
TBX5 T-box 5 1.25348
CES1 carboxylesterase 1 1.24194
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.23034
ARHGAP24 Rho GTPase activating protein 24 1.14463
SCN10A sodium channel, voltage gated, type X alpha subunit 1.11485
OSBP2 oxysterol binding protein 2 1.09769
GCH1 GTP cyclohydrolase 1 1.089
LRRC63 leucine rich repeat containing 63 1.04846
CNTN5 contactin 5 0.971169
PITX2 paired-like homeodomain 2 0.937304
HPX hemopexin 0.917442
NRG1 neuregulin 1 0.881544
IL12B interleukin 12B 0.88034
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 0.824776
ELANE elastase, neutrophil expressed 0.78442
PRKCH protein kinase C, eta 0.782562
APOA2 apolipoprotein A-II 0.779539
DRD2 dopamine receptor D2 0.778355
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.754216
TUBA8 tubulin, alpha 8 0.668836
CHKB choline kinase beta 0.668836
BTK Bruton agammaglobulinemia tyrosine kinase 0.650844
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.650844
MAPK1 mitogen-activated protein kinase 1 0.644215
NPPA natriuretic peptide A 0.611686
GJA5 gap junction protein, alpha 5, 40kDa 0.608439
FGG fibrinogen gamma chain 0.608439
TRAF1 TNF receptor-associated factor 1 0.596808
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.594024
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.594024
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.594024
IL1RAP interleukin 1 receptor accessory protein 0.591358
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.586345
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.586345
NLRP12 NLR family, pyrin domain containing 12 0.581707
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.57934
RYR2 ryanodine receptor 2 (cardiac) 0.57934
BCL2 B-cell CLL/lymphoma 2 0.577041
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.574821
COPS5 COP9 signalosome subunit 5 0.572673
TGFBR3 transforming growth factor, beta receptor III 0.572673
KCTD10 potassium channel tetramerization domain containing 10 0.570595
STARD3NL STARD3 N-terminal like 0.568581
PCSK6 proprotein convertase subtilisin/kexin type 6 0.568581
ACER3 alkaline ceramidase 3 0.564734
ADGRV1 adhesion G protein-coupled receptor V1 0.564734
RNF157 ring finger protein 157 0.562845
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.562845
CLCN6 chloride channel, voltage-sensitive 6 0.559045
MYOCD myocardin 0.552035
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.550393
IL6R interleukin 6 receptor 0.550393
PMVK phosphomevalonate kinase 0.54879
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 0.547225
LIPA lipase A, lysosomal acid, cholesterol esterase 0.547225
ADRB3 adrenoceptor beta 3 0.547225
UPB1 ureidopropionase, beta 0.547225
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.545697
GHSR growth hormone secretagogue receptor 0.544152
CDKN2B-AS1 CDKN2B antisense RNA 1 0.544152
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.539566
PLXNA4 plexin A4 0.538104
GAS7 growth arrest-specific 7 0.538104
CPA6 carboxypeptidase A6 0.532547
ACSM1 acyl-CoA synthetase medium-chain family member 1 0.531226
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.531226
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.52866
IGSF21 immunoglobin superfamily, member 21 0.524983
APOB apolipoprotein B 0.521489
PCSK5 proprotein convertase subtilisin/kexin type 5 0.520364
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.520364
LPAR1 lysophosphatidic acid receptor 1 0.520364
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.520364
RUNX1 runt-related transcription factor 1 0.511021
MSH3 mutS homolog 3 0.510061
CABIN1 calcineurin binding protein 1 0.510061
TRIM55 tripartite motif containing 55 0.509115
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.508182
DEPTOR DEP domain containing MTOR-interacting protein 0.507322
COL4A1 collagen, type IV, alpha 1 0.506603
NUCB2 nucleobindin 2 0.506603
PDE8A phosphodiesterase 8A 0.503149
FOXO1 forkhead box O1 0.502485
TTN titin 0.502485
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.500542
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.49991
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.499285
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.498668