familial adenomatous polyposis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer. (Human Disease Ontology, DOID_0050424)
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Genes

176 genes co-occuring with the disease familial adenomatous polyposis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
APC adenomatous polyposis coli 2.80469
MUTYH mutY homolog 2.36595
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.83591
MSH2 mutS homolog 2 1.74778
MLH1 mutL homolog 1 1.71317
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.52116
MSH6 mutS homolog 6 1.44913
KRAS Kirsten rat sarcoma viral oncogene homolog 1.41446
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.37469
REEP5 receptor accessory protein 5 1.33327
HRAS Harvey rat sarcoma viral oncogene homolog 1.33196
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.27824
SRP19 signal recognition particle 19kDa 1.27388
TP53 tumor protein p53 1.27344
AXIN1 axin 1 1.24558
AXIN2 axin 2 1.20223
HNF4A hepatocyte nuclear factor 4, alpha 1.16478
FKBP1A FK506 binding protein 1A, 12kDa 1.12403
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 1.09545
BMPR1A bone morphogenetic protein receptor, type IA 1.06606
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.00288
CCND1 cyclin D1 1.00077
PALD1 phosphatase domain containing, paladin 1 0.977165
SMAD4 SMAD family member 4 0.97002
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.939119
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.905675
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.875329
PTEN phosphatase and tensin homolog 0.849945
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.811001
ODC1 ornithine decarboxylase 1 0.806898
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.785984
LYPD1 LY6/PLAUR domain containing 1 0.779841
BRCA1 breast cancer 1, early onset 0.770844
ANAPC10 anaphase promoting complex subunit 10 0.741923
MUC3A mucin 3A, cell surface associated 0.72612
BRCA2 breast cancer 2, early onset 0.718846
KRT24 keratin 24, type I 0.711183
CA7 carbonic anhydrase VII 0.706754
DSCC1 DNA replication and sister chromatid cohesion 1 0.683892
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.678302
RET ret proto-oncogene 0.674315
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 0.667947
RPL31 ribosomal protein L31 0.666755
GSK3B glycogen synthase kinase 3 beta 0.65565
BAX BCL2-associated X protein 0.646953
RSU1 Ras suppressor protein 1 0.635135
SPATA13 spermatogenesis associated 13 0.631205
NF1 neurofibromin 1 0.605762
SNRPE small nuclear ribonucleoprotein polypeptide E 0.585108
DCC DCC netrin 1 receptor 0.555956
ANAPC5 anaphase promoting complex subunit 5 0.554015
PLA2G1B phospholipase A2, group IB (pancreas) 0.553239
MRPL12 mitochondrial ribosomal protein L12 0.547807
PCNA proliferating cell nuclear antigen 0.520346
PLCG1 phospholipase C, gamma 1 0.512648
DLG1 discs, large homolog 1 (Drosophila) 0.512264
OGG1 8-oxoguanine DNA glycosylase 0.505356
ETNK1 ethanolamine kinase 1 0.483604
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.474877
FMO3 flavin containing monooxygenase 3 0.474119
APC2 adenomatosis polyposis coli 2 0.472604
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.468063
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.449194
MCC mutated in colorectal cancers 0.448817
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.439034
MEN1 multiple endocrine neoplasia I 0.424765
BOK BCL2-related ovarian killer 0.413901
ZNF148 zinc finger protein 148 0.408666
PARP1 poly (ADP-ribose) polymerase 1 0.404557
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.401945
GAS2 growth arrest-specific 2 0.401945
STK11 serine/threonine kinase 11 0.401199
SKP1 S-phase kinase-associated protein 1 0.400826
FBLIM1 filamin binding LIM protein 1 0.397471
MUC2 mucin 2, oligomeric mucus/gel-forming 0.393001
GSTA1 glutathione S-transferase alpha 1 0.387051
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.382223
CEMIP cell migration inducing protein, hyaluronan binding 0.381852
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.378143
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 0.359657
GMDS GDP-mannose 4,6-dehydratase 0.356341
SFRP1 secreted frizzled-related protein 1 0.352291
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.348981
NF2 neurofibromin 2 (merlin) 0.346777
FBXO44 F-box protein 44 0.346042
MUT methylmalonyl CoA mutase 0.344941
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.344207
OVGP1 oviductal glycoprotein 1, 120kDa 0.343473
MSH3 mutS homolog 3 0.331391
CUL4B cullin 4B 0.32373
PRAMEF6 PRAME family member 6 0.32009
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.319726
EGFR epidermal growth factor receptor 0.316456
RNASEH2A ribonuclease H2, subunit A 0.315366
HIPK2 homeodomain interacting protein kinase 2 0.312464
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1 0.311739
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.305587
SHKBP1 SH3KBP1 binding protein 1 0.305226
RB1 retinoblastoma 1 0.304142
TG thyroglobulin 0.30342
CDKN2A cyclin-dependent kinase inhibitor 2A 0.302337
WIF1 WNT inhibitory factor 1 0.298011
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.294772
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.284371
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.284013
SRRM2 serine/arginine repetitive matrix 2 0.280796
DIABLO diablo, IAP-binding mitochondrial protein 0.279724
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.275801
MMP7 matrix metallopeptidase 7 0.275445
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.274021
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.266203
IL10RB interleukin 10 receptor, beta 0.264431
GLUL glutamate-ammonia ligase 0.260538
PLA2G10 phospholipase A2, group X 0.257358
HPGDS hematopoietic prostaglandin D synthase 0.255241
CTBP1 C-terminal binding protein 1 0.253479
UGT2B11 UDP glucuronosyltransferase 2 family, polypeptide B11 0.25207
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 0.247852
PTCH1 patched 1 0.246448
HNF1A HNF1 homeobox A 0.246448
PPARG peroxisome proliferator-activated receptor gamma 0.241895
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.240847
ZNF410 zinc finger protein 410 0.240497
FAP fibroblast activation protein, alpha 0.238752
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.238054
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 0.237706
DEFA5 defensin, alpha 5, Paneth cell-specific 0.237706
COL5A2 collagen, type V, alpha 2 0.23666
DPEP1 dipeptidase 1 (renal) 0.235616
ELAVL1 ELAV like RNA binding protein 1 0.232836
SGK1 serum/glucocorticoid regulated kinase 1 0.232142
WNT1 wingless-type MMTV integration site family, member 1 0.231448
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.230755
IGF2R insulin-like growth factor 2 receptor 0.230409
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.228679
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.225917
IHH indian hedgehog 0.21974
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 0.213959
SAMD11 sterile alpha motif domain containing 11 0.212271
KIF3A kinesin family member 3A 0.210253
GUK1 guanylate kinase 1 0.209248
ORM1 orosomucoid 1 0.208245
PPARD peroxisome proliferator-activated receptor delta 0.207912
FLCN folliculin 0.203933
SNED1 sushi, nidogen and EGF-like domains 1 0.203933
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.202618
PRPF4B pre-mRNA processing factor 4B 0.201962
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.199681
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 0.19742
DPP7 dipeptidyl-peptidase 7 0.197099
CA1 carbonic anhydrase I 0.196459
OCM2 oncomodulin 2 0.196459
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 0.195501
TLK1 tousled-like kinase 1 0.195501
IGF2 insulin-like growth factor 2 0.191097
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.188632
OCM oncomodulin 0.181798
ILK integrin-linked kinase 0.181222
PALLD palladin, cytoskeletal associated protein 0.17952
GAST gastrin 0.176757
CALCA calcitonin-related polypeptide alpha 0.176215
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.175411
GSTM1 glutathione S-transferase mu 1 0.172544
GSTA3 glutathione S-transferase alpha 3 0.171785
GSTA2 glutathione S-transferase alpha 2 0.170789
GSTA4 glutathione S-transferase alpha 4 0.170054
STK4 serine/threonine kinase 4 0.169812
FZD7 frizzled class receptor 7 0.168148
CRTC1 CREB regulated transcription coactivator 1 0.165655
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.162306
MBD4 methyl-CpG binding domain protein 4 0.162306
BCAR1 breast cancer anti-estrogen resistance 1 0.161912
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.159302
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.158951
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.158778
JAK3 Janus kinase 3 0.158434